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Peptide·plain sequence-like

Lixisenatide

ATLPC0015930

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK

Routes
Compare in workbenchDownload releaseAPI JSON
  • Length
    44 aa
  • Monoisotopic mass
    4856.5 Da
  • Net charge @ pH 7.4
    3.10
  • Isoelectric point
    10.33
  • GRAVY
    -1.109
On this page
  • 01 Sequence & molecular identity
  • 02 Physicochemical profile
  • 03 Exposure / Absorption
  • 04 Distribution / Barrier
  • 05 Metabolic & Proteolytic Stability
  • 06 Excretion / Persistence
  • 07 Evidence landscape
  • 08 Product context
  • 09 Identity & reference map
  • 10 Data access & reproducibility
Coveragecounts only · not riskATLPC0015930
  • Measurements
    14
  • Endpoints
    9
  • Domains
    4/5
  • Products
    1
  • 1 stability measurement
  • 4 clearance measurements
  • Product-level review pending
  • 2 liability motifs
Jump to domain

Open the matching evidence section below

All evidence index · 14
Exposure / Absorption
7 measurements
Distribution / Barrier
2 measurements
Metabolic & Proteolytic Stability
1 measurement
Excretion / Persistence
4 measurements
Toxicity / Safety
No evidence
01

Sequence & molecular identity

1 forms

Reviewed sequence, peptidoform forms, chemical representation, 3D references, and covalent topology used to interpret this peptide identity.

Sequence & peptidoform

·
Identity summaryCanonical sequence only
Identity status
Canonical sequence only
Residues
44
Peptidoform features
0
Documented molecular forms
1
Representations
2
Documented molecular forms1 form linked to this peptide identity
FormTopologyModificationsConnectionsRepresentationsMeasurements
ATLPF0017463—1—Notation only4
Residue view
Residue display
44 residues
H1G2E3G4T5F6T7S8D9L10S11K12Q13M14E15E16E17A18V19R20L21F22I23E24W25L26K27N28G29G30P31S32S33G34A35P36P37S38K39K40K41K42K43K44
Side-chain classNonpolarPolarBasic (+)Acidic (−)Modified

Soft tints mark standard side-chain classes for scanning. Primary emphasis is reserved for reported modifications, termini, secondary-structure tracks, and topology links.

Peptidoform features

Features are shown only when a reported notation or topology record supports them.

No terminal modification, residue-level marker, disulfide, staple, coordination, or other topology signal is currently available.

Structure & chemistry

·
Chemical representationsequence / HELM only
Representation class

How the current release can interpret this identity chemically.

plain sequence-like
Parent-residue sequence

Residue string used for positional interpretation when available.

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK
HELM

Polymer notation for modified peptide representation when available.

Not available
SMILES

Chemical graph string used for atom-level 2D depiction when available.

Not available
No atom-level graph

A reviewed SMILES is required before a 2D molecular depiction can be shown. Sequence and HELM remain useful for identity interpretation, but they do not replace a chemical graph.

3D structure references9 references
Structure reference·
3D coordinates·Sequence matchexperimental
Sequence match·reference selected·identity 100.0%·confidence experimental
LinkMethodConfidenceMatch
OpenSequence matchexperimental100.0% identity
OpenSequence matchexperimental100.0% identity
OpenSequence matchexperimental100.0% identity
OpenSequence matchexperimental100.0% identity
OpenSequence matchexperimental100.0% identity
OpenSequence matchexperimental100.0% identity
OpenSequence matchexperimental97.2% identity
OpenSequence matchexperimental97.2% identity
OpenSequence matchexperimental96.5% identity
Covalent topology & modificationsnone
Exact topology not established

No reviewed form-level topology or residue-level connection annotation is attached to this peptide in the current release. This is not evidence that every molecular form is linear or unmodified.

