Half-life (PK) evidence

Peptide

ATLPC0005195

Measured material

Specific molecular form

Endpoint

Half-life (PK)

ADMET domain

Excretion / Persistence

Value

124 Hours

Normalized value

446,400 seconds

Evidence role

Comparable: structured measurement intended for within-endpoint comparison when assay context matches

Assay / model

LC-MS · human · Human plasma with Normal hepatic function

Condition

Route: SC · Dose/window: 5 mg · Time: Plasma concentrations of tirzepatide measured pre-dose, and at 8, 12, 24, 48, 72, 96, 168, and 336 hours post-dose · Human Plasma Protease · In Vivo

Scientific source

DOI: 10.1007/s40262-022-01140-3

Source: PEPlife2

Open DOI

Half-life (PK) evidence

Developability

Resources

Measurement