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Peptide·plain sequence-like

ATLPC0022593

ATLPC0022593

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR

Compare in workbenchDownload releaseAPI JSON
  • Length
    74 aa
  • Monoisotopic mass
    8445.6 Da
  • Net charge @ pH 7.4
    0.10
  • Isoelectric point
    7.54
  • GRAVY
    -0.492
On this page
  • 01 Sequence & molecular identity
  • 02 Physicochemical profile
  • 03 Evidence landscape
  • 04 Product context
  • 05 Identity & reference map
  • 06 Data access & reproducibility
Coveragecounts only · not riskATLPC0022593
  • Measurements
    0
  • Endpoints
    0
  • Domains
    0/5
  • Products
    —
  • No matrix stability evidence
  • No clearance evidence
  • No immunogenicity context
  • 2 liability motifs
Jump to domain

Open the matching evidence section below

All evidence index
Exposure / Absorption
No evidence
Distribution / Barrier
No evidence
Metabolic & Proteolytic Stability
No evidence
Excretion / Persistence
No evidence
Toxicity / Safety
No evidence
01

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

·
Identity summaryCanonical sequence only
Identity status
Canonical sequence only
Residues
74
Peptidoform features
0
Documented molecular forms
1
Representations
2
Documented molecular forms1 form linked to this peptide identity
FormTopologyModificationsConnectionsRepresentationsMeasurements
ATLPF0024693———Notation only—
Residue view
Residue display
74 residues
M1Q2I3F4V5K6T7L8T9G10K11T12I13T14L15E16V17E18P19S20D21T22I23E24N25V26K27A28K29I30Q31D32K33E34G35I36P37P38D39Q40Q41R42L43I44F45A46G47K48Q49L50E51D52G53R54T55L56S57D58Y59N60I61Q62K63E64S65T66L67H68L69V70L71R72L73R74
Side-chain classNonpolarPolarBasic (+)Acidic (−)Modified

Soft tints mark standard side-chain classes for scanning. Primary emphasis is reserved for reported modifications, termini, secondary-structure tracks, and topology links.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

·
Chemical representationsequence / HELM only
Representation class

How the current release can interpret this identity chemically.

plain sequence-like
Parent-residue sequence

Residue string used for positional interpretation when available.

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR
HELM

Polymer notation for modified peptide representation when available.

Not available
SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available
No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure referencesnone attached
3D structure not available

A 3D structure isn't available for this peptide in the current release. Chemistry and topology fields remain available when represented by sequence, HELM, or SMILES.

Covalent topology & modificationsnone
Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

02

Physicochemical profile

4 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

·
Core descriptors74 aa · pI 7.5 · GRAVY -0.49
Length
74 aa
Monoisotopic mass
8445.57 Da
Average mass
8450.74 Da
Net charge at pH 7.4
0.10
Estimated pI
7.54
GRAVY
-0.492
KD-positive residues
33.8%
Aromatic residues
4.1%
Developability interpretation
Ionization context
pH 7.4 close to pI
Hydrophobicity balance
Leans hydrophilic
Amphipathic moment (μH)
0.22
Computation boundary
Standard-sequence only
Charge & residue composition
pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2
12.87
pH 5
2.05
pH 6
0.88
pH 7.4
0.05
pH 9
-0.90
pH 12
-9.53
Residue-class composition

Grouped composition is often more interpretable than a long amino-acid list.

Acidic (D,E)
11 · 14.9%
Basic (K,R,H)
12 · 16.2%
Polar uncharged (N,Q,S,T)
18 · 24.3%
Hydrophobic aliphatic (A,V,I,L,M)
23 · 31.1%
Aromatic (F,W,Y)
3 · 4.1%
Conformational / sulfur (G,P,C)
7 · 9.5%
Top residues
L912.2%I79.5%K79.5%T79.5%E68.1%Q68.1%D56.8%R45.4%
Hydropathy & amphipathic windows
Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window
67-73
LHLVLRL
GRAVY 1.671
Most hydrophilic window
48-54
KQLEDGR
GRAVY -2.214
68 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.
Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

12 aa window
21-32
DTIENVKAKIQD
μH 1.74 · charge -1.0
12 aa window
20-31
SDTIENVKAKIQ
μH 1.49 · charge 0.0
15 aa window
18-32
EPSDTIENVKAKIQD
μH 1.39 · charge -2.0
12 aa window
41-52
QRLIFAGKQLED
μH 1.35 · charge 0.0
12 aa window
22-33
TIENVKAKIQDK
μH 1.27 · charge 1.0
Sequence-liability cues
Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

