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Peptide·plain sequence-like

ATLPC0027334

ATLPC0027334

VPIDVDKTKVHNVEPVESARIEPPDTGLYYDEYLKQVIEVLETDPHFREKLQKADIEEIRSGRLSQELDLVSHKVRTRLD…

Routes
Compare in workbenchDownload releaseAPI JSON
  • Length
    82 aa
  • Monoisotopic mass
    9577.0 Da
  • Net charge @ pH 7.4
    -6.70
  • Isoelectric point
    4.60
  • GRAVY
    -0.711
On this page
  • 01 Sequence & molecular identity
  • 02 Physicochemical profile
  • 03 Distribution / Barrier
  • 04 Evidence landscape
  • 05 Product context
  • 06 Identity & reference map
  • 07 Data access & reproducibility
Coveragecounts only · not riskATLPC0027334
  • Measurements
    26
  • Endpoints
    1
  • Domains
    1/5
  • Products
    —
  • No matrix stability evidence
  • No clearance evidence
  • No immunogenicity context
  • 1 liability motif
Jump to domain

Open the matching evidence section below

All evidence index · 26
Exposure / Absorption
No evidence
Distribution / Barrier
26 measurements
Metabolic & Proteolytic Stability
No evidence
Excretion / Persistence
No evidence
Toxicity / Safety
No evidence
01

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

·
Identity summaryCanonical sequence only
Identity status
Canonical sequence only
Residues
82
Peptidoform features
0
Documented molecular forms
1
Representations
2
Documented molecular forms1 form linked to this peptide identity
FormTopologyModificationsConnectionsRepresentationsMeasurements
ATLPF0029700———Notation only—
Residue view
Residue display
82 residues
V1P2I3D4V5D6K7T8K9V10H11N12V13E14P15V16E17S18A19R20I21E22P23P24D25T26G27L28Y29Y30D31E32Y33L34K35Q36V37I38E39V40L41E42T43D44P45H46F47R48E49K50L51Q52K53A54D55I56E57E58I59R60S61G62R63L64S65Q66E67L68D69L70V71S72H73K74V75R76T77R78L79D80E81L82
Side-chain classNonpolarPolarBasic (+)Acidic (−)Modified

Soft tints mark standard side-chain classes for scanning. Primary emphasis is reserved for reported modifications, termini, secondary-structure tracks, and topology links.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

·
Chemical representationsequence / HELM only
Representation class

How the current release can interpret this identity chemically.

plain sequence-like
Parent-residue sequence

Residue string used for positional interpretation when available.

VPIDVDKTKVHNVEPVESARIEPPDTGLYYDEYLKQVIEVLETDPHFREKLQKADIEEIRSGRLSQELDLVSHKVRTRLDEL
HELM

Polymer notation for modified peptide representation when available.

Not available
SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available
No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure referencesnone attached
3D structure not available

A 3D structure isn't available for this peptide in the current release. Chemistry and topology fields remain available when represented by sequence, HELM, or SMILES.

Covalent topology & modificationsnone
Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

02

Physicochemical profile

4 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

·
Core descriptors82 aa · pI 4.6 · GRAVY -0.71
Length
82 aa
Monoisotopic mass
9577.02 Da
Average mass
9582.79 Da
Net charge at pH 7.4
-6.70
Estimated pI
4.60
GRAVY
-0.711
KD-positive residues
31.7%
Aromatic residues
4.9%
Developability interpretation
Ionization context
pH 7.4 separated from pI
Hydrophobicity balance
Leans hydrophilic
Amphipathic moment (μH)
0.03
Computation boundary
Standard-sequence only
Charge & residue composition
pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2
15.79
pH 5
-2.24
pH 6
-4.52
pH 7.4
-6.72
pH 9
-8.02
pH 12
-18.05
Residue-class composition

Grouped composition is often more interpretable than a long amino-acid list.

Acidic (D,E)
19 · 23.2%
Basic (K,R,H)
15 · 18.3%
Polar uncharged (N,Q,S,T)
12 · 14.6%
Hydrophobic aliphatic (A,V,I,L,M)
25 · 30.5%
Aromatic (F,W,Y)
4 · 4.9%
Conformational / sulfur (G,P,C)
7 · 8.5%
Top residues
E1113.4%L911.0%V911.0%D89.8%R67.3%K67.3%I56.1%P56.1%
Hydropathy & amphipathic windows
Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window
37-43
VIEVLET
GRAVY 1.286
Most hydrophilic window
44-50
DPHFREK
GRAVY -2.486
76 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.
Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

12 aa window
32-43
EYLKQVIEVLET
μH 2.10 · charge -2.0
12 aa window
31-42
DEYLKQVIEVLE
μH 2.10 · charge -3.0
12 aa window
30-41
YDEYLKQVIEVL
μH 1.85 · charge -2.0
12 aa window
71-82
VSHKVRTRLDEL
μH 1.74 · charge 1.1
15 aa window
32-46
EYLKQVIEVLETDPH
μH 1.65 · charge -2.9
Sequence-liability cues
Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

