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Peptide·plain sequence-like

Thymalfasin

ATLPC0003634

SDAAVDTSSEITTKDLKEKKEVVEEAEN

Routes
Compare in workbenchDownload releaseAPI JSON
  • Length
    28 aa
  • Monoisotopic mass
    3064.5 Da
  • Net charge @ pH 7.4
    -5.00
  • Isoelectric point
    3.99
  • GRAVY
    -1.029
On this page
  • 01 Sequence & molecular identity
  • 02 Physicochemical profile
  • 03 Exposure / Absorption
  • 04 Distribution / Barrier
  • 05 Metabolic & Proteolytic Stability
  • 06 Evidence landscape
  • 07 Product context
  • 08 Identity & reference map
  • 09 Data access & reproducibility
Coveragecounts only · not riskATLPC0003634
  • Measurements
    6
  • Endpoints
    5
  • Domains
    3/5
  • Products
    1
  • 1 stability measurement
  • No clearance evidence
  • Product-level review pending
  • 1 liability motif
Jump to domain

Open the matching evidence section below

All evidence index · 6
Exposure / Absorption
4 measurements
Distribution / Barrier
1 measurement
Metabolic & Proteolytic Stability
1 measurement
Excretion / Persistence
No evidence
Toxicity / Safety
No evidence
01

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

·
Identity summaryCanonical sequence only
Identity status
Canonical sequence only
Residues
28
Peptidoform features
0
Documented molecular forms
1
Representations
2
Documented molecular forms1 form linked to this peptide identity
FormTopologyModificationsConnectionsRepresentationsMeasurements
ATLPF0003963———Notation only—
Residue view
Residue display
28 residues
S1D2A3A4V5D6T7S8S9E10I11T12T13K14D15L16K17E18K19K20E21V22V23E24E25A26E27N28
Side-chain classNonpolarPolarBasic (+)Acidic (−)Modified

Soft tints mark standard side-chain classes for scanning. Primary emphasis is reserved for reported modifications, termini, secondary-structure tracks, and topology links.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

·
Chemical representationsequence / HELM only
Representation class

How the current release can interpret this identity chemically.

plain sequence-like
Parent-residue sequence

Residue string used for positional interpretation when available.

SDAAVDTSSEITTKDLKEKKEVVEEAEN
HELM

Polymer notation for modified peptide representation when available.

Not available
SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available
No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure references2 references
Structure reference·
3D coordinates·Sequence matchexperimental
Sequence match·reference selected·identity 100.0%·confidence experimental
LinkMethodConfidenceMatch
OpenSequence matchexperimental100.0% identity
OpenSequence matchexperimental100.0% identity
Covalent topology & modificationsnone
Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

02

Physicochemical profile

4 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

·
Core descriptors28 aa · pI 4.0 · GRAVY -1.03
Length
28 aa
Monoisotopic mass
3064.49 Da
Average mass
3066.28 Da
Net charge at pH 7.4
-5.00
Estimated pI
3.99
GRAVY
-1.029
KD-positive residues
28.6%
Aromatic residues
0.0%
Developability interpretation
Ionization context
pH 7.4 separated from pI
Hydrophobicity balance
Leans hydrophilic
Amphipathic moment (μH)
1.07
Computation boundary
Standard-sequence only
Charge & residue composition
pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2
4.89
pH 5
-4.07
pH 6
-4.90
pH 7.4
-5.06
pH 9
-5.78
pH 12
-9.76
Residue-class composition

Grouped composition is often more interpretable than a long amino-acid list.

