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Peptide·plain sequence-like

ATLPC0008097

ATLPC0008097

HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR

Compare in workbenchDownload releaseAPI JSON
  • Length
    30 aa
  • Monoisotopic mass
    3296.6 Da
  • Net charge @ pH 7.4
    -0.90
  • Isoelectric point
    5.62
  • GRAVY
    -0.230
On this page
  • 01 Sequence & molecular identity
  • 02 Physicochemical profile
  • 03 Metabolic & Proteolytic Stability
  • 04 Excretion / Persistence
  • 05 Evidence landscape
  • 06 Product context
  • 07 Identity & reference map
  • 08 Data access & reproducibility
Coveragecounts only · not riskATLPC0008097
  • Measurements
    91
  • Endpoints
    3
  • Domains
    2/5
  • Products
    —
  • 35 stability measurements
  • 56 clearance measurements
  • No immunogenicity context
  • 1 liability motif
Jump to domain

Open the matching evidence section below

All evidence index · 91
Exposure / Absorption
No evidence
Distribution / Barrier
No evidence
Metabolic & Proteolytic Stability
35 measurements
Excretion / Persistence
56 measurements
Toxicity / Safety
No evidence
01

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

·
Identity summaryCanonical sequence only
Identity status
Canonical sequence only
Residues
30
Peptidoform features
0
Documented molecular forms
1
Representations
2
Documented molecular forms1 form linked to this peptide identity
FormTopologyModificationsConnectionsRepresentationsMeasurements
ATLPF0008884———Notation only35
Residue view
Residue display
30 residues
H1A2E3G4T5F6T7S8D9V10S11S12Y13L14E15G16Q17A18A19K20E21F22I23A24W25L26V27K28G29R30
Secondary structureα-helix (H)β-strand (E)coil (C)
Side-chain classNonpolarPolarBasic (+)Acidic (−)Modified

Soft tints mark standard side-chain classes for scanning. Primary emphasis is reserved for reported modifications, termini, secondary-structure tracks, and topology links.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

·
Chemical representationsequence / HELM only
Representation class

How the current release can interpret this identity chemically.

plain sequence-like
Parent-residue sequence

Residue string used for positional interpretation when available.

HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR
HELM

Polymer notation for modified peptide representation when available.

Not available
SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available
No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure references1 reference
3D coordinates·Exact PDB matchexperimental
Exact PDB match·reference selected·length 30 aa·confidence experimental
LinkMethodConfidenceMatch
OpenExperimental coordinate entryexperimental30 aa
Covalent topology & modificationsnone
Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

02

Physicochemical profile

4 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

·
Core descriptors30 aa · pI 5.6 · GRAVY -0.23
Length
30 aa
Monoisotopic mass
3296.65 Da
Average mass
3298.66 Da
Net charge at pH 7.4
-0.90
Estimated pI
5.62
GRAVY
-0.230
KD-positive residues
36.7%
Aromatic residues
13.3%
Developability interpretation
Ionization context
pH 7.4 separated from pI
Hydrophobicity balance
Leans hydrophilic
Amphipathic moment (μH)
0.08
Computation boundary
Standard-sequence only
Charge & residue composition
pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2
4.94
pH 5
0.42
pH 6
-0.19
pH 7.4
-0.95
pH 9
-1.82
pH 12
-5.11
Residue-class composition

Grouped composition is often more interpretable than a long amino-acid list.

Acidic (D,E)
4 · 13.3%
Basic (K,R,H)
4 · 13.3%
Polar uncharged (N,Q,S,T)
6 · 20.0%
Hydrophobic aliphatic (A,V,I,L,M)
9 · 30.0%
Aromatic (F,W,Y)
4 · 13.3%
Conformational / sulfur (G,P,C)
3 · 10.0%
Top residues
A413.3%E310.0%G310.0%S310.0%L26.7%K26.7%F26.7%T26.7%
Hydropathy & amphipathic windows
Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window
21-27
EFIAWLV
GRAVY 1.814
Most hydrophilic window
15-21
EGQAAKE
GRAVY -1.600
24 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.
Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

12 aa window
17-28
QAAKEFIAWLVK
μH 1.74 · charge 1.0
12 aa window
18-29
AAKEFIAWLVKG
μH 1.46 · charge 1.0
12 aa window
16-27
GQAAKEFIAWLV
μH 1.40 · charge 0.0
15 aa window
15-29
EGQAAKEFIAWLVKG
μH 1.20 · charge 0.0
12 aa window
5-16
TFTSDVSSYLEG
μH 1.18 · charge -2.0
Sequence-liability cues
Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