Asp isomerization motif
DP, DT · pos 25, 44
Asp-containing motifs can merit review for isomerization or related degradation pathways.
Alpha-helix amphipathic projection
Helical wheel · Edmundson projection
μH = 0.03100°/residue · 82 aa
μH1: V (Val) · Hydrophobic · K-D 4.2V12: P (Pro) · Special · K-D -1.6P3: I (Ile) · Hydrophobic · K-D 4.5I4: D (Asp) · Acidic − · K-D -3.5D5: V (Val) · Hydrophobic · K-D 4.2V56: D (Asp) · Acidic − · K-D -3.5D7: K (Lys) · Basic + · K-D -3.9K8: T (Thr) · Polar · K-D -0.7T9: K (Lys) · Basic + · K-D -3.9K10: V (Val) · Hydrophobic · K-D 4.2V1011: H (His) · Basic + · K-D -3.2H12: N (Asn) · Polar · K-D -3.5N13: V (Val) · Hydrophobic · K-D 4.2V14: E (Glu) · Acidic − · K-D -3.5E15: P (Pro) · Special · K-D -1.6P1516: V (Val) · Hydrophobic · K-D 4.2V17: E (Glu) · Acidic − · K-D -3.5E18: S (Ser) · Polar · K-D -0.8S19: A (Ala) · Hydrophobic · K-D 1.8A20: R (Arg) · Basic + · K-D -4.5R2021: I (Ile) · Hydrophobic · K-D 4.5I22: E (Glu) · Acidic − · K-D -3.5E23: P (Pro) · Special · K-D -1.6P24: P (Pro) · Special · K-D -1.6P25: D (Asp) · Acidic − · K-D -3.5D2526: T (Thr) · Polar · K-D -0.7T27: G (Gly) · Special · K-D -0.4G28: L (Leu) · Hydrophobic · K-D 3.8L29: Y (Tyr) · Aromatic · K-D -1.3Y30: Y (Tyr) · Aromatic · K-D -1.3Y3031: D (Asp) · Acidic − · K-D -3.5D32: E (Glu) · Acidic − · K-D -3.5E33: Y (Tyr) · Aromatic · K-D -1.3Y34: L (Leu) · Hydrophobic · K-D 3.8L35: K (Lys) · Basic + · K-D -3.9K3536: Q (Gln) · Polar · K-D -3.5Q37: V (Val) · Hydrophobic · K-D 4.2V38: I (Ile) · Hydrophobic · K-D 4.5I39: E (Glu) · Acidic − · K-D -3.5E40: V (Val) · Hydrophobic · K-D 4.2V4041: L (Leu) · Hydrophobic · K-D 3.8L42: E (Glu) · Acidic − · K-D -3.5E43: T (Thr) · Polar · K-D -0.7T44: D (Asp) · Acidic − · K-D -3.5D45: P (Pro) · Special · K-D -1.6P4546: H (His) · Basic + · K-D -3.2H47: F (Phe) · Aromatic · K-D 2.8F48: R (Arg) · Basic + · K-D -4.5R49: E (Glu) · Acidic − · K-D -3.5E50: K (Lys) · Basic + · K-D -3.9K5051: L (Leu) · Hydrophobic · K-D 3.8L52: Q (Gln) · Polar · K-D -3.5Q53: K (Lys) · Basic + · K-D -3.9K54: A (Ala) · Hydrophobic · K-D 1.8A55: D (Asp) · Acidic − · K-D -3.5D5556: I (Ile) · Hydrophobic · K-D 4.5I57: E (Glu) · Acidic − · K-D -3.5E58: E (Glu) · Acidic − · K-D -3.5E59: I (Ile) · Hydrophobic · K-D 4.5I60: R (Arg) · Basic + · K-D -4.5R6061: S (Ser) · Polar · K-D -0.8S62: G (Gly) · Special · K-D -0.4G63: R (Arg) · Basic + · K-D -4.5R64: L (Leu) · Hydrophobic · K-D 3.8L65: S (Ser) · Polar · K-D -0.8S6566: Q (Gln) · Polar · K-D -3.5Q67: E (Glu) · Acidic − · K-D -3.5E68: L (Leu) · Hydrophobic · K-D 3.8L69: D (Asp) · Acidic − · K-D -3.5D70: L (Leu) · Hydrophobic · K-D 3.8L7071: V (Val) · Hydrophobic · K-D 4.2V72: S (Ser) · Polar · K-D -0.8S73: H (His) · Basic + · K-D -3.2H74: K (Lys) · Basic + · K-D -3.9K75: V (Val) · Hydrophobic · K-D 4.2V7576: R (Arg) · Basic + · K-D -4.5R77: T (Thr) · Polar · K-D -0.7T78: R (Arg) · Basic + · K-D -4.5R79: L (Leu) · Hydrophobic · K-D 3.8L80: D (Asp) · Acidic − · K-D -3.5D8081: E (Glu) · Acidic − · K-D -3.5E82: L (Leu) · Hydrophobic · K-D 3.8L82
Hydrophobic moment0.03
Mean K-D hydropathy-0.71
Approx. net charge-7
Projection angle100° / residue
The pale sector marks the direction of the hydrophobic face inferred from μH. This is a projection assumption, not a measured fold.
HydrophobicAromaticPolarBasic +Acidic −Specialhydrophobic faceμH arrow → hydrophobic face

The projection assumes an α-helix conformation; a long μH arrow indicates an amphipathic helix, common in antimicrobial peptides.Sequence > 30 aa — only termini and every fifth position are numbered because later turns share earlier wheel angles.

