Plasma protein binding evidence

Peptide

ATLPC0020556

Measured material

Peptide backbone

Endpoint

Plasma protein binding

ADMET domain

Distribution / Barrier

Value

Observation

About 50% of the administered dose is taken up by erythrocytes while about 34% is bound to lipoproteins. Prescribing information for Sandimmune states that 90% is mainly bound to lipoproteins.

Evidence role

Reported: reviewed reported observation that should not be pooled as a comparable value yet

Assay / model

plasma protein

Condition

Route: TOPICAL, OPHTALMIC, IV, ORAL · 73 · Cyclosporine · exact product name match · exact or normalized match

Scientific source

PepTherDia

Open source

Plasma protein binding evidence

Developability

Resources

Measurement