02

Physicochemical profile

4 descriptors

Computed sequence-derived descriptors and any measured physicochemical evidence such as lipophilicity. Computed values are interpretation aids, not experimental ADMET measurements.

·
Core descriptors44 aa · pI 10.3 · GRAVY -1.11
Length
44 aa
Monoisotopic mass
4856.53 Da
Average mass
4859.53 Da
Net charge at pH 7.4
3.10
Estimated pI
10.33
GRAVY
-1.109
KD-positive residues
22.7%
Aromatic residues
6.8%
Developability interpretation
Ionization context
pH 7.4 separated from pI
Hydrophobicity balance
Leans hydrophilic
Amphipathic moment (μH)
0.34
Computation boundary
Standard-sequence only
Charge & residue composition
pH charge context

Modeled net charge across common formulation and assay pH checkpoints.

pH 2
10.92
pH 5
4.64
pH 6
3.83
pH 7.4
3.05
pH 9
2.16
pH 12
-5.77
Residue-class composition

Grouped composition is often more interpretable than a long amino-acid list.

Acidic (D,E)
6 · 13.6%
Basic (K,R,H)
10 · 22.7%
Polar uncharged (N,Q,S,T)
9 · 20.5%
Hydrophobic aliphatic (A,V,I,L,M)
8 · 18.2%
Aromatic (F,W,Y)
3 · 6.8%
Conformational / sulfur (G,P,C)
8 · 18.2%
Top residues
K818.2%E511.4%G511.4%S511.4%L36.8%P36.8%A24.5%F24.5%
Hydropathy & amphipathic windows
Hydropathy windows

Seven-residue sliding windows expose local patches hidden by whole-sequence GRAVY.

Most hydrophobic window
17-23
EAVRLFI
GRAVY 1.300
Most hydrophilic window
38-44
SKKKKKK
GRAVY -3.457
38 local hydropathy windows scanned. A local patch is context for solubility, adsorption, and membrane interaction review, not a standalone endpoint.
Amphipathic-window scan

Top alpha-helix hydrophobic-moment windows across 12, 15, 18, and 21 residues.

12 aa window
17-28
EAVRLFIEWLKN
μH 1.99 · charge 0.0
12 aa window
16-27
EEAVRLFIEWLK
μH 1.87 · charge -1.0
12 aa window
18-29
AVRLFIEWLKNG
μH 1.69 · charge 1.0
15 aa window
17-31
EAVRLFIEWLKNGGP
μH 1.66 · charge 0.0
15 aa window
16-30
EEAVRLFIEWLKNGG
μH 1.61 · charge -1.0
Sequence-liability cues
Sequence-liability notes

Motifs are review prompts for formulation or CMC interpretation; they are not degradation predictions.