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Sequence-derived

Computed from the standard parent-residue sequence; protein-origin metrics defined at any length.

Aliphatic index
100.85
Instability index
59.4

Above 40 — predicted unstable in vitro.

Boman index
2.63 kcal/mol

Above 2.48 — elevated potential protein-binding.

Molar extinction coefficient (280 nm)
4,470 M⁻¹·cm⁻¹

A280 (1 g/L) ≈ 0.47

Structure-derived descriptors are not shown because this identity has no resolved chemical structure (SMILES). This is a known coverage gap for disulfide-rich and unresolved peptidoforms, not a computation error.

03

Distribution / Barrier

26 records

What is known about distribution, binding, permeability, or barrier crossing?

Evidence records
26
Complete canonical measurements and observations attached to this domain.
Endpoint scope
1
Formal ADMET endpoints represented for this peptide.
Matched-context in preview
2
Quantitative results that may be analysed only with scientifically compatible records.
Reported results in preview
18
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeBBB penetration
Loading 26 Distribution / Barrier records…
Barrier and permeability assay context

PAMPA, Caco-2, MDCK/RRCK, and BBB findings are assay/model contexts under Distribution / Barrier. They should not be read as interchangeable measurements.

PAMPA
0

artificial membrane

Caco-2
0

cell monolayer

MDCK
0

cell monolayer

RRCK
0

cell monolayer

BBB
20

barrier evidence

04

Evidence landscape

26 records

Cross-domain evidence distribution and measurement-level detail. 20 of 26 evidence records are included in the profile preview; the full index is loaded below.

Loading 26 measurements…
05

Product context

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

No product association in this release

This peptide is currently interpreted from sequence, structure, physicochemical, and ADMET evidence only.

Browse products
06

Identity & reference map

26 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

·
Summary2 reference groups
Identity type
canonical sequence
Reported notation
1
Reference groups
2
Measurements
26
ATL peptide ID
ATLPC0027334
Identity concordance
Identity concordance
Exact reported notation

Reported sequence string matches the current peptide notation.

6 / 26
Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 26
Different notation

Reported notation does not resolve to the current display sequence.

0 / 26
Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

20 / 26
Reported sequence notation
Exact6 references
VPIDVDKTKVHNVEPVESARIEPPDTGLYYDEYLKQVIEVLETDPHFREKLQKADIEEIRSGRLSQELDLVSHKVRTRLDEL
Current identity
VPIDVDKTKVHNVEPVESARIEPPDTGLYYDEYLKQVIEVLETDPHFREKLQKADIEEIRSGRLSQELDLVSHKVRTRLDEL
Reported names
brainpeps_observation_v2_48_2_2_13c72da10c9daf16fa09brainpeps_observation_v2_48_2_2_500cec6aeba6a2264228brainpeps_observation_v2_48_2_36_1fd97dd3864e6db11babbrainpeps_observation_v2_48_2_36_f948495abbe31417bde4brainpeps_observation_v2_48_5_4_6b368e5cacc9f0afcb4cbrainpeps_observation_v2_48_5_4_ea991920e2b090de68f9
Reference map2 reference groups
Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

ReferenceSupportsReported identityRecords
Reference
Open
Distribution
Blood Brain Barrier Penetration
brainpeps_observation_v2_48_2_2_13c72da10c9daf16fa09, brainpeps_observation_v2_48_2_36_1fd97dd3864e6db11bab, brainpeps_observation_v2_48_5_4_6b368e5cacc9f0afcb4c
VPIDVDKTKVHNVEPVESA...LSQELDLVSHKVRTRLDELexact
16 identity
13 evidence
Reference
Open
Distribution
Blood Brain Barrier Penetration
brainpeps_observation_v2_48_2_2_500cec6aeba6a2264228, brainpeps_observation_v2_48_2_36_f948495abbe31417bde4, brainpeps_observation_v2_48_5_4_ea991920e2b090de68f9
VPIDVDKTKVHNVEPVESA...LSQELDLVSHKVRTRLDELexact
10 identity
7 evidence
07

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

·
Record scopePublic release
ATL peptide ID
ATLPC0027334
Identity type
canonical sequence
ADMET endpoints
1
Evidence records
26
Reference groups
2
Release view
Public release
Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements
Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint
GET /api/v1/peptides/ATLPC0027334
open
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0027334' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'
ADMETatlas
peptide evidence atlas

ADMETatlas is an open, curated atlas of ADMET evidence for therapeutic peptides — spanning developability, membrane permeability and blood–brain-barrier transport, immune-recognition context, and approved-product context. Every measurement stays linked to its original source, with stable identifiers and transparent curation, so results can be traced, cited, and reproduced.

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