Peptide·plain sequence-like

Carbetocin

ATLPC0011879

Routes

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Coveragecounts only · not riskATLPC0011879

Measurements
12
Endpoints
6
Domains
3/5
Products
1

No matrix stability evidence
2 clearance measurements
Product-level review pending
No sequence liability cues

Jump to domain

Open the matching evidence section below

All evidence index · 12

Exposure / Absorption

9 measurements

Distribution / Barrier

1 measurement

Metabolic & Proteolytic Stability

No evidence

Excretion / Persistence

2 measurements

Toxicity / Safety

No evidence

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

No reviewed sequence representation available

This peptide currently has identity-level evidence, but no reviewed sequence, HELM, or SMILES representation for residue-level interpretation.

Structure & chemistry

Chemical representationnone

Representation class

How the current release can interpret this identity chemically.

plain sequence-like

Parent-residue sequence

Residue string used for positional interpretation when available.

Not available

HELM

Polymer notation for modified peptide representation when available.

Not available

SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available

No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure referencesnone attached

3D structure not available

A 3D structure isn't available for this peptide in the current release. Chemistry and topology fields remain available when represented by sequence, HELM, or SMILES.

Covalent topology & modificationsnone

Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

Physicochemical profile

6 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

Physicochemical descriptors unavailable

These descriptors require a standard parent-residue sequence. The module remains visible so modified or unresolved identities are not forced into unreliable computed values.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Structure-derived (developability)

Computed from the representative peptidoform's chemical structure. Rule-of-5 / beyond-Ro5 framing per Lipinski/Doak.

Topological polar surface area

362.5 Å²

Computed logP (Crippen)

-2.50

Computed logP — distinct from the measured logD endpoint.

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Rule-of-5 / beyond-Ro5 flags

Beyond bRo5

3 Ro5 violations · MW 988.18 Da

Exposure / Absorption

9 records

What evidence describes systemic exposure or absorption?

Evidence records

Complete canonical measurements and observations attached to this domain.

Endpoint scope

Formal ADMET endpoints represented for this peptide.

Matched-context analysis

Quantitative results that may be analysed only with scientifically compatible records.

Reported-result review

Qualitative, narrative, or review-first results interpreted in their source context.

Endpoints in scopeTmax Bioavailability Cmax AUC

Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis

Quantitative results whose endpoint and context must still be matched before analysis.

Interpret as reported

Qualitative, narrative, or review-first findings preserved in source context.

Supporting context only

Reference, label, clinical, or supporting context for interpretation.

Review before analysis

Records whose present structure does not establish a safe analysis role.

Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

Bioavailability3 records · 2 matched-context · 1 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	77 %	Eligible when experimental context matches	Canadian Product Monograph 10.3 pharmacokinetics manual extraction · human · plasma	Result: Reported point value · Molecular form: ATLPF0008023 · Route: intramuscular · Source: Primary reference linked	Reference
2	~ 80 %	Eligible when experimental context matches	TGA Product Information 5.2 pharmacokinetic properties manual extraction · human · plasma	Result: Approximate quantitative measurement · Molecular form: ATLPF0008023 · Route: intramuscular · Source: Primary reference linked	Reference
3	80 %	Use only explicitly reported fields	Not specified	Result: Reported point value · Molecular form: not reported · Route: IV, IM · 47 · Carbetocin · exact product name match · exact or normalized match · Source: Primary reference linked	Source record

AUC2 records · 2 matched-context · 0 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	2.147 ng*h/mL	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Result: Reported point value · Molecular form: ATLPF0008023 · Route: intramuscular · Dose/window: 100 mcg IM carbetocin; N=20; AUC0-inf · Source: Primary reference linked	Reference
2	2.762 ng*h/mL	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Result: Reported point value · Molecular form: ATLPF0008023 · Route: intravenous · Dose/window: 100 mcg IV carbetocin; N=19; AUC0-inf · Source: Primary reference linked	Reference

Cmax2 records · 2 matched-context · 0 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	1.03 ng/mL	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Result: Reported point value · Molecular form: ATLPF0008023 · Route: intramuscular · Dose/window: 100 mcg IM carbetocin; N=20 · Source: Primary reference linked	Reference
2	7.232 ng/mL	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Result: Reported point value · Molecular form: ATLPF0008023 · Route: intravenous · Dose/window: 100 mcg IV carbetocin; N=19 · Time: 5 minutes postdose · Source: Primary reference linked	Reference

Tmax2 records · 2 matched-context · 0 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	0.25-0.75 h 900-2700 seconds	Eligible when experimental context matches	Canadian Product Monograph 10.3 pharmacokinetics manual extraction · human · plasma	Result: Interval measurement · Molecular form: ATLPF0008023 · Route: intramuscular · 20 · Source: Primary reference linked	Reference
2	20-30 minutes 1200-1800 seconds	Eligible when experimental context matches	TGA Product Information 5.2 pharmacokinetic properties manual extraction · human · plasma	Result: Interval measurement · Molecular form: ATLPF0008023 · Route: intramuscular · Source: Primary reference linked	Reference

Distribution / Barrier

1 records

What is known about distribution, binding, permeability, or barrier crossing?

