Hydrogen-bond donors

hbd_lipinski · Structure-derived

Count of N-H and O-H donors (Lipinski Rule-of-5 definition). For cyclic peptides, the dominant single determinant of passive membrane permeability. 100% match vs CycPeptMPDB.

Computed value — a deterministic descriptor validated against independent reference implementations; not an experimental measurement, and it carries no evidence support-class. Computed from the chemical structure (RDKit) for peptide-scale molecules (MW ≤ 10 kDa). Not available for peptidoforms without a resolved structure (SMILES) — e.g. many disulfide-rich peptides.

• Peptides
  14,327
• Min
  0