- Route
- subcutaneous
- Form
- Injection
- Holder
- Eton Pharmaceuticals, Inc.
- Scope
- Direct label match
Mecasermin
ATLPD0000067
Product-level evidence profile for identity and molecular form, PK exposure, clinical context, safety context, label material, and reproducible data access.
- ADMETatlas IDATLPD0000067
- Peptide-link statusDefined molecular entity
- Linked peptides1
- Product routenot established
- PK summaries6
- Trial references25
- Matched label records3
- Regulatory-label PK7
Product evidence profile
Product identity and molecular form, PK exposure evidence, safety context, clinical and label context, interpretation boundaries, and reproducibility exits available for this product.
What is this product, which peptide does it map to, and what is its structure?
What is the drug used for and how does it act?
Are there curated exposure / PK summaries or cited observations?
What safety, postmarketing, and immune-recognition signals surround the product?
What trial and product-label context is attached to this product?
How is the evidence scoped, traced, cited, and reopened?
One. Molecular identity & structure
What the product is, how its complete molecular form is defined, and which chemical or structural representations support that identity.
Identity
Mecasermin
ATLPD0000067This product identity anchors product-level label, trial, postmarketing, and PK context. Route, form, and holder fields are shown when they are normalized from product or label references, not inferred from the product name.
- Product name
- Mecasermin
- ADMETatlas product ID
- ATLPD0000067
- Aliases / marketed names
- Increlex
These anchors support product-level lookup and context attachment. They are identity evidence, not ADMET endpoint measurements.
- H01AC03 · mecasermin
ATC classification © WHO Collaborating Centre for Drug Statistics Methodology; used unmodified for non-commercial research.
Label formulation evidence
- Route
- subcutaneous
- Form
- Injection, solution
- Holder
- Ipsen Biopharmaceuticals, Inc.
- Scope
- Direct label match
- Route
- oral
- Form
- Capsule
- Holder
- Viatrexx Bio Incorporated
- Scope
- Combination label
| Label / formulation | Route | Form | Holder | Context | Reference |
|---|---|---|---|---|---|
INCRELEX (MECASERMIN) INJECTION [ETON PHARMACEUTICALS, INC.] May 20, 2026 | subcutaneous | Injection | Eton Pharmaceuticals, Inc. | Direct label match | DailyMed record |
INCRELEX (MECASERMIN) INJECTION, SOLUTION [IPSEN BIOPHARMACEUTICALS, INC.] Aug 07, 2025 | subcutaneous | Injection, solution | Ipsen Biopharmaceuticals, Inc. | Direct label match | DailyMed record |
MUSKEL (ANTI-INTERLEUKIN-1.ALPHA. IMMUNOGLOBULIN G RABBIT, BOS TAURUS ANKLE JOINT, SUS SCROFA ANKLE JOINT, BOS TAURUS JOINT CAPSULE, SUS SCROFA JOINT CAPSULE, BRAIN-DERIVED NEUROTROPHIC FACTOR HUMAN, METENKEFALIN, ERSOFERMIN, BOS TAURUS SOLAR PLEXUS, SUS SCROFA SOLAR PLEXUS, CALCITONIN, BOS TAURUS FRONTAL LOBE, SUS SCROFA FRONTAL LOBE, BOS TAURUS HIP JOINT, SUS SCROFA HIP JOINT, BOS TAURUS HIPPOCAMPUS, SUS SCROFA HIPPOCAMPUS, BOS TAURUS HYPOTHALAMUS, SUS SCROFA HYPOTHALAMUS, MECASERMIN RINFABATE) SPRAY [VIATREXX BIO INCORPORATED] Dec 02, 2022 | oral | Capsule | Viatrexx Bio Incorporated | Combination label | DailyMed record |
Linked peptide identity
Product-level label, safety, trial, and PK context may be read beside the linked peptide identity. Endpoint truth still remains controlled by endpoint-specific evidence and compatibility rules.
The public link view emphasizes sequence, identity role, reference support, and interpretation boundary rather than non-public peptide identifiers.
- Identity role
- Reference identity
- Sequence
- GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
- Residue length
- 70 residues
- Reference support
- 0 supporting references
Multiple linked identities can reflect reviewed source-sequence differences, variant entries, or precursor-like entries. Use the reference identity as the main product-context link.
The link supports product-context interpretation beside a peptide identity. It is not a measured endpoint, and it does not promote label, safety, or trial context into peptide-level endpoint truth by itself.
Structure depiction isn't available for this peptide in the current release. The linked peptide record carries the reviewed sequence and any predicted model.