Asn deamidation motif
NG · pos 28
Asn followed by small/polar residues is a known sequence context to review for deamidation susceptibility.
Oxidation-sensitive residues
M, W · pos 14, 25
Met, Trp, and Cys residues can merit formulation review for oxidation or covalent-state sensitivity.
Alpha-helix amphipathic projection
Helical wheel · Edmundson projection
μH = 0.34100°/residue · 44 aa
μH1: H (His) · Basic + · K-D -3.2H12: G (Gly) · Special · K-D -0.4G3: E (Glu) · Acidic − · K-D -3.5E4: G (Gly) · Special · K-D -0.4G5: T (Thr) · Polar · K-D -0.7T56: F (Phe) · Aromatic · K-D 2.8F7: T (Thr) · Polar · K-D -0.7T8: S (Ser) · Polar · K-D -0.8S9: D (Asp) · Acidic − · K-D -3.5D10: L (Leu) · Hydrophobic · K-D 3.8L1011: S (Ser) · Polar · K-D -0.8S12: K (Lys) · Basic + · K-D -3.9K13: Q (Gln) · Polar · K-D -3.5Q14: M (Met) · Hydrophobic · K-D 1.9M15: E (Glu) · Acidic − · K-D -3.5E1516: E (Glu) · Acidic − · K-D -3.5E17: E (Glu) · Acidic − · K-D -3.5E18: A (Ala) · Hydrophobic · K-D 1.8A19: V (Val) · Hydrophobic · K-D 4.2V20: R (Arg) · Basic + · K-D -4.5R2021: L (Leu) · Hydrophobic · K-D 3.8L22: F (Phe) · Aromatic · K-D 2.8F23: I (Ile) · Hydrophobic · K-D 4.5I24: E (Glu) · Acidic − · K-D -3.5E25: W (Trp) · Aromatic · K-D -0.9W2526: L (Leu) · Hydrophobic · K-D 3.8L27: K (Lys) · Basic + · K-D -3.9K28: N (Asn) · Polar · K-D -3.5N29: G (Gly) · Special · K-D -0.4G30: G (Gly) · Special · K-D -0.4G3031: P (Pro) · Special · K-D -1.6P32: S (Ser) · Polar · K-D -0.8S33: S (Ser) · Polar · K-D -0.8S34: G (Gly) · Special · K-D -0.4G35: A (Ala) · Hydrophobic · K-D 1.8A3536: P (Pro) · Special · K-D -1.6P37: P (Pro) · Special · K-D -1.6P38: S (Ser) · Polar · K-D -0.8S39: K (Lys) · Basic + · K-D -3.9K40: K (Lys) · Basic + · K-D -3.9K4041: K (Lys) · Basic + · K-D -3.9K42: K (Lys) · Basic + · K-D -3.9K43: K (Lys) · Basic + · K-D -3.9K44: K (Lys) · Basic + · K-D -3.9K44
Hydrophobic moment0.34
Mean K-D hydropathy-1.11
Approx. net charge+3
Projection angle100° / residue
The pale sector marks the direction of the hydrophobic face inferred from μH. This is a projection assumption, not a measured fold.
HydrophobicAromaticPolarBasic +Acidic −Specialhydrophobic faceμH arrow → hydrophobic face

The projection assumes an α-helix conformation; a long μH arrow indicates an amphipathic helix, common in antimicrobial peptides.Sequence > 30 aa — only termini and every fifth position are numbered because later turns share earlier wheel angles.

Method notes

Charge model: side-chain pKa D 3.9, E 4.1, C 8.5, Y 10.1, H 6.5, K 10.8, R 12.5 with EMBOSS termini. pI is estimated by binary search on modeled net charge. Hydropathy uses Kyte-Doolittle values; hydrophobic moment follows the Eisenberg alpha-helix vector-sum convention. When the basis is a parent-residue sequence, modified chemistry is intentionally not inferred.

Computed developability descriptors

Deterministic descriptors computed from the reviewed sequence or chemical structure (RDKit), each anchored to a literature method. These are computed estimates for developability interpretation — not experimental measurements — and are validated against independent reference implementations.

Sequence-derived

Computed from the standard parent-residue sequence; protein-origin metrics defined at any length.

Aliphatic index
46.59
Instability index
53.6

Above 40 — predicted unstable in vitro.

Boman index
2.24 kcal/mol
Molar extinction coefficient (280 nm)
5,500 M⁻¹·cm⁻¹

A280 (1 g/L) ≈ 1.13

Structure-derived descriptors are not shown because this identity has no resolved chemical structure (SMILES). This is a known coverage gap for disulfide-rich and unresolved peptidoforms, not a computation error.

03

Exposure / Absorption

7 records

What evidence describes systemic exposure or absorption?

