ATLPC0029431

ATLPC0029431 — ADMETatlas

Computed descriptors

Core descriptors20 aa · pI 4.2 · GRAVY -0.56

Length: 20 aa
Monoisotopic mass: 2178.01 Da
Average mass: 2179.39 Da
Net charge at pH 7.4: -1.00
Estimated pI: 4.18
GRAVY: -0.565
KD-positive residues: 25.0%
Aromatic residues: 10.0%

Developability interpretation

Ionization context: pH 7.4 separated from pI
Hydrophobicity balance: Leans hydrophilic
Amphipathic moment (μH): 0.33
Computation boundary: Standard-sequence only

Charge & residue composition

pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2

1.96

pH 5

-0.78

pH 6

-0.98

pH 7.4

Hydropathy & amphipathic windows

Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window

1-7

GETAMTI

GRAVY 0.414

Most hydrophilic window

14-20

SNIDTSK

GRAVY -1.243

14 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.

Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

Sequence-liability cues

Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

Asn deamidation motif

NG · pos 8

Asn followed by small/polar residues is a known sequence context to review for deamidation susceptibility.

Asp isomerization motif

DT · pos 17

Asp-containing motifs can merit review for isomerization or related degradation pathways.

Oxidation-sensitive residues

M, W · pos 5, 11, 13

Met, Trp, and Cys residues can merit formulation review for oxidation or covalent-state sensitivity.

Alpha-helix amphipathic projection

Helical wheel · Edmundson projection

μ_H = 0.33100°/residue · 20 aa

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

5. Metabolic & Proteolytic Stability

How stable is the peptide in biological matrices or protease systems?

Evidence summary

Measurements

Measurements, observations, and support attached to this domain.

Endpoint scope

Formal ADMET endpoints represented for this peptide.

Comparable measurements

Rows suitable for comparison only within matching endpoint and assay context.

Reported observations

Reviewed observations retained without being collapsed into comparable values.

Domain scope

Endpoints define the scientific questions in this domain; the measurements below carry the values and assay context.

Protease stability

Serum/plasma stability and protease stability evidence.

Evidence interpretation

The same three research-facing layers are used across ADMETatlas.

Comparable measurements

Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

Protease stability2 measurements · 0 comparable · 2 reported · 0 contextual

#	Value	Evidence layer	Assay / model	Condition	Reference
1	Observation N.A.	Reported	LC-MS	Dose/window: 20 μM · Time: Wild-type and mutant MBP samples were collected after 1, 3, 6, 9, and 12 and 1, 3, 5, 7, 9, and 12 calendar m... · Pepsin · In Vitro	Open
2	Observation N.A.	Reported	LC-MS	Dose/window: 20 μM · Time: Wild-type and mutant MBP samples were collected after 1, 3, 6, 9, and 12 and 1, 3, 5, 7, 9, and 12 calendar m... · Trypsin · In Vitro	Open

Interpretation: In vitro stability, protease stability, and percent-remaining measurements are not collapsed into one value.

Evidence landscape and measurement index

Evidence landscape

A cross-domain view of where evidence is concentrated, which interpretation layers dominate, and how traceable the measurements are.

ADMET domain

Comparable

Reported

Contextual

Exposure / Absorption

0 measurements

Distribution / Barrier

0 measurements

Metabolic & Proteolytic Stability

2 measurements

Excretion / Persistence

0 measurements

Toxicity / Safety

0 measurements

Endpoint distribution

Top evidence-bearing endpoint questions.

Protease Stability

Assay context

Broad context buckets, useful before comparing values.

Matrix / stability

Traceability

Reference-link availability for measurement-level audit.

Linked reference

Not linked

All evidence index

Every measurement remains available for audit and drilldown. Counts describe evidence volume, not confidence.

DomainLayerReference

#	ADMET domain	Endpoint	Reported value	Evidence layer	Assay / model	Condition	Reference
1	Metabolic & Proteolytic Stability Stability	Protease Stability	Observation N.A.	Contextual	LC-MS	Time: Wild-type and mutant MBP samples were collected after 1, 3, 6, 9, and 12 and 1, 3, 5, 7, 9, and 12 calendar months,pH 7.0 at 23 ± 2C · Dose/window: 20 μM · Protease: Trypsin · In Vit...	Open
2	Metabolic & Proteolytic Stability Stability	Protease Stability	Observation N.A.	Contextual	LC-MS	Time: Wild-type and mutant MBP samples were collected after 1, 3, 6, 9, and 12 and 1, 3, 5, 7, 9, and 12 calendar months,pH 7.0 at 23 ± 2C · Dose/window: 20 μM · Protease: Pepsin · In Vitro	Open

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Identity & reference map

Summary1 reference group

Identity type: canonical sequence
Reported notation: 1
Reference groups: 1
Measurements: 2
ATL peptide ID: ATLPC0029431

Identity concordance

Exact reported notation

Reported sequence string matches the current peptide notation.

2 / 2

Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 2

Different notation

Reported notation does not resolve to the current display sequence.

0 / 2

Reference map1 of 1 shown

Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

Reference	Supports	Reported identity	Records
PubMed 30684538 Open	Stability Protease Stability	No reported alias GETAMTINGPWAWSNIDTSKexact	2 identity 2 evidence

Interpretation: Reference links and reported notations help confirm that measurements point to the same peptide identity or a compatible peptidoform. ADMET interpretation still belongs to the endpoint modules above, where assay/model and condition context are shown with each measurement.

Data access & reproducibility

Record scopePublic release

ATL peptide ID: ATLPC0029431
Identity type: canonical sequence
ADMET endpoints: 1
Measurements: 2
Reference groups: 1
Release view: Public release

Analysis-ready files

Peptide record

TSV

Identity, sequence, profile-level fields, and current release view metadata.

Download record

Programmatic access

The request returns the same structured peptide record used by this profile. Measurement downloads use the same peptide identifier and public release visibility.

Open endpoint

GET /api/v1/peptides/ATLPC0029431

open

curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0029431' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'

Interpretation: Use these files as the reproducible data package for this peptide profile. Cross-peptide comparison still depends on compatible endpoints, assays, species or model systems, route, dose, matrix, and evidence layer.

ATLPC0029431

Peptide developability profile

1. Sequence & peptidoform

Sequence interpretation

2. Structure & chemistry

Structure and chemistry interpretation

3. Physicochemical profile

Computed descriptors

Computed developability descriptors

4. Product context

Translational product context

5. Metabolic & Proteolytic Stability

Evidence summary

6. Evidence landscape

Evidence landscape and measurement index

7. Identity & reference map

Identity & reference map

8. Data access & reproducibility

Data access & reproducibility

Peptide record

Evidence table

Structured record