ATLPD0000066
Scientific evidence profile for the complete molecular form, its ADMET and PK evidence, clinical context, safety context, and source lineage.
Product identity and molecular form, PK exposure evidence, safety context, clinical and label context, interpretation boundaries, and reproducibility exits available for this product.
What is the complete molecular form, how is it organized, and which sources define it?
What is the drug used for and how does it act?
Are there curated exposure / PK summaries or cited observations?
What safety, postmarketing, and immune-recognition signals surround the product?
What trial and product-label context is attached to this product?
How is the evidence scoped, traced, cited, and reopened?
What the product is, how its complete molecular form is defined, and which chemical or structural representations support that identity.
This record anchors the complete source-defined molecular form to product names, formulation, clinical context, and measured evidence.
These anchors support product-level lookup and context attachment. They are identity evidence, not ADMET endpoint measurements.
ATC classification © WHO Collaborating Centre for Drug Statistics Methodology; used unmodified for non-commercial research.
One complete molecular form assembled from a fixed set of source-defined components.
ADMET measurements on this page describe the complete Lutetium Lu 177 dotatate form unless a cited source explicitly identifies an individual component as the measured material.
Source-defined parts of the complete molecular form.
Source-supported links that define the complete assembly.
{"assembly_nature":"coordination","components":[{"dota_is_covalently_internal":true,"identity_target_type":"form","linked_peptidoform_atl_id":"ATLPF0039701","ordinal":1,"role":"chelator_peptide_ligand"},{"identity_target_type":"source_only","nuclide":"177Lu","ordinal":2,"oxidation_state":3,"role":"coordinated_radionuclide"}],"connection":{"component_ordinals":[1,2],"donor_atom_mapping_asserted":false,"geometry_asserted":false,"type":"coordination"},"definition_precision":"partially_defined","pubchem_representation_boundary":{"component_charge_balance":0,"coordination_bonds_explicit_in_pubchem_line_notation":false,"inchi_has_isotope_layer":true,"interpretation":"PubChem preserves isotope and charge identity but serializes the ligand and Lu-177 ion as disconnected line-notation components.","product_ligand_fragment_matches_cid_91936729":true,"product_lutetium_fragment_matches_cid_46829796":true,"smiles_component_count":2,"smiles_lutetium_component":"[177Lu+3]"},"scope":"fixed_assembly"}The topology represents the complete source-defined assembly. Component sequences and covalent connections are shown together because no single chain represents the product.
What the drug is used for and how it acts, based on curated therapeutic indications and mechanism-of-action evidence for the product identity.
4 cited PK observations with direct measurement trace.
Cited values describe the multi-component product as tested.
| PK property | Value | Context | Reference | Measured material | Evidence role | Reported statement |
|---|---|---|---|---|---|---|
| Bioavailability | Immediately and completely bioavailable | human · intravenous · Lutathera solution for infusion | Reference | Whole product | Source-reported observation | Reference entry retained for traceability. |
| PPB | 43 % | human · plasma | Reference | Whole product | Source-reported observation | Reference entry retained for traceability. |
| PPB | ≈50 % | human · plasma | Reference | Whole product | Source-reported observation | Reference entry retained for traceability. |
| Tmax | Mean Cmax generally occurred at the end of the infusion | human · intravenous · plasma | Reference | Whole product | Source-reported observation | Reference entry retained for traceability. |
Source observations remain at their reported endpoint and context. Whole-product values stay attached to the complete product.
Regulatory safety warnings, postmarketing and nonclinical safety context, and immune-recognition context. These describe available signals, not incidence rates or causality.
Clinical-trial context and structured product-label references attached by product identity.
How to read, trace, cite, and reopen this profile: evidence scope, reference lineage, and reproducible data access.
Endpoint summaries, product-context lanes, identity links, and source references answer different questions. This boundary keeps the page useful without converting context into stronger claims than the current review layer supports.
Compare PK results only when endpoint and experimental context are compatible.
Label, trial, safety, immune, and nonclinical records remain contextual unless separately extracted as an endpoint.
Product measurements remain attached to the complete form.
Comparable measurement layer
Endpoint-level interpretation when context fields match.
Pooled product parameters across mismatched species, units, route, dose, matrix, population, or source context.
Clinical, label, safety, immune, and nonclinical context
Reading the product's evidence surroundings and source-backed context lanes.
Incidence rates, causality claims, product safety ranking, or normalized ADMET endpoint values.
Measured-material boundary
Describing the complete source-defined form while retaining measurements at product level.
Transfer of a whole-product result to one component.
Reproducibility and source trace
Checking where labels, trials, safety reports, identity links, and curated measurements came from.
A substitute for normalized evidence, context grouping, or endpoint review.
Original-source reading path
Reading the source reference in its native regulatory, registry, literature, or source context.
Bypassing ADMETatlas curation status, interpretation boundaries, or endpoint-promotion policy.
Label, trial, safety, immune, identity-link, and PK evidence enter the product profile through different review paths. This module keeps their roles visible so users can trace evidence without over-reading context counts.
active reference families
source-matching traces
PK plus context entries
current product profile
Regulatory product-label context
Label sections, label-derived PK statements, safety wording, route, formulation, and immunogenicity context when extracted.
Label material supports product context. It becomes endpoint evidence only through the reviewed PK or endpoint extraction path.
Human study-registration context
Trial identity, phase/status, intervention matching, and availability of results context around the product.
Trial registry entries are study context unless endpoint-compatible results are extracted and reviewed separately.
Safety surveillance context
Signal-aware reading of reported adverse-event context around marketed products.
Report counts do not establish causality, incidence, or comparative product safety.
Assay and nonclinical support context
Immune-recognition assays, nonclinical safety context, and neighboring signals that help interpret the product profile.
These entries are not clinical incidence or endpoint truth unless a review policy promotes a specific endpoint.
Named-product identity support
Matching named and dosed product presentations to a stable medication identity.
Identity records do not provide an endpoint value, administration outcome, or route-specific clinical result.
Source-matching and identity-review context
Source records used to assess product-to-peptide identity relationships and retained audit context.
Only an exact match to the current authoritative canonical identity supports a linked identity; all other traces remain product context.
Endpoint measurement trace
Rechecking source values, units, route, dose, matrix, population, and source context for PK summaries.
PK entries remain context-bound measurements and should not be pooled across incompatible contexts.
Link references and selected label entries carry direct source links. Product-context entries may instead carry source labels and curated summaries in the structured profile. Both are provenance, but only direct reference fields should be displayed as citation links.
The structured profile access reopens the same product view used by this page, including molecular identity, PK evidence, product context, and reference lineage for the current public release.
public product profile
ATLPF0039702
cited measurement trace
37 context · 2 identity support
label plus link traces
Use the product profile access for product-specific reproducibility. Use full-release downloads for catalog-scale analysis, with the current source policy and data dictionary.
Current product
Machine-readable profile for molecular identity, PK evidence summaries, product context, and reference lineage.
Uses the public ATL product ID in the URL. Non-public product identifiers remain outside the navigation label.
The request returns the structured product profile used by this page. It is the current product-specific reproducibility path while product-only tabular exports remain a release follow-up.
curl -sS 'https://admetatlas.scbdd.com/api/v1/products/ATLPD0000066' \
-H 'accept: application/json' \
-H 'X-Visibility: public_release'Use this module to reproduce the current product profile and locate full-release exports. Cross-product comparison still depends on compatible endpoint, species, route, dose, matrix, population, source, identity-link, and review context.