Evidence — ADMETatlas

Evidence entries

2,807records·988linked peptides

Showing reference-linked Half-life (PK) evidence with reported value, assay context, interpretation role, and reference access kept separate.

Assay context

Evidence role

All2,807 Curated comparable2,539 Reported268

#	Endpoint	Measured entity		Assay context	Evidence role	Reference
1	Half-life (PK) Excretion / Persistence	Peptide ATLPC0005805 Specific molecular form	150 hours 540,000 seconds	HPLCCultured bovine anterior pituitary cellsbovine0.2mM	Comparable	Reference
2	Half-life (PK) Excretion / Persistence	Peptide ATLPC0010757 Specific molecular form	164.3 seconds	RadioimmunoassayMale Wistar rats plasma (Dose i/p injected)ratBlood samples collected at 5-1800 seconds after peptide injecteion1x 106 cpm	Comparable	Reference
3	Half-life (PK) Excretion / Persistence	Peptide ATLPC0012374 Specific molecular form	240 seconds	Not specified	Comparable	Reference
4	Half-life (PK) Excretion / Persistence	Peptide ATLPC0018730 Specific molecular form	6.78 minutes 406.8 seconds	Not specified	Comparable	Reference
5	Half-life (PK) Excretion / Persistence	Peptide ATLPC0027709 Specific molecular form	9.2 ± 0.5 Minutes 552 seconds	HPLCPBS solution containing all three hydrolytic enzymes (0.5 IU/mL), ACE, LAP and NEP0.1 mM	Comparable	Reference
6	Half-life (PK) Excretion / Persistence	Peptide ATLPC0032821 Specific molecular form	0.31 Hours 1,116 seconds	ELISAKunming mice plasmamouseTail vein injection	Comparable	Reference
7	Half-life (PK) Excretion / Persistence	Peptide ATLPC0008565 Specific molecular form	46.11 Hours 165,996 seconds	Sandwich ELISARhesus monkeys plasmamonkeyIV	Comparable	Reference
8	Half-life (PK) Excretion / Persistence	Peptide ATLPC0020788 Specific molecular form	2.57 ± 0.71 Hours 9,252 seconds	Rats plasmaratSC	Comparable	Reference
9	Half-life (PK) Excretion / Persistence	Peptide ATLPC0022685 Specific molecular form	2.39 minutes 143.4 seconds	Competitive RadioimmunoassayRat plasma (Intravenous)rat10 nM/ Kg	Comparable	Reference
10	Half-life (PK) Excretion / Persistence	Peptide ATLPC0009217 Specific molecular form	47 Hours 169,200 seconds	LC-MS/MSGöttingen minipigs plasmaporcineIVBlood samples were collected before RA15127343 administration (baseline) and 1–4 times per day until study end.	Comparable	Reference
11	Half-life (PK) Excretion / Persistence	Peptide ATLPC0029360 Specific molecular form	226.02 seconds	LC-MSRats plasmaratIV2 μM	Comparable	Reference
12	Half-life (PK) Excretion / Persistence	Peptide ATLPC0030804 Specific molecular form	354 seconds	Not specified	Reported	Reference
13	Half-life (PK) Excretion / Persistence	Peptide ATLPC0023486 Specific molecular form	500,400 seconds	LC-MSBeagle dogs plasmadogPO3 mg	Comparable	Reference
14	Half-life (PK) Excretion / Persistence	Measured entity Not resolved	254 Hours 914,400 seconds	LC-MSHuman plasma after SC glepaglutide 5 mg after 6 once-weekly doseshumanSC glepaglutide 10 mg after 6 once-weekly doses10 mg	Comparable	Reference
15	Half-life (PK) Excretion / Persistence	Peptide ATLPC0010013 Specific molecular form	720 seconds	Not specified	Reported	Reference
16	Half-life (PK) Excretion / Persistence	Peptide ATLPC0003166 Specific molecular form	18.5 Hours 66,600 seconds	HPLC50% w/v liver homogenateSamples (80 μL) were taken at 0, 3, 6,9, 15, 30, 45, 60, 90, 120, 180, 240, 360 and 1440 minPeptide stock solutions (120 μL) were added to pre-warmed diluted plasma (50% v/v, 1080 μL)	Comparable	Reference
17	Half-life (PK) Excretion / Persistence	Peptide ATLPC0019481 Specific molecular form	15,624 seconds	RadioimmunoassayHippocampus tissues of brain of SDAT(Alzheimer's Disease Brain Bank, Bronx, NY)50μM	Reported	Reference
18	Half-life (PK) Excretion / Persistence	Peptide ATLPC0011025 Specific molecular form	6.0-7.0 hours 21,600-25,200 seconds	Radioimmunoassay, Binding protein radioactivity assay and IGF-region radioactivityEight merino lambs plasmaBlood collected 10 minutes to 30 hours after peptide infusion10mM/L	Reported	Reference
19	Half-life (PK) Excretion / Persistence	Peptide ATLPC0030959 Specific molecular form	305.4 seconds	LC-MS/MSMale dogs plasma After Day 1 Repeated DosedogIV, Multiple dosesSamples Were Collected At 2,5,10,20,40 Minutes After Dosing On Days 1 Or 14	Comparable	Reference
20	Half-life (PK) Excretion / Persistence	Peptide ATLPC0009237 Specific molecular form	56.7 hours 204,120 seconds	Not specified	Comparable	Reference

1–20 / 2,807

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