Acidic (D,E)
9 · 32.1%
Basic (K,R,H)
4 · 14.3%
Polar uncharged (N,Q,S,T)
7 · 25.0%
Hydrophobic aliphatic (A,V,I,L,M)
8 · 28.6%
Top residues
E621.4%K414.3%A310.7%D310.7%S310.7%T310.7%V310.7%N13.6%
Hydropathy & amphipathic windows
Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window
3-9
AAVDTSS
GRAVY 0.286
Most hydrophilic window
14-20
KDLKEKK
GRAVY -2.686
22 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.
Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

12 aa window
17-28
KEKKEVVEEAEN
μH 1.60 · charge -2.0
12 aa window
14-25
KDLKEKKEVVEE
μH 1.49 · charge -1.0
12 aa window
16-27
LKEKKEVVEEAE
μH 1.43 · charge -2.0
15 aa window
14-28
KDLKEKKEVVEEAEN
μH 1.41 · charge -2.0
12 aa window
15-26
DLKEKKEVVEEA
μH 1.30 · charge -2.0
Sequence-liability cues
Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

Asp isomerization motif
DT · pos 6
Asp-containing motifs can merit review for isomerization or related degradation pathways.
Alpha-helix amphipathic projection
Helical wheel · Edmundson projection
μH = 1.07100°/residue · 28 aa
μH1: S (Ser) · Polar · K-D -0.8S12: D (Asp) · Acidic − · K-D -3.5D23: A (Ala) · Hydrophobic · K-D 1.8A34: A (Ala) · Hydrophobic · K-D 1.8A45: V (Val) · Hydrophobic · K-D 4.2V56: D (Asp) · Acidic − · K-D -3.5D67: T (Thr) · Polar · K-D -0.7T78: S (Ser) · Polar · K-D -0.8S89: S (Ser) · Polar · K-D -0.8S910: E (Glu) · Acidic − · K-D -3.5E1011: I (Ile) · Hydrophobic · K-D 4.5I1112: T (Thr) · Polar · K-D -0.7T1213: T (Thr) · Polar · K-D -0.7T1314: K (Lys) · Basic + · K-D -3.9K1415: D (Asp) · Acidic − · K-D -3.5D1516: L (Leu) · Hydrophobic · K-D 3.8L1617: K (Lys) · Basic + · K-D -3.9K1718: E (Glu) · Acidic − · K-D -3.5E1819: K (Lys) · Basic + · K-D -3.9K1920: K (Lys) · Basic + · K-D -3.9K2021: E (Glu) · Acidic − · K-D -3.5E2122: V (Val) · Hydrophobic · K-D 4.2V2223: V (Val) · Hydrophobic · K-D 4.2V2324: E (Glu) · Acidic − · K-D -3.5E2425: E (Glu) · Acidic − · K-D -3.5E2526: A (Ala) · Hydrophobic · K-D 1.8A2627: E (Glu) · Acidic − · K-D -3.5E2728: N (Asn) · Polar · K-D -3.5N28
Hydrophobic moment1.07
Mean K-D hydropathy-1.03
Approx. net charge-5
Projection angle100° / residue
The pale sector marks the direction of the hydrophobic face inferred from μH. This is a projection assumption, not a measured fold.
HydrophobicAromaticPolarBasic +Acidic −Specialhydrophobic faceμH arrow → hydrophobic face

The projection assumes an α-helix conformation; a long μH arrow indicates an amphipathic helix, common in antimicrobial peptides.

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Sequence-derived

Computed from the standard parent-residue sequence; protein-origin metrics defined at any length.

Aliphatic index
69.64
Instability index
28.1

At or below 40 — predicted stable in vitro.

Boman index
3.08 kcal/mol

Above 2.48 — elevated potential protein-binding.

Molar extinction coefficient (280 nm)
0 M⁻¹·cm⁻¹

A280 (1 g/L) ≈ 0.00

Structure-derived descriptors are not shown because this identity has no resolved chemical structure (SMILES). This is a known coverage gap for disulfide-rich and unresolved peptidoforms, not a computation error.

03

Exposure / Absorption

4 records

What evidence describes systemic exposure or absorption?

