Evidence — ADMETatlas

Evidence entries

156records·52linked peptides

Showing reference-linked Plasma protein binding evidence with reported value, assay context, interpretation role, and reference access kept separate.

Assay context

Evidence role

All156 Curated comparable111 Reported45

#	Endpoint	Measured entity		Assay context	Evidence role	Reference
1	Plasma protein binding Distribution / Barrier	Peptide ATLPC0027686 Specific molecular form	79-83 %	Health Canada SBD 3.3.2 pharmacokinetics manual extractionserumhumanlanreotide 12-60 ng/mL	Comparable	Reference
2	Plasma protein binding Distribution / Barrier	Peptide ATLPC0015943 Peptide backbone	~ 15 %	UK eMC SmPC section 5.2 pharmacokinetics manual extractionserumhuman	Comparable	Reference
3	Plasma protein binding Distribution / Barrier	Peptide ATLPC0004440 Peptide backbone	Observation plasma protein binding not determined due to hydrolysis of vosoritide in human plasma	FDA Integrated Review Table 5 manual extractionplasmahuman	Reported	Reference
4	Plasma protein binding Distribution / Barrier	Peptide ATLPC0007210 Specific molecular form	44 %	Not specified	Comparable	Reference
5	Plasma protein binding Distribution / Barrier	Peptide ATLPC0001542 Peptide backbone	30-40 %	Australian Medicine Finder PI 5.2 pharmacokinetics manual extractionplasmahuman	Comparable	Reference
6	Plasma protein binding Distribution / Barrier	Peptide ATLPC0024280 Peptide backbone	numeric	plasma proteinSC	Reported	Source record
7	Plasma protein binding Distribution / Barrier	Peptide ATLPC0023266 Peptide backbone	Observation Pramlintide does not extensively bind to blood cells or albumin (approximately 40% of the drug is unbound in plasma).	plasma proteinSC	Reported	Source record
8	Plasma protein binding Distribution / Barrier	Peptide ATLPC0009237 Peptide backbone	Observation Not determined	plasma proteinSC	Reported	Source record
9	Plasma protein binding Distribution / Barrier	Peptide ATLPC0025642 Peptide backbone	65 %	plasma proteinSC, IV, IM	Comparable	Source record
10	Plasma protein binding Distribution / Barrier	Peptide ATLPC0019799 Peptide backbone	70 %	plasma proteinSC	Comparable	Source record
11	Plasma protein binding Distribution / Barrier	Peptide ATLPC0019952 Peptide backbone	Observation Plecanatide exhibits little to no binding to human serum albumin or human α-1-acid glycoprotein.	plasma proteinORAL	Reported	Source record
12	Plasma protein binding Distribution / Barrier	Peptide ATLPC0011948 Peptide backbone	99 %	plasma proteinSC, ORAL	Comparable	Source record
13	Plasma protein binding Distribution / Barrier	Peptide ATLPC0005195 Peptide backbone	99 %	plasma proteinSC	Comparable	Source record
14	Plasma protein binding Distribution / Barrier	Measured entity Not resolved	43-49 %	plasma proteinSC, IM, TOPICAL	Comparable	Source record
15	Plasma protein binding Distribution / Barrier	Peptide ATLPC0021413 Peptide backbone	80 %	plasma proteinNASAL	Comparable	Source record
16	Plasma protein binding Distribution / Barrier	Peptide ATLPC0019426 Peptide backbone	86 %	plasma proteinSC	Comparable	Source record
17	Plasma protein binding Distribution / Barrier	Peptide ATLPC0015970 Peptide backbone	50 %	plasma proteinIT	Comparable	Source record
18	Plasma protein binding Distribution / Barrier	Peptide ATLPC0008117 Peptide backbone	97 %	plasma proteinIV	Comparable	Source record
19	Plasma protein binding Distribution / Barrier	Peptide ATLPC0002483 Peptide backbone	85 %	plasma proteinIV	Comparable	Source record
20	Plasma protein binding Distribution / Barrier	Peptide ATLPC0025660 Peptide backbone	21 %	plasma proteinSC	Comparable	Source record

1–20 / 156

Evidence — ADMETatlas

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