Evidence records

Complete canonical measurements and observations attached to this domain.

Endpoint scope

Formal ADMET endpoints represented for this peptide.

Matched-context analysis

Quantitative results that may be analysed only with scientifically compatible records.

Reported-result review

Qualitative, narrative, or review-first results interpreted in their source context.

Endpoints in scopeVd

Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis

Quantitative results whose endpoint and context must still be matched before analysis.

Interpret as reported

Qualitative, narrative, or review-first findings preserved in source context.

Supporting context only

Reference, label, clinical, or supporting context for interpretation.

Review before analysis

Records whose present structure does not establish a safe analysis role.

Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

Vd1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	22 L	Eligible when experimental context matches	Canadian Product Monograph 10.3 pharmacokinetics manual extraction · human · plasma	Result: Reported point value · Molecular form: ATLPF0008023 · Source: Primary reference linked	Reference

Barrier and permeability assay context

PAMPA, Caco-2, MDCK/RRCK, and BBB findings are assay/model contexts under Distribution / Barrier. They should not be read as interchangeable measurements.

PAMPA

artificial membrane

Caco-2

cell monolayer

MDCK

cell monolayer

RRCK

cell monolayer

BBB

barrier evidence

Excretion / Persistence

2 records

What evidence describes clearance or persistence?

Evidence records

Complete canonical measurements and observations attached to this domain.

Endpoint scope

Formal ADMET endpoints represented for this peptide.

Matched-context analysis

Quantitative results that may be analysed only with scientifically compatible records.

Reported-result review

Qualitative, narrative, or review-first results interpreted in their source context.

Endpoints in scopeClearance

Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis

Quantitative results whose endpoint and context must still be matched before analysis.

Interpret as reported

Qualitative, narrative, or review-first findings preserved in source context.

Supporting context only

Reference, label, clinical, or supporting context for interpretation.

Review before analysis

Records whose present structure does not establish a safe analysis role.

Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

Clearance2 records · 2 matched-context · 0 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	22 mL/min/kg	Eligible when experimental context matches	Clearance in Sprague-Dawley rat at 0.2 mg/kg, iv administered in cassette mode as bolus dose · rat	Result: Reported point value · Molecular form: not reported · Route: iv · clearance · CL· Clearance in Sprague-Dawley rat at 0.2 mg/kg, iv administered in cassette... · Source: Primary reference linked	Reference
2	0.55-0.6 L/min	Eligible when experimental context matches	TGA Product Information 5.2 pharmacokinetic properties manual extraction · human · plasma	Result: Interval measurement · Molecular form: ATLPF0008023 · Route: intravenous · Source: Primary reference linked	Reference

Evidence landscape

12 records

Cross-domain evidence distribution and measurement-level detail; the domain modules above show evidence in context, and every row remains available for audit here.

Evidence landscape

A cross-domain view of evidence volume, scientifically permitted analysis use, and source traceability.

ADMET domain

Eligible when context matches

Interpret as reported

Supporting context only

Review before analysis

Exposure / Absorption

9 evidence records

Distribution / Barrier

1 evidence record

Metabolic & Proteolytic Stability

0 evidence records

Excretion / Persistence

2 evidence records

Toxicity / Safety

0 evidence records

Endpoint distribution

Top evidence-bearing endpoint questions.

Bioavailability

Area Under Curve

Clearance

Max Concentration

Time To Max Concentration

Volume Of Distribution

Assay context

Broad context buckets, useful before comparing values.

In vivo / route

Clinical / product

Traceability

Reference-link availability for measurement-level audit.

Linked reference

Not linked

All evidence index

Every evidence record remains available for audit and drilldown. Counts describe evidence volume, not confidence.