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Two. Pharmacology: indication & mechanism
What the drug is used for and how it acts, based on curated therapeutic indications and mechanism-of-action evidence for the product identity.
Indication & mechanism of action
Three. Pharmacokinetics & exposure
Traceable exposure and PK properties across product labels, literature, and nonclinical evidence.
Pharmacokinetics & exposure
Traceable exposure properties
Human product-label values are shown first, followed by additional source-backed evidence.
Human exposure properties reported in official product labeling.
Other source-backed PK properties across labels, literature, and nonclinical studies.
Direct source values extend the product's PK endpoint profile.
Cited measurement trace7 observations
- Context
- human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD
- Measured material
- Reported analyte
- Evidence role
- Source-reported product-label value
- Reference
- Reference
- Context
- human · subcutaneous · healthy subjects
- Measured material
- Reported analyte
- Evidence role
- Source-reported product-label value
- Reference
- Reference
- Context
- human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD
- Measured material
- Reported analyte
- Evidence role
- Source-reported product-label value
- Reference
- Reference
- Context
- human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD
- Measured material
- Reported analyte
- Evidence role
- Source-reported product-label value
- Reference
- Reference
- Context
- human · whole_blood
- Measured material
- Reported analyte
- Evidence role
- Source-reported observation
- Reference
- Reference
- Context
- human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD
- Measured material
- Reported analyte
- Evidence role
- Source-reported product-label value
- Reference
- Reference
- Context
- human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD
- Measured material
- Reported analyte
- Evidence role
- Source-reported product-label value
- Reference
- Reference
| PK property | Value | Context | Reference | Measured material | Evidence role | Reported statement |
|---|---|---|---|---|---|---|
| AUC | 2,932 ng*h/mL | human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD | Reference | Reported analyte | Source-reported product-label value | Table 1. Summary of INCRELEX Single-Dose Pharmacokinetic Parameters in Children with Severe Primary IGFD (0.12 mg/kg, SC) C max (ng/mL) T max (hr) AUC 0-8 (hr*ng/mL) t 1/2 (hr) Vd/F (L/kg) CL/F (L/hr/kg) n 3 3 3 3 12 ... |
| Bioavailability | ≈100 % | human · subcutaneous · healthy subjects | Reference | Reported analyte | Source-reported product-label value | The absolute bioavailability of rhIGF-1 after subcutaneous administration in healthy subjects is estimated to be close to 100%. However, the absolute bioavailability of INCRELEX given subcutaneously to subjects with p... |
| Clearance | 0.0424 L/h/kg | human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD | Reference | Reported analyte | Source-reported product-label value | Table 1. Summary of INCRELEX Single-Dose Pharmacokinetic Parameters in Children with Severe Primary IGFD (0.12 mg/kg, SC) C max (ng/mL) T max (hr) AUC 0-8 (hr*ng/mL) t 1/2 (hr) Vd/F (L/kg) CL/F (L/hr/kg) n 3 3 3 3 12 ... |
| Cmax | 234 ng/mL | human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD | Reference | Reported analyte | Source-reported product-label value | Table 1. Summary of INCRELEX Single-Dose Pharmacokinetic Parameters in Children with Severe Primary IGFD (0.12 mg/kg, SC) C max (ng/mL) T max (hr) AUC 0-8 (hr*ng/mL) t 1/2 (hr) Vd/F (L/kg) CL/F (L/hr/kg) n 3 3 3 3 12 ... |
| PPB | >80 % | human · whole_blood | Reference | Reported analyte | Source-reported observation | In blood, IGF-1 is bound to six IGF binding proteins, with > 80% bound as a complex with IGFBP-3 and an acid-labile subunit. |
| Tmax | 7,200 seconds | human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD | Reference | Reported analyte | Source-reported product-label value | Table 1. Summary of INCRELEX Single-Dose Pharmacokinetic Parameters in Children with Severe Primary IGFD (0.12 mg/kg, SC) C max (ng/mL) T max (hr) AUC 0-8 (hr*ng/mL) t 1/2 (hr) Vd/F (L/kg) CL/F (L/hr/kg) n 3 3 3 3 12 ... |
| Vd | 0.257 L/kg | human · subcutaneous · 0.12 mg/kg · plasma · children with severe Primary IGFD | Reference | Reported analyte | Source-reported product-label value | Table 1. Summary of INCRELEX Single-Dose Pharmacokinetic Parameters in Children with Severe Primary IGFD (0.12 mg/kg, SC) C max (ng/mL) T max (hr) AUC 0-8 (hr*ng/mL) t 1/2 (hr) Vd/F (L/kg) CL/F (L/hr/kg) n 3 3 3 3 12 ... |
How PK values are grouped
Summaries keep species, unit, route, dose, matrix, population, and source context separate. Each value retains its cited measurement trace.
