Peptide·plain sequence-like

ATLPC0023254

FNAPFDVGIKLSGVQYQQHSQAL

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Length
23 aa
Monoisotopic mass
2546.3 Da
Net charge @ pH 7.4
0.10
Isoelectric point
7.54
GRAVY
-0.161

Coveragecounts only · not riskATLPC0023254

Measurements
6
Endpoints
2
Domains
2/5
Products
—

2 stability measurements
4 clearance measurements
No immunogenicity context
No sequence liability cues

Jump to domain

Open the matching evidence section below

All evidence index · 6

Exposure / Absorption

No evidence

Distribution / Barrier

No evidence

Metabolic & Proteolytic Stability

2 measurements

Excretion / Persistence

4 measurements

Toxicity / Safety

No evidence

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

Identity summaryCanonical sequence only

Identity status: Canonical sequence only
Residues: 23
Peptidoform features: 0
Documented molecular forms: 1
Representations: 2

Documented molecular forms1 form linked to this peptide identity

Form	Topology	Modifications	Connections	Representations	Measurements
ATLPF0025391	—	—	—	Notation only	1

Residue view

Residue display

23 residues

F1N2A3P4F5D6V7G8I9K10L11S12G13V14Q15Y16Q17Q18H19S20Q21A22L23

Side-chain classNonpolarPolarBasic (+)Acidic (−)Modified

Soft tints mark standard side-chain classes for scanning. Primary emphasis is reserved for reported modifications, termini, secondary-structure tracks, and topology links.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

Chemical representationsequence / HELM only

Representation class

How the current release can interpret this identity chemically.

plain sequence-like

Parent-residue sequence

Residue string used for positional interpretation when available.

FNAPFDVGIKLSGVQYQQHSQAL

HELM

Polymer notation for modified peptide representation when available.

Not available

SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available

No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure referencesnone attached

3D structure not available

A 3D structure isn't available for this peptide in the current release. Chemistry and topology fields remain available when represented by sequence, HELM, or SMILES.

Covalent topology & modificationsnone

Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

Physicochemical profile

4 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

Core descriptors23 aa · pI 7.5 · GRAVY -0.16

Length: 23 aa
Monoisotopic mass: 2546.29 Da
Average mass: 2547.85 Da
Net charge at pH 7.4: 0.10
Estimated pI: 7.54
GRAVY: -0.161
KD-positive residues: 39.1%
Aromatic residues: 13.0%

Developability interpretation

Ionization context: pH 7.4 close to pI
Hydrophobicity balance: Leans hydrophilic
Amphipathic moment (μH): 0.46
Computation boundary: Standard-sequence only

Charge & residue composition

pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2

2.96

pH 5

1.08

pH 6

0.77

pH 7.4

0.05

pH 9

-0.80

pH 12

-2.93

Residue-class composition

Grouped composition is often more interpretable than a long amino-acid list.

Acidic (D,E)

1 · 4.3%

Basic (K,R,H)

2 · 8.7%

Polar uncharged (N,Q,S,T)

7 · 30.4%

Hydrophobic aliphatic (A,V,I,L,M)

7 · 30.4%

Aromatic (F,W,Y)

3 · 13.0%

Conformational / sulfur (G,P,C)

3 · 13.0%

Top residues

Q417.4%A28.7%G28.7%L28.7%F28.7%S28.7%V28.7%N14.3%

Hydropathy & amphipathic windows

Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window

3-9

APFDVGI

GRAVY 1.114

Most hydrophilic window

15-21

QYQQHSQ

GRAVY -2.757

17 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.

Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

12 aa window

1-12

FNAPFDVGIKLS

μH 0.83 · charge 0.0

12 aa window

6-17

DVGIKLSGVQYQ

μH 0.72 · charge 0.0

12 aa window

2-13

NAPFDVGIKLSG

μH 0.70 · charge 0.0

15 aa window

2-16

NAPFDVGIKLSGVQY

μH 0.55 · charge 0.0

12 aa window

3-14

APFDVGIKLSGV

μH 0.50 · charge 0.0

Sequence-liability cues

Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

No conservative sequence-liability motifs from the current rule set are present.

