Failure-mode evidence depth
Stack
Reviewed sequence, HELM, or SMILES representation used to interpret this peptide identity.
Molecular graph, chemical representation, 3D references, and covalent topology when available.
Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity.
Product-level route, label, and clinical context that frames peptide-level evidence.
What evidence describes systemic exposure or absorption?
What is known about distribution, binding, permeability, or barrier crossing?
How stable is the peptide in biological matrices or protease systems?
What evidence describes clearance or persistence?
Cross-domain evidence distribution, traceability, and measurement-level detail for this peptide.
Reference-level support for checking reported names, sequence notation, and peptide identity agreement.
Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.
Are molecular graph, topology, or 3D coordinates available?
Can basic developability descriptors be computed?
What safety, toxicity, or tolerability evidence is attached?
Not availablePolymer notation for modified peptide representation when available.
Not availableChemical graph string used for atom-level 2D depiction when available.
Not availableA reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.
A 3D structure isn't available for this peptide in the current release. Chemistry and topology fields remain available when represented by sequence, HELM, or SMILES.
No disulfide, staple, coordination, other cross-link, or residue-level modification annotation is attached to this peptide in the current release.
Interpretation: A 2D graph describes connectivity, not conformation. A 3D reference describes one coordinate model or solved state, not the full ensemble. ADMET interpretation should account for peptidoform, topology, and assay context together.
3 Ro5 violations · MW 1,209.42 Da
Reviewed observations retained without being collapsed into comparable values.
Endpoints define the scientific questions in this domain; the measurements below carry the values and assay context.
Bioavailability, AUC, Cmax, and Tmax evidence.
The same three research-facing layers are used across ADMETatlas.
Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | Observation Bioavailability by subcutaneous administration is comparable to that by intravenous administration. | Reported | DailyMed SPL 12.3 Pharmacokinetics label extraction · human | Route: subcutaneous · Leuprolide· Pharmacokinetics · bioavailability sc comparable to iv text · Bioavailability... | Open |
| 2 | Observation Bioavailability by subcutaneous administration is comparable to that of intravenous administration | Reported | PepTherDia curated product PK field | Route: SC, IM, TOPICAL · 4 · Leuprolide · exact product name match · exact or normalized match | Open |
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | 138 ng*h/mL | Comparable | AUC in overnight fasted C57BL/6N mouse at 1 mg/kg, ip · mouse | Route: ip · area under curve · AUC· AUC in overnight fasted C57BL/6N mouse at 1 mg/kg, ip · Exact ChE... | Open |
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | 157.1 nM | Comparable | Cmax in overnight fasted C57BL/6N mouse at 1 mg/kg, ip · mouse | Route: ip · max concentration · Cmax· Cmax in overnight fasted C57BL/6N mouse at 1 mg/kg, ip · Exact... | Open |
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | 1 hr 3600 seconds | Comparable | Tmax in overnight fasted C57BL/6N mouse at 1 mg/kg, ip · mouse | Route: ip · time to max concentration · Tmax· Tmax in overnight fasted C57BL/6N mouse at 1 mg/kg, ip... | Open |
Interpretation: Exposure and absorption values should be compared only within matching route, dose, matrix, population, and unit context.
Reviewed observations retained without being collapsed into comparable values.
Endpoints define the scientific questions in this domain; the measurements below carry the values and assay context.
Distribution volume, plasma protein binding, permeability, and BBB penetration evidence.
The same three research-facing layers are used across ADMETatlas.
Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | 27 L | Comparable | DailyMed SPL 12.3 Pharmacokinetics label extraction · human | Route: intravenous · Leuprolide· Pharmacokinetics · volume of distribution single · Distribution The mean stea... | Open |
| 2 | 0.38 L/kg | Comparable | Volume of distribution at steady state in human after iv administration · human | Route: iv · volume of distribution · Vdss· Volume of distribution at steady state in human after iv a... | Open |
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | 43-49 % | Comparable | DailyMed SPL 12.3 Pharmacokinetics label extraction · human · plasma | Leuprolide· Pharmacokinetics · plasma binding human plasma protein ranged percent · In vi... | Open |
| 2 | 43-49 % | Comparable | PepTherDia curated product PK field · plasma protein | Route: SC, IM, TOPICAL · 4 · Leuprolide · exact product name match · exact or normalized match | Open |
PAMPA, Caco-2, MDCK/RRCK, and BBB findings are assay/model contexts under Distribution / Barrier. They should not be read as interchangeable measurements.
artificial membrane
cell monolayer
cell monolayer
cell monolayer
barrier evidence
Interpretation: Distribution, protein binding, PAMPA, cell-monolayer, and BBB evidence are not interchangeable without matching assay/model context.