Oxidation-sensitive residues
W · pos 25
Met, Trp, and Cys residues can merit formulation review for oxidation or covalent-state sensitivity.
Alpha-helix amphipathic projection
Helical wheel · Edmundson projection
μH = 0.08100°/residue · 30 aa
μH1: H (His) · Basic + · K-D -3.2H12: A (Ala) · Hydrophobic · K-D 1.8A23: E (Glu) · Acidic − · K-D -3.5E34: G (Gly) · Special · K-D -0.4G45: T (Thr) · Polar · K-D -0.7T56: F (Phe) · Aromatic · K-D 2.8F67: T (Thr) · Polar · K-D -0.7T78: S (Ser) · Polar · K-D -0.8S89: D (Asp) · Acidic − · K-D -3.5D910: V (Val) · Hydrophobic · K-D 4.2V1011: S (Ser) · Polar · K-D -0.8S1112: S (Ser) · Polar · K-D -0.8S1213: Y (Tyr) · Aromatic · K-D -1.3Y1314: L (Leu) · Hydrophobic · K-D 3.8L1415: E (Glu) · Acidic − · K-D -3.5E1516: G (Gly) · Special · K-D -0.4G1617: Q (Gln) · Polar · K-D -3.5Q1718: A (Ala) · Hydrophobic · K-D 1.8A1819: A (Ala) · Hydrophobic · K-D 1.8A1920: K (Lys) · Basic + · K-D -3.9K2021: E (Glu) · Acidic − · K-D -3.5E2122: F (Phe) · Aromatic · K-D 2.8F2223: I (Ile) · Hydrophobic · K-D 4.5I2324: A (Ala) · Hydrophobic · K-D 1.8A2425: W (Trp) · Aromatic · K-D -0.9W2526: L (Leu) · Hydrophobic · K-D 3.8L2627: V (Val) · Hydrophobic · K-D 4.2V2728: K (Lys) · Basic + · K-D -3.9K2829: G (Gly) · Special · K-D -0.4G2930: R (Arg) · Basic + · K-D -4.5R30
Hydrophobic moment0.08
Mean K-D hydropathy-0.23
Approx. net charge-1
Projection angle100° / residue
The pale sector marks the direction of the hydrophobic face inferred from μH. This is a projection assumption, not a measured fold.
HydrophobicAromaticPolarBasic +Acidic −Specialhydrophobic faceμH arrow → hydrophobic face

The projection assumes an α-helix conformation; a long μH arrow indicates an amphipathic helix, common in antimicrobial peptides.

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Sequence-derived

Computed from the standard parent-residue sequence; protein-origin metrics defined at any length.

Aliphatic index
71.67
Instability index
17.7

At or below 40 — predicted stable in vitro.

Boman index
1.32 kcal/mol
Molar extinction coefficient (280 nm)
6,990 M⁻¹·cm⁻¹

A280 (1 g/L) ≈ 2.12

Structure-derived descriptors are not shown because this identity has no resolved chemical structure (SMILES). This is a known coverage gap for disulfide-rich and unresolved peptidoforms, not a computation error.

03

Metabolic & Proteolytic Stability

35 records

How stable is the peptide in biological matrices or protease systems?

Evidence records
35
Complete canonical measurements and observations attached to this domain.
Endpoint scope
2
Formal ADMET endpoints represented for this peptide.
Matched-context in preview
5
Quantitative results that may be analysed only with scientifically compatible records.
Reported results in preview
0
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeSerum/plasma stabilityProtease stability
Loading 35 Metabolic & Proteolytic Stability records…
04

Excretion / Persistence

56 records

What evidence describes clearance or persistence?

Evidence records
56
Complete canonical measurements and observations attached to this domain.
Endpoint scope
1
Formal ADMET endpoints represented for this peptide.
Matched-context in preview
13
Quantitative results that may be analysed only with scientifically compatible records.
Reported results in preview
2
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeHalf Life
Loading 56 Excretion / Persistence records…
05

Evidence landscape

91 records

Cross-domain evidence distribution and measurement-level detail. 20 of 91 evidence records are included in the profile preview; the full index is loaded below.

Loading 91 measurements…
06

Product context

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

No product association in this release

This peptide is currently interpreted from sequence, structure, physicochemical, and ADMET evidence only.

Browse products
07

Identity & reference map

91 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

·
Summary22 reference groups
Identity type
canonical sequence
Reported notation
0
Reference groups
22
Measurements
91
ATL peptide ID
ATLPC0008097
Identity concordance
Identity concordance
Exact reported notation

Reported sequence string matches the current peptide notation.

0 / 91
Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 91
Different notation

Reported notation does not resolve to the current display sequence.

0 / 91
Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

91 / 91
Reported sequence notation

No source-specific sequence notation has been captured in the current identity references.

Current identity
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR
Reported names
No distinct human-readable aliases are exposed.
Reference map22 reference groups
Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

ReferenceSupportsReported identityRecords
Reference
Open
Persistence
Half Life
No reported alias
23 identity
8 evidence
Reference
Open
Stability
Protease Stability
No reported alias
12 identity
2 evidence
Reference
Open
Persistence
Half Life
No reported alias
9 identity
1 evidence
Reference
Open
Stability
Serum Plasma Stability
No reported alias
6 identity
2 evidence
Reference
Open
Identity only
No reported alias
8 identity
0 evidence
Reference
Open
Persistence
Half Life
No reported alias
4 identity
1 evidence
Reference
Open
Identity only
No reported alias
4 identity
0 evidence
Reference
Open
Persistence
Half Life
No reported alias
3 identity
1 evidence
Reference
Open
Identity only
No reported alias
4 identity
0 evidence
Reference
Open
Stability
Serum Plasma Stability
No reported alias
2 identity
1 evidence
1–10 / 22
08

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

·
Record scopePublic release
ATL peptide ID
ATLPC0008097
Identity type
canonical sequence
ADMET endpoints
3
Evidence records
91
Reference groups
22
Release view
Public release
Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements
Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint
GET /api/v1/peptides/ATLPC0008097
open
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0008097' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'
ADMETatlas
peptide evidence atlas

ADMETatlas is an open, curated atlas of ADMET evidence for therapeutic peptides — spanning developability, membrane permeability and blood–brain-barrier transport, immune-recognition context, and approved-product context. Every measurement stays linked to its original source, with stable identifiers and transparent curation, so results can be traced, cited, and reproduced.

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