Evidence — ADMETatlas

Evidence entries

149records·502linked peptides

Showing reference-linked Serum/plasma stability evidence with reported value, assay context, interpretation role, and reference access kept separate.

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All149 Curated comparable883 Reported149

#	Endpoint	Measured entity		Assay context	Evidence role	Reference
1	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0001635 Specific molecular form	Observation Slightly lower stability than TXIB	RP-UPLCMale AB human serumhumanAliquots of each peptide were taken out at 0, 12, 24, 36, and 48 h.100 μM	Reported	Reference
2	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0014180 Specific molecular form	21,240 seconds	stability	Reported	Reference
3	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0031376 Specific molecular form	Observation Medium Stable	RP-HPLCMouse blood/plasma/serummouseAliquots (20 or 40 μL) taken after 0 and 60 min (0, 10 and 30 min for Api88)31.5 μmol/L	Reported	Reference
4	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0023033 Specific molecular form	Observation Degradation occured initially after 10 min	HPLCHuman serumhuman128, 64, 32, 16, 8, 4, 2, 1, and 0.5 μM	Reported	Reference
5	Serum/plasma stability Metabolic & Proteolytic Stability	Measured entity Not resolved	Observation Degraded quickly with half-lives of less than 0.5 h and are completely gone after 2 h.	stability	Reported	Reference
6	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0033682 Specific molecular form	Observation 77% Stable	Radio-HPLCHuman blood plasmahumanAfter 24 hrs at 37 ◦C7.5 MBq	Reported	Reference
7	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0002239 Specific molecular form	34,560 seconds	stability	Reported	Reference
8	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0020216 Specific molecular form	Observation Stable	LC-MS80% pooled human Li-heparin plasmahumanAt selected time points samples were taken: 5, 15, 30, 60, 120, 210, 300 mins1 μM	Reported	Reference
9	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0033682 Specific molecular form	Observation 77% Stable	Radio-HPLCHuman blood plasmahumanAfter 24 hrs at 37 ◦C7.5 MBq	Reported	Reference
10	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0021997 Specific molecular form	Observation More Stable Than Ex-4	LC-MS/ MSRats plasmaratAt 0, 1, 2, 4, 6, 8, 12, 24, 36, 48 and 72 h time points1000 ng/mL	Reported	Reference
11	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0007356 Specific molecular form	18,360 seconds	stability	Reported	Reference
12	Serum/plasma stability Metabolic & Proteolytic Stability	Measured entity Not resolved	Observation The antimicrobial activity of cyclic-C1-15 was lost after 3h	stability	Reported	Reference
13	Serum/plasma stability Metabolic & Proteolytic Stability	Measured entity Not resolved	Observation Have half-lives of about 1 h, still almost fully degraded after 2 h.	stability	Reported	Reference
14	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0035155 Specific molecular form	Observation 94.9 of intact tracers remained	radio-HPLCmouse serummouse1 hour∼100 μCi	Reported	Reference
15	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0027736 Specific molecular form	Observation N.A.	Not specified	Reported	Reference
16	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0022129 Specific molecular form	Observation Stability increased	stability	Reported	Reference
17	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0029360 Specific molecular form	Observation Stable	LC-MS80% pooled human Li-heparin plasmahumanAt selected time points samples were taken: 5, 15, 30, 60, 120, 210, 300 mins1 μM	Reported	Reference
18	Serum/plasma stability Metabolic & Proteolytic Stability	Peptide ATLPC0014785 Specific molecular form	Observation Stable	RP-UPLCHuman serumhuman0.25 mM	Reported	Reference
19	Serum/plasma stability Metabolic & Proteolytic Stability	Measured entity Not resolved	Observation Have half-lives of about 1 h, still almost fully degraded after 2 h.	stability	Reported	Reference
20	Serum/plasma stability Metabolic & Proteolytic Stability	Measured entity Not resolved	Observation More than 70% of peptides remain intact after 6.5 h.	stability	Reported	Reference

1–20 / 149

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