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Peptide·plain sequence-like

ATLPC0012326

ATLPC0012326

FNAPFDVGIKLSGAQYQQHGRAL

Compare in workbenchDownload releaseAPI JSON
  • Length
    23 aa
  • Monoisotopic mass
    2516.3 Da
  • Net charge @ pH 7.4
    1.10
  • Isoelectric point
    9.30
  • GRAVY
    -0.291
On this page
  • 01 Sequence & molecular identity
  • 02 Physicochemical profile
  • 03 Metabolic & Proteolytic Stability
  • 04 Excretion / Persistence
  • 05 Evidence landscape
  • 06 Product context
  • 07 Identity & reference map
  • 08 Data access & reproducibility
Coveragecounts only · not riskATLPC0012326
  • Measurements
    21
  • Endpoints
    3
  • Domains
    2/5
  • Products
    —
  • 3 stability measurements
  • 18 clearance measurements
  • No immunogenicity context
  • No sequence liability cues
Jump to domain

Open the matching evidence section below

All evidence index · 21
Exposure / Absorption
No evidence
Distribution / Barrier
No evidence
Metabolic & Proteolytic Stability
3 measurements
Excretion / Persistence
18 measurements
Toxicity / Safety
No evidence
01

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

·
Identity summaryCanonical sequence only
Identity status
Canonical sequence only
Residues
23
Peptidoform features
0
Documented molecular forms
1
Representations
2
Documented molecular forms1 form linked to this peptide identity
FormTopologyModificationsConnectionsRepresentationsMeasurements
ATLPF0013475—1—Notation only21
Residue view
Residue display
23 residues
F1N2A3P4F5D6V7G8I9K10L11S12G13A14Q15Y16Q17Q18H19G20R21A22L23
Secondary structureα-helix (H)β-strand (E)coil (C)
Side-chain classNonpolarPolarBasic (+)Acidic (−)Modified

Soft tints mark standard side-chain classes for scanning. Primary emphasis is reserved for reported modifications, termini, secondary-structure tracks, and topology links.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

·
Chemical representationsequence / HELM only
Representation class

How the current release can interpret this identity chemically.

plain sequence-like
Parent-residue sequence

Residue string used for positional interpretation when available.

FNAPFDVGIKLSGAQYQQHGRAL
HELM

Polymer notation for modified peptide representation when available.

Not available
SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available
No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure references2 references
Structure reference·
3D coordinates·Exact PDB matchexperimental
Exact PDB match·reference selected·length 23 aa·confidence experimental
LinkMethodConfidenceMatch
OpenExperimental coordinate entryexperimental23 aa
OpenExperimental coordinate entryexperimental23 aa
Covalent topology & modificationsnone
Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

02

Physicochemical profile

4 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

·
Core descriptors23 aa · pI 9.3 · GRAVY -0.29
Length
23 aa
Monoisotopic mass
2516.29 Da
Average mass
2517.83 Da
Net charge at pH 7.4
1.10
Estimated pI
9.30
GRAVY
-0.291
KD-positive residues
39.1%
Aromatic residues
13.0%
Developability interpretation
Ionization context
pH 7.4 separated from pI
Hydrophobicity balance
Leans hydrophilic
Amphipathic moment (μH)
0.54
Computation boundary
Standard-sequence only
Charge & residue composition
pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2
3.96
pH 5
2.08
pH 6
1.77
pH 7.4
1.05
pH 9
0.20
pH 12
-2.17
Residue-class composition

Grouped composition is often more interpretable than a long amino-acid list.

Acidic (D,E)
1 · 4.3%
Basic (K,R,H)
3 · 13.0%
Polar uncharged (N,Q,S,T)
5 · 21.7%
Hydrophobic aliphatic (A,V,I,L,M)
7 · 30.4%
Aromatic (F,W,Y)
3 · 13.0%
Conformational / sulfur (G,P,C)
4 · 17.4%
Top residues
A313.0%Q313.0%G313.0%L28.7%F28.7%R14.3%N14.3%D14.3%
Hydropathy & amphipathic windows
Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window
3-9
APFDVGI
GRAVY 1.114
Most hydrophilic window
15-21
QYQQHGR
GRAVY -2.843
17 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.
Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

12 aa window
1-12
FNAPFDVGIKLS
μH 0.83 · charge 0.0
12 aa window
2-13
NAPFDVGIKLSG
μH 0.70 · charge 0.0
15 aa window
9-23
IKLSGAQYQQHGRAL
μH 0.66 · charge 2.1
12 aa window
6-17
DVGIKLSGAQYQ
μH 0.65 · charge 0.0
18 aa window
6-23
DVGIKLSGAQYQQHGRAL
μH 0.51 · charge 1.1
Sequence-liability cues
Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

