Clearance evidence

the mean CL T was 9%, 22%, and 46% lower among subjects and patients with mild (CL CR 50–80 mL/min), moderate (CL CR 30–<50 mL/min), and severe (CL CR <30 mL/min) renal impairment, respectively, than in those with normal renal function (CL CR >80 mL/min).