ADMETatlas — Peptide ADMET Evidence Atlas

Evidence entries

956records·399peptides

Showing reference-linked Half-life (PK) evidence with reported value, assay context, interpretation role, and reference access kept separate.

Assay context

Evidence role

All956 Curated comparable693 Reported263

#	Endpoint	Peptide		Assay context	Evidence role	Reference
1	Half-life (PK) Excretion / Persistence	ATLPC0005805	150 hours 540,000 seconds	HPLCCultured bovine anterior pituitary cellsbovine37 °C, phosphate buffer pH 7.40.2mM	Comparable	Open
2	Half-life (PK) Excretion / Persistence	ATLPC0018730	6.78 minutes 406.8 seconds	RadioimmunoassayIntravenous injection of oxytocin in normal mares60 minutes90mg	Comparable	Open
3	Half-life (PK) Excretion / Persistence	ATLPC0027709	9.2 ± 0.5 Minutes 552 seconds	HPLCPBS solution containing all three hydrolytic enzymes (0.5 IU/mL), ACE, LAP and NEPAfter a 30 min incubation at 37°C0.1 mM	Comparable	Open
4	Half-life (PK) Excretion / Persistence	ATLPC0030804	Observation 5.9 ±2.5 (t1/2 α)	RadioimmunoassayIntravenous injected in New Zeland female rabbits5, 1, 3, 5, 7, 10, 15, 20, 30, 45, 60, 75, and 90 min, then every 30 min until 3 h postinjection, an10 μg/kg	Reported	Open
5	Half-life (PK) Excretion / Persistence	ATLPC0010013	Observation 0.2 (T1/2 Fast Release Kinetics)	Fluorescence assayProclear CompatiblesTM contact lenses37°C, Small aliquots of the solution (100 μL) were withdrawn at predetermined intervals (5, 15, 30 min, 1, 2, 4, 8, 24, 48, 72, 96, 120, 168 h)100 μM	Reported	Open
6	Half-life (PK) Excretion / Persistence	ATLPC0003166	18.5 Hours 66,600 seconds	HPLC50% w/v liver homogenateSamples (80 μL) were taken at 0, 3, 6,9, 15, 30, 45, 60, 90, 120, 180, 240, 360 and 1440 minPeptide stock solutions (120 μL) were added to pre-warmed diluted plasma (50% v/v, 1080 μL)	Comparable	Open
7	Half-life (PK) Excretion / Persistence	ATLPC0019481	Observation 260.4 ±129.8 (Metabolic half life)	RadioimmunoassayHippocampus tissues of brain of SDAT(Alzheimer's Disease Brain Bank, Bronx, NY)37 °C for 30-180 minutes50μM	Reported	Open
8	Half-life (PK) Excretion / Persistence	ATLPC0009237	56.7 hours 204,120 seconds	RadioimmunoassayMonkey (Intravenous injection)monkey4.0 mg/kg	Comparable	Open
9	Half-life (PK) Excretion / Persistence	ATLPC0029888	197 minutes 11,820 seconds	RP-HPLCSCLC cell line NCI-H3450-1080 minutes50μM	Comparable	Open
10	Half-life (PK) Excretion / Persistence	ATLPC0027791	38 Minutes 2,280 seconds	RP-HPLCPorcine liver homogenateporcine37°C0.00001 M	Comparable	Open
11	Half-life (PK) Excretion / Persistence	ATLPC0009381	15 minutes 900 seconds	HPLCRat bloodratNot available	Comparable	Open
12	Half-life (PK) Excretion / Persistence	ATLPC0013052	32.5 ± 1.4 Minutes 1,950 seconds	RP-HPLC50 mM Tris–HCl (pH 7.4) buffer + 10 ng μL−1 DPPIV37 °C0.3 nmol	Comparable	Open
13	Half-life (PK) Excretion / Persistence	ATLPC0011025	8 minutes 480 seconds	TCA precipitationRat Stomach luminal flushingrat5, 10, 20, 30 or 60 min8.6ng	Comparable	Open
14	Half-life (PK) Excretion / Persistence	ATLPC0010590	7.5 ±1.5 minutes 450 seconds	RadioimmunoassayMale Sprague-Dawley rats bloodrat1, 2, 4, 8, 16, and 32 min200 μg/kg/h	Comparable	Open
15	Half-life (PK) Excretion / Persistence	ATLPC0019865	12.61 ± 5.45 Hours 45,396 seconds	UHPLCMale SD rats thoraic lymphratSCLymph was collected continuously into tubes at specified time intervals: predose, 0–15 min, 15–30 min, 30 45 min, 45–60 min, 1–1.5 hr, 1.5–2 hr, 2–3 hr, 3–4 hr, 4–6 hr, 6–8 hr, 8–10 hr, 10–24 hr, and 24–30 hr2 mg/kg	Comparable	Open
16	Half-life (PK) Excretion / Persistence	ATLPC0008097	3.6 ±0.2 hours 12,960 seconds	HPLCGLP-1 analogue (100 μM) was incubated with the recombinant human DPP-IV enzyme (0.2 ng/mL) in Tris buffer (25 mM, pH 8.0) at 37 °Chuman24 hours100μM	Comparable	Open
17	Half-life (PK) Excretion / Persistence	ATLPC0010669	9.5 Minutes 570 seconds	RP-HPLCHeLa lysates + Assay buffer(10 mM Tris-HCl, pH 7.6)37°C2 mg/ml	Comparable	Open
18	Half-life (PK) Excretion / Persistence	ATLPC0008882	18.3 Hours 65,880 seconds	BCA protein assayMouse liver homogenatemouse37 °C100 μl/ ml	Comparable	Open
19	Half-life (PK) Excretion / Persistence	ATLPC0018357	1 minutes 60 seconds	RadioimmunoassayInsulin-treated IRAP+/+ micemouse1,2 and 3 minutes50 or 0.4 pmol of vasopressin with 33 kBq	Comparable	Open
20	Half-life (PK) Excretion / Persistence	ATLPC0023254	Observation 13.3 [12.7, 14.0]	HPLC, LC-UV/MSMouse liver homogenatemouse37 °C for 0 - 60 minutes, pH 7.1090 μg	Reported	Open

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