Alpha-helix amphipathic projection

Helical wheel · Edmundson projection

μ_H = 0.46100°/residue · 23 aa

Hydrophobic moment0.46

Mean K-D hydropathy-0.16

Approx. net charge0

Projection angle100° / residue

The pale sector marks the direction of the hydrophobic face inferred from μ_H. This is a projection assumption, not a measured fold.

HydrophobicAromaticPolarBasic +Acidic −Specialhydrophobic faceμ_H arrow → hydrophobic face

The projection assumes an α-helix conformation; a long μ_H arrow indicates an amphipathic helix, common in antimicrobial peptides.

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Sequence-derived

Computed from the standard parent-residue sequence; protein-origin metrics defined at any length.

Aliphatic index

84.78

Instability index

30.4

At or below 40 — predicted stable in vitro.

Boman index

0.89 kcal/mol

Molar extinction coefficient (280 nm)

1,490 M⁻¹·cm⁻¹

A280 (1 g/L) ≈ 0.58

Structure-derived descriptors are not shown because this identity has no resolved chemical structure (SMILES). This is a known coverage gap for disulfide-rich and unresolved peptidoforms, not a computation error.

Metabolic & Proteolytic Stability

2 records

How stable is the peptide in biological matrices or protease systems?

Evidence records

Complete canonical measurements and observations attached to this domain.

Endpoint scope

Formal ADMET endpoints represented for this peptide.

Matched-context analysis

Quantitative results that may be analysed only with scientifically compatible records.

Reported-result review

Qualitative, narrative, or review-first results interpreted in their source context.

Endpoints in scopeSerum/plasma stability

Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis

Quantitative results whose endpoint and context must still be matched before analysis.

Interpret as reported

Qualitative, narrative, or review-first findings preserved in source context.

Supporting context only

Reference, label, clinical, or supporting context for interpretation.

Review before analysis

Records whose present structure does not establish a safe analysis role.

Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

Serum/plasma stability2 records · 0 matched-context · 2 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	3905.9999999999995 seconds	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse plasma	Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse plasma · in vitro · Source: Primary reference linked	Reference
2	5748 seconds	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse plasma with protease inhibitor cocktail	Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse plasma + protease inhibitor cocktai · in vitro · Source: Primary reference linked	Reference

Excretion / Persistence

4 records

What evidence describes clearance or persistence?

Evidence records

Complete canonical measurements and observations attached to this domain.

Endpoint scope

Formal ADMET endpoints represented for this peptide.

Matched-context analysis

Quantitative results that may be analysed only with scientifically compatible records.

Reported-result review

Qualitative, narrative, or review-first results interpreted in their source context.

Endpoints in scopeHalf Life

Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis

Quantitative results whose endpoint and context must still be matched before analysis.

Interpret as reported

Qualitative, narrative, or review-first findings preserved in source context.

Supporting context only

Reference, label, clinical, or supporting context for interpretation.

Review before analysis

Records whose present structure does not establish a safe analysis role.

Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

Half Life4 records · 0 matched-context · 4 as reported · 0 context only · 0 review required

#	Value	Analysis use	Assay / model	Result context	Reference
1	4062 seconds	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse kidney membrane homogenate	Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse membrane homogenate · in vitro · Source: Primary reference linked	Reference
2	906 seconds	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse liver homogenate	Result: Reported point value · Molecular form: ATLPF0025391 · Dose/window: 90 μg · Proteases from Mouse liver homogenate · in vitro · Source: Primary reference linked	Reference
3	798 seconds	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse liver homogenate	Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse liver homogenate · in vitro · Source: Primary reference linked	Reference
4	1680 seconds	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse liver homogenate with protease inhibitor cocktail	Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse liver homogenate+protease inhibitor cocktai · in vitro · Source: Primary reference linked	Reference

Evidence landscape

6 records

Cross-domain evidence distribution and measurement-level detail; the domain modules above show evidence in context, and every row remains available for audit here.

