Endpoint·Computed · in silico·Physicochemical

Instability index

instability_index · Sequence-derived

(10/L)·Σ DIWV(dipeptide). >40 suggests a sequence predicted unstable in vitro. Dipeptide weight table per Guruprasad 1990; exact match vs BioPython. Protein-derived — interpret cautiously for very short peptides.

Computed value — a deterministic descriptor validated against independent reference implementations; not an experimental measurement, and it carries no evidence support-class. Computed from the standard parent-residue sequence (a protein-origin metric, defined at any length). Not available for modified or non-standard sequences.

Peptides
18,184
Min
-79.55

Method & validation

Computation method: atlas-seq-descriptors v1
Literature: Guruprasad K, et al. Protein Eng. 1990;4(2):155-61.
Layer: Computed (in silico)
Applies to: Peptide backbone (sequence)

Representative peptides

Peptides with the highest values for this descriptor (of 18,184 computed). Each links to its peptide page.

JSON TSV

Peptide	Sequence	Value
pepcan:5e2b680ea86b3f24	RRRRRRRRRRRRRRRRRR	550.42
pepcan:65cd7a5861fc044c	rrrrrrrrrrrrrrrrrr	550.42
pepcan:3f154867c92a3b62	RRRRRRRRRRRR	534.23
pepcan:84f48e6dcf255228	RRRRRRRRRRR	529.82
pepcan:0e5a7b30b4e3e504	rrrrrrrrr	518.04
pepcan:6592d8f375dde01d	RRRRRRRRR	518.04

Instability index

See also · Sequence-derived computed endpoints