Evidence records
7
Complete canonical measurements and observations attached to this domain.
Endpoint scope
4
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
6
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
1
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeBioavailabilityAUCCmaxTmax
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
6
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
1
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
0
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Bioavailability1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

~ 32 %

Eligible when experimental context matches

FDA Clinical Review 4.4.3 pharmacokinetics manual extraction · human · plasma

Result: Approximate quantitative measurement · Molecular form: not reported · Route: subcutaneous · Source: Primary reference linked

Reference
AUC1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

444.87 ng*h/L

Eligible when experimental context matches

FDA Clinical Pharmacology Review PMR Study TDR14311 Table 7 manual extraction · human · plasma

Result: Reported point value · Molecular form: not reported · Route: subcutaneous · Dose/window: 20 mcg repeated dosing; pediatric patients with type 2 diabetes; ADA-negative P... · Time: day 42 · Source: Primary reference linked

Reference
Cmax4 records · 4 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

56.9 pg/mL

Eligible when experimental context matches

EU Clinical Trials Register PKD11475 results manual extraction · human · plasma

Result: Reported point value · Molecular form: not reported · Route: subcutaneous · Dose/window: single 10 mcg lixisenatide; adult patients with type 2 diabetes; N=10; sampling... · Time: day 1 · Source: Primary reference linked

Reference
2

34.3 pg/mL

Eligible when experimental context matches

EU Clinical Trials Register PKD11475 results manual extraction · human · plasma

Result: Reported point value · Molecular form: not reported · Route: subcutaneous · Dose/window: single 10 mcg lixisenatide; paediatric patients with type 2 diabetes; N=8; samp... · Time: day 1 · Source: Primary reference linked

Reference
3

26 pg/mL

Eligible when experimental context matches

EU Clinical Trials Register PKD11475 results manual extraction · human · plasma

Result: Reported point value · Molecular form: not reported · Route: subcutaneous · Dose/window: single 5 mcg lixisenatide; adult patients with type 2 diabetes; N=10; sampling... · Time: day 1 · Source: Primary reference linked

Reference
4

29.7 pg/mL

Eligible when experimental context matches

EU Clinical Trials Register PKD11475 results manual extraction · human · plasma

Result: Reported point value · Molecular form: not reported · Route: subcutaneous · Dose/window: single 5 mcg lixisenatide; paediatric patients with type 2 diabetes; N=8; sampl... · Time: day 1 · Source: Primary reference linked

Reference
Tmax1 record · 0 matched-context · 1 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

1-3.5 hours

3600-12600 seconds
Use only explicitly reported fields

human

Result: Interval measurement · Molecular form: not reported · Route: subcutaneous · Lixisenatide· 12.3 Pharmacokinetics · tmax median tmax range is · 12.3 Pharmacokinetics A... · Source: Primary reference linked

Reference
04

Distribution / Barrier

2 records

What is known about distribution, binding, permeability, or barrier crossing?

Evidence records
2
Complete canonical measurements and observations attached to this domain.
Endpoint scope
2
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
0
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
2
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopePlasma protein bindingVd
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
0
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
2
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
0
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Vd1 record · 0 matched-context · 1 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

~ 100 L

Use only explicitly reported fields

human

Result: Approximate quantitative measurement · Molecular form: not reported · Route: subcutaneous · Lixisenatide· 12.3 Pharmacokinetics · volume of distribution single · Distribution The ap... · Source: Primary reference linked

Reference
Plasma protein binding1 record · 0 matched-context · 1 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

55 %

Use only explicitly reported fields

plasma protein

Result: Reported point value · Molecular form: not reported · Route: SC · 55 · Lixisenatide · exact product name match · exact or normalized match · Source: Primary reference linked

Source record
Barrier and permeability assay context

PAMPA, Caco-2, MDCK/RRCK, and BBB findings are assay/model contexts under Distribution / Barrier. They should not be read as interchangeable measurements.

PAMPA
0

artificial membrane

Caco-2
0

cell monolayer

MDCK
0

cell monolayer

RRCK
0

cell monolayer

BBB
0

barrier evidence

05

Metabolic & Proteolytic Stability

1 records

How stable is the peptide in biological matrices or protease systems?