Evidence landscape

A cross-domain view of evidence volume, scientifically permitted analysis use, and source traceability.

ADMET domain

Eligible when context matches

Interpret as reported

Supporting context only

Review before analysis

Exposure / Absorption

0 evidence records

Distribution / Barrier

0 evidence records

Metabolic & Proteolytic Stability

2 evidence records

Excretion / Persistence

4 evidence records

Toxicity / Safety

0 evidence records

Endpoint distribution

Top evidence-bearing endpoint questions.

Half Life

Serum Plasma Stability

Assay context

Broad context buckets, useful before comparing values.

In vivo / route

Traceability

Reference-link availability for measurement-level audit.

Linked reference

Not linked

All evidence index

Every evidence record remains available for audit and drilldown. Counts describe evidence volume, not confidence.

DomainAnalysis useReferenceMatrix

#	ADMET domain	Endpoint	Reported value	Result type	Analysis use	Assay / model	Condition	Reference
1	Excretion / Persistence Persistence	Half Life	798 seconds	Reported point value	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse liver homogenate	Dose/window: 90 μg · Protease: Proteases from mouse liver homogenate · in vitro	Reference Primary reference linked
2	Excretion / Persistence Persistence	Half Life	906 seconds	Reported point value	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse liver homogenate	Dose/window: 90 μg · Protease: Proteases from Mouse liver homogenate · in vitro	Reference Primary reference linked
3	Excretion / Persistence Persistence	Half Life	4,062 seconds	Reported point value	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse kidney membrane homogenate	Dose/window: 90 μg · Protease: Proteases from mouse membrane homogenate · in vitro	Reference Primary reference linked
4	Metabolic & Proteolytic Stability Stability	Serum Plasma Stability	5,748 seconds	Reported point value	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse plasma with protease inhibitor cocktail	Dose/window: 90 μg · Protease: Proteases from mouse plasma + protease inhibitor cocktai · in vitro	Reference Primary reference linked
5	Metabolic & Proteolytic Stability Stability	Serum Plasma Stability	3,906 seconds	Reported point value	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse plasma	Dose/window: 90 μg · Protease: Proteases from mouse plasma · in vitro	Reference Primary reference linked
6	Excretion / Persistence Persistence	Half Life	1,680 seconds	Reported point value	Interpret as reported	HPLC, LC-UV/MS · mouse · Mouse liver homogenate with protease inhibitor cocktail	Dose/window: 90 μg · Protease: Proteases from mouse liver homogenate+protease inhibitor cocktai · in vitro	Reference Primary reference linked

1–6 / 6

Identity & reference map

6 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

Summary1 reference group

Identity type: canonical sequence
Reported notation: 0
Reference groups: 1
Measurements: 6
ATL peptide ID: ATLPC0023254

Identity concordance

Exact reported notation

Reported sequence string matches the current peptide notation.

0 / 6

Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 6

Different notation

Reported notation does not resolve to the current display sequence.

0 / 6

Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

6 / 6

Reported sequence notation

No source-specific sequence notation has been captured in the current identity references.

Current identity

FNAPFDVGIKLSGVQYQQHSQAL

Reported names

No distinct human-readable aliases are exposed.