DomainAnalysis useReferenceSpeciesRoute

#	ADMET domain	Endpoint	Reported value	Result type	Analysis use	Assay / model	Condition	Reference
1	Exposure / Absorption Exposure	Time To Max Concentration	20-30 minutes 1,200-1,800 seconds	Interval measurement	Eligible when experimental context matches	TGA Product Information 5.2 pharmacokinetic properties manual extraction · human · plasma	Route: intramuscular · Evaluated in 25 non-pregnant healthy women after 400 or 800 microgram IV or IM carbetocin in Study CLN 6.3.1.	Reference Primary reference linked
2	Exposure / Absorption Exposure	Bioavailability	~ 80 %	Approximate quantitative measurement	Eligible when experimental context matches	TGA Product Information 5.2 pharmacokinetic properties manual extraction · human · plasma	Route: intramuscular · Evaluated in 25 non-pregnant healthy women after 400 or 800 microgram IV or IM carbetocin in Study CLN 6.3.1.	Reference Primary reference linked
3	Excretion / Persistence Persistence	Clearance	0.55-0.6 L/min	Interval measurement	Eligible when experimental context matches	TGA Product Information 5.2 pharmacokinetic properties manual extraction · human · plasma	Route: intravenous · Clearance reported after a 400 microgram IV carbetocin dose · similar values were obtained after the 800 microgram dose.	Reference Primary reference linked
4	Exposure / Absorption Exposure	Time To Max Concentration	0.25-0.75 h 900-2,700 seconds	Interval measurement	Eligible when experimental context matches	Canadian Product Monograph 10.3 pharmacokinetics manual extraction · human · plasma	Route: intramuscular · Heat-stable carbetocin formulation · pharmacokinetic analysis set	Reference Primary reference linked
5	Exposure / Absorption Exposure	Bioavailability	77 %	Reported point value	Eligible when experimental context matches	Canadian Product Monograph 10.3 pharmacokinetics manual extraction · human · plasma	Route: intramuscular · Healthy female subjects · heat-stable carbetocin formulation.	Reference Primary reference linked
6	Exposure / Absorption Exposure	Max Concentration	7.232 ng/mL	Reported point value	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Route: intravenous · Time: 5 minutes postdose · Dose/window: 100 mcg IV carbetocin; N=19 · Heat-stable carbetocin formulation · pharmacokinetic analysis set	Reference Primary reference linked
7	Exposure / Absorption Exposure	Max Concentration	1.03 ng/mL	Reported point value	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Route: intramuscular · Dose/window: 100 mcg IM carbetocin; N=20 · Heat-stable carbetocin formulation · pharmacokinetic analysis set	Reference Primary reference linked
8	Exposure / Absorption Exposure	Area Under Curve	2.762 ng*h/mL	Reported point value	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Route: intravenous · Dose/window: 100 mcg IV carbetocin; N=19; AUC0-inf · Heat-stable carbetocin formulation · pharmacokinetic analysis set	Reference Primary reference linked
9	Exposure / Absorption Exposure	Area Under Curve	2.147 ng*h/mL	Reported point value	Eligible when experimental context matches	Canadian Product Monograph Table 6 pharmacokinetics manual extraction · human · plasma	Route: intramuscular · Dose/window: 100 mcg IM carbetocin; N=20; AUC0-inf · Heat-stable carbetocin formulation · pharmacokinetic analysis set	Reference Primary reference linked
10	Distribution / Barrier Distribution	Volume Of Distribution	22 L	Reported point value	Eligible when experimental context matches	Canadian Product Monograph 10.3 pharmacokinetics manual extraction · human · plasma	Vz, volume of distribution at pseudo-equilibrium.	Reference Primary reference linked

1–10 / 12

Product context

1 products

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

Summary1 linked product

Linked products: 1
Label context: None
Clinical trials: 25
Safety label cues: None

Linked products1 shown

Carbetocin

Peptide-product match

Reviewed peptide match

Route / product class

Not resolved in this release

Clinical context

25 trial records · 18 exact intervention matches · 2 with results · latest 2026-04-06

Label safety context

No label safety cue linked

View product

Identity & reference map

12 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

Summary4 reference groups

Identity type: identity record
Reported notation: 1
Reference groups: 4
Measurements: 12
ATL peptide ID: ATLPC0011879

Identity concordance

Exact reported notation

Reported sequence string matches the current peptide notation.

0 / 12

Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 12

Different notation

Reported notation does not resolve to the current display sequence.

1 / 12

Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

11 / 12

Reported sequence notation

Different1 reference

XXIQNCPLG-NH2

Current identity

No sequence representation

Reported names

No distinct human-readable aliases are exposed.

Reference map4 reference groups

Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

Reference	Supports	Reported identity	Records
Reference Open	DistributionExposure Area Under Curve, Bioavailability, Max Concentration, Time To Max Concentration +1 more	No reported alias	7 identity 7 evidence
Reference Open	ExposurePersistence Bioavailability, Clearance, Time To Max Concentration	No reported alias	3 identity 3 evidence
Source record Open	Exposure Bioavailability	No reported alias XXIQNCPLG-NH2different	1 identity 1 evidence
Reference Open	Persistence Clearance	No reported alias	1 identity 1 evidence

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

Record scopePublic release

ATL peptide ID: ATLPC0011879
Identity type: identity record
ADMET endpoints: 6
Evidence records: 12
Reference groups: 4
Release view: Public release

Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements

Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint

GET /api/v1/peptides/ATLPC0011879

open

curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0011879' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'

Value

Analysis use

Assay / model

Result context

Reference

77 %

Eligible when experimental context matches

Canadian Product Monograph 10.3 pharmacokinetics manual extraction · human · plasma

Result: Reported point value · Molecular form: ATLPF0008023 · Route: intramuscular · Source: Primary reference linked