Evidence records
1
Complete canonical measurements and observations attached to this domain.
Endpoint scope
1
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
1
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
0
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeSerum/plasma stability
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
1
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
0
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
0
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Serum/plasma stability1 record · 1 matched-context · 0 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

7.1 Hours

25560 seconds
Eligible when experimental context matches

LC-MS/MS · rat · Rats blood plasma

Result: Reported point value · Molecular form: ATLPF0017463 · Dose/window: 1000 ng/mL · Rats blood plasma protease · In Vitro · Source: Primary reference linked

Reference
06

Excretion / Persistence

4 records

What evidence describes clearance or persistence?

Evidence records
4
Complete canonical measurements and observations attached to this domain.
Endpoint scope
2
Formal ADMET endpoints represented for this peptide.
Matched-context analysis
0
Quantitative results that may be analysed only with scientifically compatible records.
Reported-result review
1
Qualitative, narrative, or review-first results interpreted in their source context.
Endpoints in scopeHalf LifeClearance
Evidence interpretation

Result type, analysis use, and source-check status are kept separate so a numerical value is not mistaken for a universally comparable result.

Eligible for matched-context analysis
Quantitative results whose endpoint and context must still be matched before analysis.
0
Interpret as reported
Qualitative, narrative, or review-first findings preserved in source context.
1
Supporting context only
Reference, label, clinical, or supporting context for interpretation.
0
Review before analysis
Records whose present structure does not establish a safe analysis role.
3
Evidence by endpoint

Rows are grouped by endpoint so value, assay context, interpretation layer, and reference can be checked in place.

·
Clearance1 record · 0 matched-context · 1 as reported · 0 context only · 0 review required
#ValueAnalysis useAssay / modelResult contextReference
1

35 L/h

Use only explicitly reported fields

human

Result: Reported point value · Molecular form: not reported · Lixisenatide· 12.3 Pharmacokinetics · clearance mean apparent cl f about · After multiple... · Source: Primary reference linked

Reference
Half Life3 records · 0 matched-context · 0 as reported · 0 context only · 3 review required
#ValueAnalysis useAssay / modelResult contextReference
1

< 0.5 Hours

< 1800 seconds
Review experimental context before comparison

Not specified

Result: Upper-bound measurement · Molecular form: ATLPF0017463 · Source: Primary reference linked

Reference
2

< 0.5 Hours

< 1800 seconds
Review experimental context before comparison

Not specified

Result: Upper-bound measurement · Molecular form: ATLPF0017463 · Source: Primary reference linked

Reference
3

< 0.5 Hours

< 1800 seconds
Review experimental context before comparison

Not specified

Result: Upper-bound measurement · Molecular form: ATLPF0017463 · Source: Primary reference linked

Reference
07

Evidence landscape

14 records

Cross-domain evidence distribution and measurement-level detail; the domain modules above show evidence in context, and every row remains available for audit here.

Evidence landscape

A cross-domain view of evidence volume, scientifically permitted analysis use, and source traceability.

ADMET domain
Eligible when context matches
Interpret as reported
Supporting context only
Review before analysis
Exposure / Absorption
7 evidence records
6
1
0
0
Distribution / Barrier
2 evidence records
0
2
0
0
Metabolic & Proteolytic Stability
1 evidence record
1
0
0
0
Excretion / Persistence
4 evidence records
0
1
0
3
Toxicity / Safety
0 evidence records
0
0
0
0
Endpoint distribution

Top evidence-bearing endpoint questions.

Max Concentration
4
Half Life
3
Area Under Curve
1
Bioavailability
1
Clearance
1
Plasma Protein Binding
1
Serum Plasma Stability
1
Time To Max Concentration
1
Assay context

Broad context buckets, useful before comparing values.

In vivo / route
10
Unspecified
3
Matrix / stability
1
Traceability

Reference-link availability for measurement-level audit.