Asp isomerization motif
DG, DT · pos 21, 52
Asp-containing motifs can merit review for isomerization or related degradation pathways.
Oxidation-sensitive residues
M · pos 1
Met, Trp, and Cys residues can merit formulation review for oxidation or covalent-state sensitivity.
Alpha-helix amphipathic projection
Helical wheel · Edmundson projection
μH = 0.22100°/residue · 74 aa
μH1: M (Met) · Hydrophobic · K-D 1.9M12: Q (Gln) · Polar · K-D -3.5Q3: I (Ile) · Hydrophobic · K-D 4.5I4: F (Phe) · Aromatic · K-D 2.8F5: V (Val) · Hydrophobic · K-D 4.2V56: K (Lys) · Basic + · K-D -3.9K7: T (Thr) · Polar · K-D -0.7T8: L (Leu) · Hydrophobic · K-D 3.8L9: T (Thr) · Polar · K-D -0.7T10: G (Gly) · Special · K-D -0.4G1011: K (Lys) · Basic + · K-D -3.9K12: T (Thr) · Polar · K-D -0.7T13: I (Ile) · Hydrophobic · K-D 4.5I14: T (Thr) · Polar · K-D -0.7T15: L (Leu) · Hydrophobic · K-D 3.8L1516: E (Glu) · Acidic − · K-D -3.5E17: V (Val) · Hydrophobic · K-D 4.2V18: E (Glu) · Acidic − · K-D -3.5E19: P (Pro) · Special · K-D -1.6P20: S (Ser) · Polar · K-D -0.8S2021: D (Asp) · Acidic − · K-D -3.5D22: T (Thr) · Polar · K-D -0.7T23: I (Ile) · Hydrophobic · K-D 4.5I24: E (Glu) · Acidic − · K-D -3.5E25: N (Asn) · Polar · K-D -3.5N2526: V (Val) · Hydrophobic · K-D 4.2V27: K (Lys) · Basic + · K-D -3.9K28: A (Ala) · Hydrophobic · K-D 1.8A29: K (Lys) · Basic + · K-D -3.9K30: I (Ile) · Hydrophobic · K-D 4.5I3031: Q (Gln) · Polar · K-D -3.5Q32: D (Asp) · Acidic − · K-D -3.5D33: K (Lys) · Basic + · K-D -3.9K34: E (Glu) · Acidic − · K-D -3.5E35: G (Gly) · Special · K-D -0.4G3536: I (Ile) · Hydrophobic · K-D 4.5I37: P (Pro) · Special · K-D -1.6P38: P (Pro) · Special · K-D -1.6P39: D (Asp) · Acidic − · K-D -3.5D40: Q (Gln) · Polar · K-D -3.5Q4041: Q (Gln) · Polar · K-D -3.5Q42: R (Arg) · Basic + · K-D -4.5R43: L (Leu) · Hydrophobic · K-D 3.8L44: I (Ile) · Hydrophobic · K-D 4.5I45: F (Phe) · Aromatic · K-D 2.8F4546: A (Ala) · Hydrophobic · K-D 1.8A47: G (Gly) · Special · K-D -0.4G48: K (Lys) · Basic + · K-D -3.9K49: Q (Gln) · Polar · K-D -3.5Q50: L (Leu) · Hydrophobic · K-D 3.8L5051: E (Glu) · Acidic − · K-D -3.5E52: D (Asp) · Acidic − · K-D -3.5D53: G (Gly) · Special · K-D -0.4G54: R (Arg) · Basic + · K-D -4.5R55: T (Thr) · Polar · K-D -0.7T5556: L (Leu) · Hydrophobic · K-D 3.8L57: S (Ser) · Polar · K-D -0.8S58: D (Asp) · Acidic − · K-D -3.5D59: Y (Tyr) · Aromatic · K-D -1.3Y60: N (Asn) · Polar · K-D -3.5N6061: I (Ile) · Hydrophobic · K-D 4.5I62: Q (Gln) · Polar · K-D -3.5Q63: K (Lys) · Basic + · K-D -3.9K64: E (Glu) · Acidic − · K-D -3.5E65: S (Ser) · Polar · K-D -0.8S6566: T (Thr) · Polar · K-D -0.7T67: L (Leu) · Hydrophobic · K-D 3.8L68: H (His) · Basic + · K-D -3.2H69: L (Leu) · Hydrophobic · K-D 3.8L70: V (Val) · Hydrophobic · K-D 4.2V7071: L (Leu) · Hydrophobic · K-D 3.8L72: R (Arg) · Basic + · K-D -4.5R73: L (Leu) · Hydrophobic · K-D 3.8L74: R (Arg) · Basic + · K-D -4.5R74
Hydrophobic moment0.22
Mean K-D hydropathy-0.49
Approx. net charge0
Projection angle100° / residue
The pale sector marks the direction of the hydrophobic face inferred from μH. This is a projection assumption, not a measured fold.
HydrophobicAromaticPolarBasic +Acidic −Specialhydrophobic faceμH arrow → hydrophobic face

The projection assumes an α-helix conformation; a long μH arrow indicates an amphipathic helix, common in antimicrobial peptides.Sequence > 30 aa — only termini and every fifth position are numbered because later turns share earlier wheel angles.

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Sequence-derived

Computed from the standard parent-residue sequence; protein-origin metrics defined at any length.

Aliphatic index
102.70
Instability index
36.2

At or below 40 — predicted stable in vitro.

Boman index
2.05 kcal/mol
Molar extinction coefficient (280 nm)
1,490 M⁻¹·cm⁻¹

A280 (1 g/L) ≈ 0.18

Structure-derived descriptors are not shown because this identity has no resolved chemical structure (SMILES). This is a known coverage gap for disulfide-rich and unresolved peptidoforms, not a computation error.

03

Evidence landscape

Cross-domain evidence distribution and measurement-level detail. No assay-level evidence is available for this peptide in the current release.

No endpoint-level measurements returned

No ADMET endpoint evidence is attached to this peptide yet.

/evidence/drilldown
04

Product context

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

No product association in this release

This peptide is currently interpreted from sequence, structure, physicochemical, and ADMET evidence only.

Browse products
05

Identity & reference map

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

No identity references available

No reported identity references are available for this peptide in the current release.

06

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

·
Record scopePublic release
ATL peptide ID
ATLPC0022593
Identity type
canonical sequence
ADMET endpoints
0
Evidence records
0
Reference groups
1
Release view
Public release
Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements
Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint
GET /api/v1/peptides/ATLPC0022593
open
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0022593' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'
ADMETatlas
peptide evidence atlas

ADMETatlas is an open, curated atlas of ADMET evidence for therapeutic peptides — spanning developability, membrane permeability and blood–brain-barrier transport, immune-recognition context, and approved-product context. Every measurement stays linked to its original source, with stable identifiers and transparent curation, so results can be traced, cited, and reproduced.

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