No conservative sequence-liability motifs from the current rule set are present.
Alpha-helix amphipathic projection
Helical wheel · Edmundson projection
μH = 0.54100°/residue · 23 aa
μH1: F (Phe) · Aromatic · K-D 2.8F12: N (Asn) · Polar · K-D -3.5N23: A (Ala) · Hydrophobic · K-D 1.8A34: P (Pro) · Special · K-D -1.6P45: F (Phe) · Aromatic · K-D 2.8F56: D (Asp) · Acidic − · K-D -3.5D67: V (Val) · Hydrophobic · K-D 4.2V78: G (Gly) · Special · K-D -0.4G89: I (Ile) · Hydrophobic · K-D 4.5I910: K (Lys) · Basic + · K-D -3.9K1011: L (Leu) · Hydrophobic · K-D 3.8L1112: S (Ser) · Polar · K-D -0.8S1213: G (Gly) · Special · K-D -0.4G1314: A (Ala) · Hydrophobic · K-D 1.8A1415: Q (Gln) · Polar · K-D -3.5Q1516: Y (Tyr) · Aromatic · K-D -1.3Y1617: Q (Gln) · Polar · K-D -3.5Q1718: Q (Gln) · Polar · K-D -3.5Q1819: H (His) · Basic + · K-D -3.2H1920: G (Gly) · Special · K-D -0.4G2021: R (Arg) · Basic + · K-D -4.5R2122: A (Ala) · Hydrophobic · K-D 1.8A2223: L (Leu) · Hydrophobic · K-D 3.8L23
Hydrophobic moment0.54
Mean K-D hydropathy-0.29
Approx. net charge+1
Projection angle100° / residue
The pale sector marks the direction of the hydrophobic face inferred from μH. This is a projection assumption, not a measured fold.
HydrophobicAromaticPolarBasic +Acidic −Specialhydrophobic faceμH arrow → hydrophobic face

The projection assumes an α-helix conformation; a long μH arrow indicates an amphipathic helix, common in antimicrobial peptides.

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Sequence-derived

Computed from the standard parent-residue sequence; protein-origin metrics defined at any length.

Aliphatic index
76.52
Instability index
13.8

At or below 40 — predicted stable in vitro.

Boman index
1.20 kcal/mol
Molar extinction coefficient (280 nm)
1,490 M⁻¹·cm⁻¹

A280 (1 g/L) ≈ 0.59

Structure-derived descriptors are not shown because this identity has no resolved chemical structure (SMILES). This is a known coverage gap for disulfide-rich and unresolved peptidoforms, not a computation error.

03

Metabolic & Proteolytic Stability

3 records

How stable is the peptide in biological matrices or protease systems?

Evidence records
3
Complete canonical measurements and observations attached to this domain.
Endpoint scope
2
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
2
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
1
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeProtease stabilitySerum/plasma stability
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
2
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
1
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
0
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Serum/plasma stability1 record · 0 matched-context · 1 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

2532 seconds

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse plasma

Result: Reported point value · Molecular form: ATLPF0013475 · Dose/window: 90 μg · Proteases from mouse plasma · in vitro · Source: Primary reference linked

Reference
Protease stability2 records · 2 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

38.5 minutes

2310 seconds
Eligible when experimental context matches

HPLC · Membrane brain Homogenate + Soybean trypsin inhibitor

Result: Reported point value · Molecular form: ATLPF0013475 · Dose/window: 90 μg · Proteases from Membrane brain Homogenate · in vitro · Source: Primary reference linked

Reference
2

20.5 minutes

1230 seconds
Eligible when experimental context matches

HPLC · mouse · Crude brain homogenate of mouse + Soybean trypsin inhibitor

Result: Reported point value · Molecular form: ATLPF0013475 · Dose/window: 90 μg · Proteases from Crude brain homogenate of mouse · in vitro · Source: Primary reference linked

Reference
04

Excretion / Persistence

18 records

What evidence describes clearance or persistence?

Evidence records
18
Complete canonical measurements and observations attached to this domain.
Endpoint scope
1
Formal ADMET endpoints represented for this peptide.
Matched-context in preview
13
Quantitative results that may be analysed only with scientifically compatible records.
Reported results in preview
3
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeHalf Life
Loading 18 Excretion / Persistence records…
05

Evidence landscape

21 records

Cross-domain evidence distribution and measurement-level detail. 20 of 21 evidence records are included in the profile preview; the full index is loaded below.

Loading 21 measurements…
06

Product context

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

No product association in this release

This peptide is currently interpreted from sequence, structure, physicochemical, and ADMET evidence only.

Browse products
07

Identity & reference map

21 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

·
Summary3 reference groups
Identity type
canonical sequence
Reported notation
0
Reference groups
3
Measurements
21
ATL peptide ID
ATLPC0012326
Identity concordance
Identity concordance
Exact reported notation

Reported sequence string matches the current peptide notation.

0 / 21
Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 21
Different notation

Reported notation does not resolve to the current display sequence.

0 / 21
Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

21 / 21
Reported sequence notation

No source-specific sequence notation has been captured in the current identity references.

Current identity
FNAPFDVGIKLSGAQYQQHGRAL
Reported names
No distinct human-readable aliases are exposed.
Reference map3 reference groups
Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

ReferenceSupportsReported identityRecords
Reference
Open
PersistenceStability
Half Life, Protease Stability
No reported alias
16 identity
15 evidence
Reference
Open
PersistenceStability
Half Life, Serum Plasma Stability
No reported alias
4 identity
4 evidence
Reference
Open
Persistence
Half Life
No reported alias
1 identity
1 evidence
08

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

·
Record scopePublic release
ATL peptide ID
ATLPC0012326
Identity type
canonical sequence
ADMET endpoints
3
Evidence records
21
Reference groups
3
Release view
Public release
Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements
Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint
GET /api/v1/peptides/ATLPC0012326
open
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0012326' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'
ADMETatlas
peptide evidence atlas

ADMETatlas is an open, curated atlas of ADMET evidence for therapeutic peptides — spanning developability, membrane permeability and blood–brain-barrier transport, immune-recognition context, and approved-product context. Every measurement stays linked to its original source, with stable identifiers and transparent curation, so results can be traced, cited, and reproduced.

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