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Peptide·helm backed

ATLPC0000464

ATLPC0000464

['L', 'Me_dAbu', 'meL', 'L', 'dP', 'meY']

Compare in workbenchDownload releaseAPI JSON
On this page
  • 01 Sequence & molecular identity
  • 02 Physicochemical profile
  • 03 Distribution / Barrier
  • 04 Evidence landscape
  • 05 Product context
  • 06 Identity & reference map
  • 07 Data access & reproducibility
Coveragecounts only · not riskATLPC0000464
  • Measurements
    2
  • Endpoints
    1
  • Domains
    1/5
  • Products
    —
  • No matrix stability evidence
  • No clearance evidence
  • No immunogenicity context
  • No sequence liability cues
Jump to domain

Open the matching evidence section below

All evidence index · 2
Exposure / Absorption
No evidence
Distribution / Barrier
2 measurements
Metabolic & Proteolytic Stability
No evidence
Excretion / Persistence
No evidence
Toxicity / Safety
No evidence
01

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

·
Identity summarySpecific molecular form represented
Identity status
Specific molecular form represented
Residues
Not reported
Peptidoform features
0
Documented molecular forms
1
Representations
3
Documented molecular forms1 form linked to this peptide identity
FormTopologyModificationsConnectionsRepresentationsMeasurements
ATLPF0000511—4112
Residue view
Residue display

No parent-residue sequence can be rendered from the available representation.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

·
Chemical representationSMILES available
2D structure·RDKit.js
rendering molecule…
Canonical SMILES
CC[C@@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@@H]2C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N1C
Representation class

How the current release can interpret this identity chemically.

helm backed
Parent-residue sequence

Residue string used for positional interpretation when available.

['L', 'Me_dAbu', 'meL', 'L', 'dP', 'meY']
HELM

Polymer notation for modified peptide representation when available.

PEPTIDE2327{L.[Me_dAbu].[meL].L.[dP].[meY]}$PEPTIDE2327,PEPTIDE2327,1:R1-6:R2$$$
SMILES

Chemical graph string used for atom-level 2D depiction when available.

CC[C@@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@@H]2C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N1C
3D structure referencesnone attached
3D structure not available

A 3D structure isn't available for this peptide in the current release. Chemistry and topology fields remain available when represented by sequence, HELM, or SMILES.

Covalent topology & modificationsnone
Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

02

Physicochemical profile

6 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

Physicochemical descriptors unavailable

These descriptors require a standard parent-residue sequence. The module remains visible so modified or unresolved identities are not forced into unreliable computed values.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Structure-derived (developability)

Computed from the representative peptidoform's chemical structure. Rule-of-5 / beyond-Ro5 framing per Lipinski/Doak.

Topological polar surface area
159.7 Ų
Computed logP (Crippen)
2.94

Computed logP — distinct from the measured logD endpoint.

Hydrogen-bond donors
3
Hydrogen-bond acceptors
7
Rotatable bonds
9
Rule-of-5 / beyond-Ro5 flags
Beyond Ro5 · within bRo5 oral space

1 Ro5 violation · MW 726.96 Da

03

Distribution / Barrier

2 records

What is known about distribution, binding, permeability, or barrier crossing?

Evidence records
2
Complete canonical measurements and observations attached to this domain.
Endpoint scope
1
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
1
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
0
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopePermeability
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
1
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
0
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
1
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Permeability2 records · 1 matched-context · 0 as reported · 0 context only · 1 review required
#ValueAnalysis useAssay / modelResult contextReference
1

-4.79 source-reported log Papp

Eligible when experimental context matches

RRCK · RRCK

Result: Reported point value · Molecular form: ATLPF0000511 · Source: Primary reference linked

Reference
2

-5.09 source-reported log Papp

Review experimental context before comparison

Not specified

Result: Reported point value · Molecular form: ATLPF0000511 · Source: Primary reference linked

Reference
Barrier and permeability assay context

PAMPA, Caco-2, MDCK/RRCK, and BBB findings are assay/model contexts under Distribution / Barrier. They should not be read as interchangeable measurements.

PAMPA
0

artificial membrane

Caco-2
0

cell monolayer

MDCK
0

cell monolayer

RRCK
1

cell monolayer

BBB
0

barrier evidence

04

Evidence landscape

2 records

Cross-domain evidence distribution and measurement-level detail; the domain modules above show evidence in context, and every row remains available for audit here.

Evidence landscape

A cross-domain view of evidence volume, scientifically permitted analysis use, and source traceability.

ADMET domain
Eligible when context matches
Interpret as reported
Supporting context only
Review before analysis
Exposure / Absorption
0 evidence records
0
0
0
0
Distribution / Barrier
2 evidence records
1
0
0
1
Metabolic & Proteolytic Stability
0 evidence records
0
0
0
0
Excretion / Persistence
0 evidence records
0
0
0
0
Toxicity / Safety
0 evidence records
0
0
0
0
Endpoint distribution

Top evidence-bearing endpoint questions.

Permeability
2
Assay context

Broad context buckets, useful before comparing values.

Barrier model
1
Unspecified
1
Traceability

Reference-link availability for measurement-level audit.

Linked reference
2
Not linked
0
All evidence index

Every evidence record remains available for audit and drilldown. Counts describe evidence volume, not confidence.

#ADMET domainEndpointReported valueCalculated PappResult typeAnalysis useAssay / modelConditionReference
1
Distribution / Barrier
Distribution
Permeability
-4.79
source-reported log Papp
1.62 x 10^-5 cm/s
Reported point valueEligible when experimental context matchesRRCKNot specified
Reference
Primary reference linked
2
Distribution / Barrier
Distribution
Permeability
-5.09
source-reported log Papp
8.13 x 10^-6 cm/s
Reported point valueReview experimental context before comparisonNot specifiedNot specified
Reference
Primary reference linked
1–2 / 2
05

Product context

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

No product association in this release

This peptide is currently interpreted from sequence, structure, physicochemical, and ADMET evidence only.

Browse products
06

Identity & reference map

2 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

·
Summary1 reference group
Identity type
reported modified sequence
Reported notation
0
Reference groups
1
Measurements
2
ATL peptide ID
ATLPC0000464
Identity concordance
Identity concordance
Exact reported notation

Reported sequence string matches the current peptide notation.

0 / 2
Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 2
Different notation

Reported notation does not resolve to the current display sequence.

0 / 2
Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

2 / 2
Reported sequence notation

No source-specific sequence notation has been captured in the current identity references.

Current identity
['L', 'Me_dAbu', 'meL', 'L', 'dP', 'meY']
Reported names
No distinct human-readable aliases are exposed.
Reference map1 reference group
Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

ReferenceSupportsReported identityRecords
Reference
Open
Distribution
Permeability
No reported alias
2 identity
2 evidence
07

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

·
Record scopePublic release
ATL peptide ID
ATLPC0000464
Identity type
reported modified sequence
ADMET endpoints
1
Evidence records
2
Reference groups
1
Release view
Public release
Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements
Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint
GET /api/v1/peptides/ATLPC0000464
open
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0000464' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'
ADMETatlas
peptide evidence atlas

ADMETatlas is an open, curated atlas of ADMET evidence for therapeutic peptides — spanning developability, membrane permeability and blood–brain-barrier transport, immune-recognition context, and approved-product context. Every measurement stays linked to its original source, with stable identifiers and transparent curation, so results can be traced, cited, and reproduced.

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