hbd_lipinski
Count of N-H and O-H donors (Lipinski Rule-of-5 definition). For cyclic peptides, the dominant single determinant of passive membrane permeability. 100% match vs CycPeptMPDB.
Calculated from chemical structure (RDKit) when a peptide-scale SMILES is available (MW ≤ 10 kDa). Values appear on peptide records under the physicochemical profile.
Peptides with the highest values for this descriptor (of 14,327 computed). Each links to its peptide page.
| Peptide | Sequence | Value |
|---|---|---|
| ATLPC0035611 | GWPAYPGPNGIRSSVCQTKLGCGKKNLATKGV | 144 |
| ATLPC0006307 | TDTNVIGECFDEWSRCHRQTRWWTKILFQSCE | 142 |
| ATLPC0006561 | TDTNVIGECFDEWSRCHRQTRWWTKILFQSCE | 142 |
| ATLPC0024530 | SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEA | 140 |
| ATLPC0017292 | SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEA | 140 |
| ATLPC0012541 | LRRLRRRLRRLRRRLRRLRRRWRRRLRRLRRR | 135 |
| ATLPC0011544 |
| LRRLRRRLRRLRRRLRRLRRRWRRRLRRLRRR |
| 135 |
| ATLPC0024786 | MFTMKKSMLLIVLLGIISLSLCEQERNADEDE | 134 |
| ATLPC0021765 | MAFLKKSLFLVLFLGIVSLSICEEEKREGEEE | 133 |
| ATLPC0024220 | RLYRKVYGRLYRKVYGRLYRKVYGRLYRKVYG | 130 |
| ATLPC0007759 | GRAMVECWMDGHCRLLCKDGEDSIIRCRNRKR | 129 |
| ATLPC0026640 | MKKKIISAILMSTVILSAAAPLSGVYALDISS | 129 |