Topological polar surface area

tpsa · Structure-derived · unit: Ų

Sum of polar (N,O) surface contributions. Strong correlate of passive permeability and oral absorption. Exact match vs CycPeptMPDB precomputed.

Computed value — a deterministic descriptor validated against independent reference implementations; not an experimental measurement, and it carries no evidence support-class. Computed from the chemical structure (RDKit) for peptide-scale molecules (MW ≤ 10 kDa). Not available for peptidoforms without a resolved structure (SMILES) — e.g. many disulfide-rich peptides.

• Peptides
  14,327
• Min
  72.96 Ų