Evidence records
4
Complete canonical measurements and observations attached to this domain.
Endpoint scope
3
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
3
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
1
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeTmaxCmaxAUC
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
3
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
1
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
0
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
AUC1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

95-267 μg*h/L

Eligible when experimental context matches

ELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC review corroboration · human · serum

Result: Interval measurement · Molecular form: not reported · Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Source: Primary reference linked

Reference
Cmax1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

30-80 μg/L

Eligible when experimental context matches

ELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC review corroboration · human · serum

Result: Interval measurement · Molecular form: not reported · Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Source: Primary reference linked

Reference
Tmax2 records · 1 matched-context · 1 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

0.67-2 h

2412-7200 seconds
Eligible when experimental context matches

ELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC review corroboration · human · serum

Result: Interval measurement · Molecular form: not reported · Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Source: Primary reference linked

Reference
2

~ 2 hours

~ 7200 seconds
Use only explicitly reported fields

Not specified

Result: Approximate quantitative measurement · Molecular form: not reported · Route: IM, SC · 13 · Thymalfasin · exact product name match · exact or normalized match · Source: Primary reference linked

Source record
04

Distribution / Barrier

1 records

What is known about distribution, binding, permeability, or barrier crossing?

Evidence records
1
Complete canonical measurements and observations attached to this domain.
Endpoint scope
1
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
1
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
0
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeVd
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
1
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
0
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
0
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Vd1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

30-40 L

Eligible when experimental context matches

ELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC review corroboration · human · serum

Result: Interval measurement · Molecular form: not reported · Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Source: Primary reference linked

Reference
Barrier and permeability assay context

PAMPA, Caco-2, MDCK/RRCK, and BBB findings are assay/model contexts under Distribution / Barrier. They should not be read as interchangeable measurements.

PAMPA
0

artificial membrane

Caco-2
0

cell monolayer

MDCK
0

cell monolayer

RRCK
0

cell monolayer

BBB
0

barrier evidence

05

Metabolic & Proteolytic Stability

1 records

How stable is the peptide in biological matrices or protease systems?

Evidence records
1
Complete canonical measurements and observations attached to this domain.
Endpoint scope
1
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
1
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
0
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeSerum/plasma stability
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
1
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
0
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
0
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Serum/plasma stability1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

127 ±11 minutes

7620 seconds
Eligible when experimental context matches

HPLC · Heparinized rabbit plasma

Result: Reported point value · Molecular form: ATLPF0040993 · Rabbit plasma proteases · in vitro · Source: Primary reference linked

Reference
06

Evidence landscape

6 records

Cross-domain evidence distribution and measurement-level detail; the domain modules above show evidence in context, and every row remains available for audit here.

Evidence landscape

A cross-domain view of evidence volume, scientifically permitted analysis use, and source traceability.

ADMET domain
Eligible when context matches
Interpret as reported
Supporting context only
Review before analysis
Exposure / Absorption
4 evidence records
3
1
0
0
Distribution / Barrier
1 evidence record
1
0
0
0
Metabolic & Proteolytic Stability
1 evidence record
1
0
0
0
Excretion / Persistence
0 evidence records
0
0
0
0
Toxicity / Safety
0 evidence records
0
0
0
0
Endpoint distribution

Top evidence-bearing endpoint questions.

Time To Max Concentration
2
Area Under Curve
1
Max Concentration
1
Serum Plasma Stability
1
Volume Of Distribution
1
Assay context

Broad context buckets, useful before comparing values.

In vivo / route
4
Clinical / product
1
Matrix / stability
1
Traceability

Reference-link availability for measurement-level audit.

Linked reference
6
Not linked
0
All evidence index

Every evidence record remains available for audit and drilldown. Counts describe evidence volume, not confidence.