Linked reference
14
Not linked
0
All evidence index

Every evidence record remains available for audit and drilldown. Counts describe evidence volume, not confidence.

#ADMET domainEndpointReported valueResult typeAnalysis useAssay / modelConditionReference
1
Excretion / Persistence
Persistence
Half Life
< 0.5 Hours
< 1,800 seconds
Upper-bound measurementReview experimental context before comparisonNot specifiedNot specified
Reference
Primary reference linked
2
Excretion / Persistence
Persistence
Half Life
< 0.5 Hours
< 1,800 seconds
Upper-bound measurementReview experimental context before comparisonNot specifiedNot specified
Reference
Primary reference linked
3
Excretion / Persistence
Persistence
Half Life
< 0.5 Hours
< 1,800 seconds
Upper-bound measurementReview experimental context before comparisonNot specifiedNot specified
Reference
Primary reference linked
4
Metabolic & Proteolytic Stability
Stability
Serum Plasma Stability
7.1 Hours
25,560 seconds
Reported point valueEligible when experimental context matchesLC-MS/MS · rat · Rats blood plasmaDose/window: 1000 ng/mL · Protease: Rats blood plasma protease · In Vitro
Reference
Primary reference linked
5
Exposure / Absorption
Exposure
Bioavailability
~ 32 %
Approximate quantitative measurementEligible when experimental context matchesFDA Clinical Review 4.4.3 pharmacokinetics manual extraction · human · plasmaRoute: subcutaneous · Adlyxin/lixisenatide NDA 208471 clinical review · highlights of pharmacokinetics for the proposed 10 microgram starting dose and 20 microgram maintenance dose in type...
Reference
Primary reference linked
6
Exposure / Absorption
Exposure
Area Under Curve
444.87 ng*h/L
Reported point valueEligible when experimental context matchesFDA Clinical Pharmacology Review PMR Study TDR14311 Table 7 manual extraction · human · plasmaRoute: subcutaneous · Time: day 42 · Dose/window: 20 mcg repeated dosing; pediatric patients with type 2 diabetes; ADA-negative PopPK analysis; N=18 · AUC summary statistics were derived fr...
Reference
Primary reference linked
7
Exposure / Absorption
Exposure
Max Concentration
29.7 pg/mL
Reported point valueEligible when experimental context matchesEU Clinical Trials Register PKD11475 results manual extraction · human · plasmaRoute: subcutaneous · Time: day 1 · Dose/window: single 5 mcg lixisenatide; paediatric patients with type 2 diabetes; N=8; sampling through 6.5 hours post-dose · EU Clinical Trials Register...
Reference
Primary reference linked
8
Exposure / Absorption
Exposure
Max Concentration
34.3 pg/mL
Reported point valueEligible when experimental context matchesEU Clinical Trials Register PKD11475 results manual extraction · human · plasmaRoute: subcutaneous · Time: day 1 · Dose/window: single 10 mcg lixisenatide; paediatric patients with type 2 diabetes; N=8; sampling through 6.5 hours post-dose · EU Clinical Trials Registe...
Reference
Primary reference linked
9
Exposure / Absorption
Exposure
Max Concentration
26 pg/mL
Reported point valueEligible when experimental context matchesEU Clinical Trials Register PKD11475 results manual extraction · human · plasmaRoute: subcutaneous · Time: day 1 · Dose/window: single 5 mcg lixisenatide; adult patients with type 2 diabetes; N=10; sampling through 6.5 hours post-dose · EU Clinical Trials Register res...
Reference
Primary reference linked
10
Exposure / Absorption
Exposure
Max Concentration
56.9 pg/mL
Reported point valueEligible when experimental context matchesEU Clinical Trials Register PKD11475 results manual extraction · human · plasmaRoute: subcutaneous · Time: day 1 · Dose/window: single 10 mcg lixisenatide; adult patients with type 2 diabetes; N=10; sampling through 6.5 hours post-dose · EU Clinical Trials Register re...
Reference
Primary reference linked
1–10 / 14
08

Product context

1 products

Product-level route, label, and clinical context that frames peptide-level evidence. A peptide-level summary only; product pages keep the full drilldown.