Reference map1 reference group

Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

Reference	Supports	Reported identity	Records
Reference Open	PersistenceStability Half Life, Serum Plasma Stability	No reported alias	6 identity 6 evidence

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

Record scopePublic release

ATL peptide ID: ATLPC0023254
Identity type: canonical sequence
ADMET endpoints: 2
Evidence records: 6
Reference groups: 1
Release view: Public release

Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements

Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint

GET /api/v1/peptides/ATLPC0023254

open

curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0023254' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'

Form

Topology

Modifications

Connections

Representations

Measurements

ATLPF0025391

—

Notation only

Value

Analysis use

Assay / model

Result context

Reference

3905.9999999999995 seconds

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse plasma

Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse plasma · in vitro · Source: Primary reference linked

Reference

5748 seconds

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse plasma with protease inhibitor cocktail

Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse plasma + protease inhibitor cocktai · in vitro · Source: Primary reference linked

Reference

Value

Analysis use

Assay / model

Result context

Reference

4062 seconds

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse kidney membrane homogenate

Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse membrane homogenate · in vitro · Source: Primary reference linked

Reference

906 seconds

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse liver homogenate

Result: Reported point value · Molecular form: ATLPF0025391 · Dose/window: 90 μg · Proteases from Mouse liver homogenate · in vitro · Source: Primary reference linked

Reference

798 seconds

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse liver homogenate

Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse liver homogenate · in vitro · Source: Primary reference linked

Reference

1680 seconds

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse liver homogenate with protease inhibitor cocktail

Result: Reported point value · Molecular form: ATLPF0041102 · Dose/window: 90 μg · Proteases from mouse liver homogenate+protease inhibitor cocktai · in vitro · Source: Primary reference linked

Reference

ADMET domain

Endpoint

Reported value

Result type

Analysis use

Assay / model

Condition

Reference

Excretion / Persistence

Persistence

Half Life

798 seconds

Reported point value

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse liver homogenate

Dose/window: 90 μg · Protease: Proteases from mouse liver homogenate · in vitro

Reference

Primary reference linked

Excretion / Persistence

Persistence

Half Life

906 seconds

Reported point value

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse liver homogenate

Dose/window: 90 μg · Protease: Proteases from Mouse liver homogenate · in vitro

Reference

Primary reference linked

Excretion / Persistence

Persistence

Half Life

4,062 seconds

Reported point value

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse kidney membrane homogenate

Dose/window: 90 μg · Protease: Proteases from mouse membrane homogenate · in vitro

Reference

Primary reference linked

Metabolic & Proteolytic Stability

Stability

Serum Plasma Stability

5,748 seconds

Reported point value

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse plasma with protease inhibitor cocktail

Dose/window: 90 μg · Protease: Proteases from mouse plasma + protease inhibitor cocktai · in vitro

Reference

Primary reference linked

Metabolic & Proteolytic Stability

Stability

Serum Plasma Stability

3,906 seconds

Reported point value

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse plasma

Dose/window: 90 μg · Protease: Proteases from mouse plasma · in vitro

Reference

Primary reference linked

Excretion / Persistence

Persistence

Half Life

1,680 seconds

Reported point value

Interpret as reported

HPLC, LC-UV/MS · mouse · Mouse liver homogenate with protease inhibitor cocktail

Dose/window: 90 μg · Protease: Proteases from mouse liver homogenate+protease inhibitor cocktai · in vitro

Reference

Primary reference linked

Reference

Supports

Reported identity

Records

Reference

Open

PersistenceStability

Half Life, Serum Plasma Stability

No reported alias

6 identity

6 evidence

ATLPC0023254

Sequence & molecular identity

Sequence & peptidoform

Structure & chemistry

Physicochemical profile

Computed developability descriptors

Metabolic & Proteolytic Stability

Excretion / Persistence

Evidence landscape

Product context

Identity & reference map

Data access & reproducibility

Structured peptide profile

Peptide catalogue

Measurement catalogue

ATLPC0023254

Sequence & molecular identity

Sequence & peptidoform

Structure & chemistry

Physicochemical profile

Computed developability descriptors

Metabolic & Proteolytic Stability

Excretion / Persistence

Evidence landscape

Product context

Identity & reference map

Data access & reproducibility

Structured peptide profile

Peptide catalogue

Measurement catalogue