#ADMET domainEndpointReported valueResult typeAnalysis useAssay / modelConditionReference
1
Metabolic & Proteolytic Stability
Stability
Serum Plasma Stability
127 ±11 minutes
7,620 seconds
Reported point valueEligible when experimental context matchesHPLC · Heparinized rabbit plasmaProtease: Rabbit plasma proteases · in vitro
Reference
Primary reference linked
2
Exposure / Absorption
Exposure
Time To Max Concentration
~ 2 hours
~ 7,200 seconds
Approximate quantitative measurementUse only explicitly reported fieldsNot specifiedRoute: IM, SC
Source record
Primary reference linked
3
Exposure / Absorption
Exposure
Max Concentration
30-80 μg/L
Interval measurementEligible when experimental context matchesELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC re...Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Human healthy-volunteer crossover PK study comparing three subcutaneous thymosin alpha1 formulations. The public...
Reference
Primary reference linked
4
Exposure / Absorption
Exposure
Area Under Curve
95-267 μg*h/L
Interval measurementEligible when experimental context matchesELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC re...Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Human healthy-volunteer crossover PK study comparing three subcutaneous thymosin alpha1 formulations. The public...
Reference
Primary reference linked
5
Exposure / Absorption
Exposure
Time To Max Concentration
0.67-2 h
2,412-7,200 seconds
Interval measurementEligible when experimental context matchesELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC re...Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Human healthy-volunteer crossover PK study comparing three subcutaneous thymosin alpha1 formulations. The public...
Reference
Primary reference linked
6
Distribution / Barrier
Distribution
Volume Of Distribution
30-40 L
Interval measurementEligible when experimental context matchesELISA serum concentration assay; model-independent PK analysis; manual extraction from PubMed abstract with FDA PCAC re...Route: subcutaneous · Dose/window: single-dose and 5-day multiple-dose PK · Human healthy-volunteer crossover PK study comparing three subcutaneous thymosin alpha1 formulations. The public...
Reference
Primary reference linked
1–6 / 6
07

Product context

1 products

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

·
Summary1 linked product
Linked products
1
Label context
None
Clinical trials
35
Safety label cues
None
Linked products1 shown

Thymalfasin

Tα1 (Thymosin α1)Thymosin α1Tα1Tα1 (Thymosin α1)
Peptide-product match
Reviewed peptide match
Route / product class
Subcutaneous
Clinical context
35 trial records · 10 exact intervention matches · latest 2026-03-19
Label safety context
No label safety cue linked
View product
08

Identity & reference map

6 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

·
Summary3 reference groups
Identity type
canonical sequence
Reported notation
1
Reference groups
3
Measurements
6
ATL peptide ID
ATLPC0003634
Identity concordance
Identity concordance
Exact reported notation

Reported sequence string matches the current peptide notation.

0 / 6
Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 6
Different notation

Reported notation does not resolve to the current display sequence.

1 / 6
Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

5 / 6
Reported sequence notation
Different1 reference
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Current identity
SDAAVDTSSEITTKDLKEKKEVVEEAEN
Reported names
No distinct human-readable aliases are exposed.
Reference map3 reference groups
Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

ReferenceSupportsReported identityRecords
Reference
Open
DistributionExposure
Area Under Curve, Max Concentration, Time To Max Concentration, Volume Of Distribution
No reported alias
4 identity
4 evidence
Reference
Open
Stability
Serum Plasma Stability
No reported alias
1 identity
1 evidence
Source record
Open
Exposure
Time To Max Concentration
No reported alias
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAENdifferent
1 identity
1 evidence
09

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

·
Record scopePublic release
ATL peptide ID
ATLPC0003634
Identity type
canonical sequence
ADMET endpoints
5
Evidence records
6
Reference groups
3
Release view
Public release
Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements
Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint
GET /api/v1/peptides/ATLPC0003634
open
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0003634' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'
ADMETatlas
peptide evidence atlas

ADMETatlas is an open, curated atlas of ADMET evidence for therapeutic peptides — spanning developability, membrane permeability and blood–brain-barrier transport, immune-recognition context, and approved-product context. Every measurement stays linked to its original source, with stable identifiers and transparent curation, so results can be traced, cited, and reproduced.

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