Reviewed observations retained without being collapsed into comparable values.
Endpoints define the scientific questions in this domain; the measurements below carry the values and assay context.
Serum/plasma stability and protease stability evidence.
The same three research-facing layers are used across ADMETatlas.
Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | 2292 seconds | Comparable | UPLC-MS/MS · rat · Male SD rats plasma | Dose/window: 0.1 mg/kg · Time: Blood sample of approximately 0.3 mL was collected via femoral artery cannulation at various time points (0,... · Male SD Rats Plasma Protease · In Vivo | Open |
| 2 | 166 ± 38 Minutes 9960 seconds | Comparable | UPLC-MS/MS · rat · Male SD rats plasma after LOC peptide administration | Route: SC (after administration of LOC) · Dose/window: 0.1 mg/kg · Time: Blood sample of approximately 0.3 mL was collected via femoral artery cannulation at various time points (0,... · Male SD Rats Plasma Protease · In Vivo | Open |
Interpretation: In vitro stability, protease stability, and percent-remaining measurements are not collapsed into one value.
Reviewed observations retained without being collapsed into comparable values.
Endpoints define the scientific questions in this domain; the measurements below carry the values and assay context.
Clearance and half-life evidence.
The same three research-facing layers are used across ADMETatlas.
Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.
| # | Value | Evidence layer | Assay / model | Condition | Reference |
|---|---|---|---|---|---|
| 1 | 2 mL/min/kg | Comparable | Clearance in human after iv administration · human | Route: iv · clearance · CL· Clearance in human after iv administration · Exact ChEMBL pref name LEUPR... | Open |
| 2 | 0.007 mL/h | Comparable | Clearance in overnight fasted C57BL/6N mouse at 1 mg/kg, ip · mouse | Route: ip · clearance · CL· Clearance in overnight fasted C57BL/6N mouse at 1 mg/kg, ip · Exact ChEMB... | Open |
| 3 | 9 mL/min/kg | Comparable | Clearance in rat after iv dose (100 ug/kg) · rat | Route: iv · clearance · CL· Clearance in rat after iv dose (100 ug/kg) · Exact ChEMBL pref name LEUPR... | Open |
| 4 | 7.6 L/h | Comparable | DailyMed SPL 12.3 Pharmacokinetics label extraction · human | Route: intravenous · Leuprolide· Pharmacokinetics · clearance single · Metabolism In healthy male volunteers,... | Open |
Interpretation: Clearance and half-life require route, matrix, species/population, and time-scale context before comparison.
Reported sequence string matches the current peptide notation.
Reported notation differs, but resolves to the same parent-residue display.
Reported notation does not resolve to the current display sequence.
The identity reference does not expose a sequence string.
No reported sequence notation is available in the current identity references.
No sequence representation
Grouped by reference link, with endpoint scope and reported identity kept visible.
| Reference | Supports | Reported identity | Records |
|---|---|---|---|
PubMed 36557850 | Stability Serum Plasma Stability | No reported alias | 2 identity 2 evidence |
PubMed 23127987 | ExposurePersistence Area Under Curve, Clearance, Max Concentration, Time To Max Concentration | No reported alias | 0 identity 4 evidence |
Reference link | DistributionExposurePersistence Bioavailability, Clearance, Plasma Protein Binding, Volume Of Distribution | No reported alias | 0 identity 4 evidence |
Reference link | DistributionExposure Bioavailability, Plasma Protein Binding | No reported alias | 1 identity 2 evidence |
PubMed 18426954 | DistributionPersistence Clearance, Volume Of Distribution | No reported alias | 0 identity 2 evidence |
PubMed 8381183 | Persistence Clearance | No reported alias | 0 identity 1 evidence |
Interpretation: Reference links and reported notations help confirm that measurements point to the same peptide identity or a compatible peptidoform. ADMET interpretation still belongs to the endpoint modules above, where assay/model and condition context are shown with each measurement.
Identity, sequence, profile-level fields, and current release view metadata.
Endpoint-level measurements attached to this peptide, suitable for review or reanalysis.
Nested peptide record for scripted retrieval, including identity and evidence context.
The request returns the same structured peptide record used by this profile. Measurement downloads use the same peptide identifier and public release visibility.
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0018293' \
-H 'accept: application/json' \
-H 'X-Visibility: public_release'Interpretation: Use these files as the reproducible data package for this peptide profile. Cross-peptide comparison still depends on compatible endpoints, assays, species or model systems, route, dose, matrix, and evidence layer.