Four. Safety & immunogenicity
Regulatory safety warnings, postmarketing and nonclinical safety context, and immune-recognition context. These describe available signals, not incidence rates or causality.
Safety & immunogenicity
Five. Clinical & regulatory evidence
Clinical-trial context and structured product-label references attached by product identity.
Clinical & regulatory evidence
Six. Provenance, scope & access
How to read, trace, cite, and reopen this profile: evidence scope, reference lineage, and reproducible data access.
Evidence scope
Evidence roles stay separate before interpretation
Endpoint summaries, product-context lanes, identity links, and source references answer different questions. This boundary keeps the page useful without converting context into stronger claims than the current review layer supports.
Compare PK results only when endpoint and experimental context are compatible.
Label, trial, safety, immune, and nonclinical records remain contextual unless separately extracted as an endpoint.
Defined molecular entity
Detailed interpretation and provenance guidance
Comparable measurement layer
Endpoint-level interpretation when context fields match.
Pooled product parameters across mismatched species, units, route, dose, matrix, population, or source context.
Clinical, label, safety, immune, and nonclinical context
Reading the product's evidence surroundings and source-backed context lanes.
Incidence rates, causality claims, product safety ranking, or normalized ADMET endpoint values.
Molecular identity context
Reading product context beside a reviewed peptide identity.
Automatic transfer of every product-level signal to peptide-level endpoint evidence.
Reproducibility and source trace
Checking where labels, trials, safety reports, identity links, and curated measurements came from.
A substitute for normalized evidence, context grouping, or endpoint review.
Original-source reading path
Reading the source reference in its native regulatory, registry, literature, or source context.
Bypassing ADMETatlas curation status, interpretation boundaries, or endpoint-promotion policy.
Reference lineage
Source families are separated by scientific role
Label, trial, safety, immune, identity-link, and PK evidence enter the product profile through different review paths. This module keeps their roles visible so users can trace evidence without over-reading context counts.
active reference families
source-matching traces
PK plus context entries
current product profile
Regulatory product-label context
Label sections, label-derived PK statements, safety wording, route, formulation, and immunogenicity context when extracted.
Label material supports product context. It becomes endpoint evidence only through the reviewed PK or endpoint extraction path.
Human study-registration context
Trial identity, phase/status, intervention matching, and availability of results context around the product.
Trial registry entries are study context unless endpoint-compatible results are extracted and reviewed separately.
Safety surveillance context
Signal-aware reading of reported adverse-event context around marketed products.
Report counts do not establish causality, incidence, or comparative product safety.
Assay and nonclinical support context
Immune-recognition assays, nonclinical safety context, and neighboring signals that help interpret the product profile.
These entries are not clinical incidence or endpoint truth unless a review policy promotes a specific endpoint.
Named-product identity support
Matching named and dosed product presentations to a stable medication identity.
Identity records do not provide an endpoint value, administration outcome, or route-specific clinical result.
Source-matching and identity-review context
Source records used to assess product-to-peptide identity relationships and retained audit context.
Only an exact match to the current authoritative canonical identity supports a linked identity; all other traces remain product context.
Endpoint measurement trace
Rechecking source values, units, route, dose, matrix, population, and source context for PK summaries.
PK entries remain context-bound measurements and should not be pooled across incompatible contexts.
Link references and selected label entries carry direct source links. Product-context entries may instead carry source labels and curated summaries in the structured profile. Both are provenance, but only direct reference fields should be displayed as citation links.
Data access & citation
The structured profile access reopens the same product view used by this page, including molecular identity, PK evidence, product context, and reference lineage for the current public release.
public product profile
identity link scope
cited measurement trace
25 context · 6 identity support
label plus link traces
Use the product profile access for product-specific reproducibility. Use full-release downloads for catalog-scale analysis, with the current source policy and data dictionary.
Current product
Machine-readable profile for molecular identity, PK evidence summaries, product context, and reference lineage.
Uses the public ATL product ID in the URL. Non-public product identifiers remain outside the navigation label.
The request returns the structured product profile used by this page. It is the current product-specific reproducibility path while product-only tabular exports remain a release follow-up.
curl -sS 'https://admetatlas.scbdd.com/api/v1/products/ATLPD0000067' \
-H 'accept: application/json' \
-H 'X-Visibility: public_release'Use this module to reproduce the current product profile and locate full-release exports. Cross-product comparison still depends on compatible endpoint, species, route, dose, matrix, population, source, identity-link, and review context.