·
Summary1 linked product
Linked products
1
Label context
None
Clinical trials
42
Safety label cues
None
Linked products1 shown

Lixisenatide

Peptide-product match
Unique peptide match
Route / product class
subcutaneous · Injection, solution
Clinical context
42 trial records · 7 exact intervention matches · 14 with results · latest 2026-04-08
Label safety context
No label safety cue linked
View product
09

Identity & reference map

14 sources

Reference-level support for checking reported names, sequence notation, and peptide identity agreement.

·
Summary7 reference groups
Identity type
canonical sequence
Reported notation
1
Reference groups
7
Measurements
14
ATL peptide ID
ATLPC0015930
Identity concordance
Identity concordance
Exact reported notation

Reported sequence string matches the current peptide notation.

0 / 14
Parent-residue compatible

Reported notation differs, but resolves to the same parent-residue display.

0 / 14
Different notation

Reported notation does not resolve to the current display sequence.

1 / 14
Source sequence not captured

No source-specific sequence was captured for comparison; this is not interpreted as agreement or disagreement.

13 / 14
Reported sequence notation
Different1 reference
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK-NH2
Current identity
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK
Reported names
No distinct human-readable aliases are exposed.
Reference map7 reference groups
Reference map

Grouped by reference link, with endpoint scope and reported identity kept visible.

ReferenceSupportsReported identityRecords
Reference
Open
Exposure
Max Concentration
No reported alias
4 identity
4 evidence
Reference
Open
Persistence
Half Life
No reported alias
3 identity
3 evidence
Reference
Open
DistributionExposurePersistence
Clearance, Time To Max Concentration, Volume Of Distribution
No reported alias
3 identity
3 evidence
Reference
Open
Stability
Serum Plasma Stability
No reported alias
1 identity
1 evidence
Reference
Open
Exposure
Bioavailability
No reported alias
1 identity
1 evidence
Reference
Open
Exposure
Area Under Curve
No reported alias
1 identity
1 evidence
Source record
Open
Distribution
Plasma Protein Binding
No reported alias
HGEGTFTSDLSKQMEEEAV...GPSSGAPPSKKKKKK-NH2different
1 identity
1 evidence
10

Data access & reproducibility

Stable record access, analysis-ready files, and scripted retrieval for reproducing this profile view.

·
Record scopePublic release
ATL peptide ID
ATLPC0015930
Identity type
canonical sequence
ADMET endpoints
9
Evidence records
14
Reference groups
7
Release view
Public release
Data access

Structured peptide profile

JSON

Peptide-specific profile used by this page, including identity and evidence context.

Open JSON

Peptide catalogue

TSV

Complete frozen peptide table. Filter the ATL peptide ID column locally to isolate this record.

Download catalogue

Measurement catalogue

TSV

Complete frozen measurement table. Join or filter by ATL peptide ID for peptide-level analysis.

Download measurements
Programmatic access

The request returns the same structured peptide record used by this profile. The tabular downloads are complete frozen release tables and should be filtered locally by ATL peptide ID.

Open endpoint
GET /api/v1/peptides/ATLPC0015930
open
curl -sS 'https://admetatlas.scbdd.com/api/v1/peptides/ATLPC0015930' \
  -H 'accept: application/json' \
  -H 'X-Visibility: public_release'
ADMETatlas
peptide evidence atlas

ADMETatlas is an open, curated atlas of ADMET evidence for therapeutic peptides — spanning developability, membrane permeability and blood–brain-barrier transport, immune-recognition context, and approved-product context. Every measurement stays linked to its original source, with stable identifiers and transparent curation, so results can be traced, cited, and reproduced.

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