Evidence — ADMETatlas

Evidence entries

2,539records·988linked peptides

Showing reference-linked Half-life (PK) evidence with reported value, assay context, interpretation role, and reference access kept separate.

Assay context

Evidence role

All2,539 Curated comparable2,539 Reported268

#	Endpoint	Measured entity		Assay context	Evidence role	Reference
1	Half-life (PK) Excretion / Persistence	Peptide ATLPC0005805 Specific molecular form	150 hours 540,000 seconds	HPLCCultured bovine anterior pituitary cellsbovine0.2mM	Comparable	Reference
2	Half-life (PK) Excretion / Persistence	Peptide ATLPC0010757 Specific molecular form	164.3 seconds	RadioimmunoassayMale Wistar rats plasma (Dose i/p injected)ratBlood samples collected at 5-1800 seconds after peptide injecteion1x 106 cpm	Comparable	Reference
3	Half-life (PK) Excretion / Persistence	Peptide ATLPC0012374 Specific molecular form	240 seconds	Not specified	Comparable	Reference
4	Half-life (PK) Excretion / Persistence	Peptide ATLPC0018730 Specific molecular form	6.78 minutes 406.8 seconds	Not specified	Comparable	Reference
5	Half-life (PK) Excretion / Persistence	Peptide ATLPC0027709 Specific molecular form	9.2 ± 0.5 Minutes 552 seconds	HPLCPBS solution containing all three hydrolytic enzymes (0.5 IU/mL), ACE, LAP and NEP0.1 mM	Comparable	Reference
6	Half-life (PK) Excretion / Persistence	Peptide ATLPC0032821 Specific molecular form	0.31 Hours 1,116 seconds	ELISAKunming mice plasmamouseTail vein injection	Comparable	Reference
7	Half-life (PK) Excretion / Persistence	Peptide ATLPC0008565 Specific molecular form	46.11 Hours 165,996 seconds	Sandwich ELISARhesus monkeys plasmamonkeyIV	Comparable	Reference
8	Half-life (PK) Excretion / Persistence	Peptide ATLPC0020788 Specific molecular form	2.57 ± 0.71 Hours 9,252 seconds	Rats plasmaratSC	Comparable	Reference
9	Half-life (PK) Excretion / Persistence	Peptide ATLPC0022685 Specific molecular form	2.39 minutes 143.4 seconds	Competitive RadioimmunoassayRat plasma (Intravenous)rat10 nM/ Kg	Comparable	Reference
10	Half-life (PK) Excretion / Persistence	Peptide ATLPC0009217 Specific molecular form	47 Hours 169,200 seconds	LC-MS/MSGöttingen minipigs plasmaporcineIVBlood samples were collected before RA15127343 administration (baseline) and 1–4 times per day until study end.	Comparable	Reference
11	Half-life (PK) Excretion / Persistence	Peptide ATLPC0029360 Specific molecular form	226.02 seconds	LC-MSRats plasmaratIV2 μM	Comparable	Reference
12	Half-life (PK) Excretion / Persistence	Peptide ATLPC0023486 Specific molecular form	500,400 seconds	LC-MSBeagle dogs plasmadogPO3 mg	Comparable	Reference
13	Half-life (PK) Excretion / Persistence	Measured entity Not resolved	254 Hours 914,400 seconds	LC-MSHuman plasma after SC glepaglutide 5 mg after 6 once-weekly doseshumanSC glepaglutide 10 mg after 6 once-weekly doses10 mg	Comparable	Reference
14	Half-life (PK) Excretion / Persistence	Peptide ATLPC0003166 Specific molecular form	18.5 Hours 66,600 seconds	HPLC50% w/v liver homogenateSamples (80 μL) were taken at 0, 3, 6,9, 15, 30, 45, 60, 90, 120, 180, 240, 360 and 1440 minPeptide stock solutions (120 μL) were added to pre-warmed diluted plasma (50% v/v, 1080 μL)	Comparable	Reference
15	Half-life (PK) Excretion / Persistence	Peptide ATLPC0030959 Specific molecular form	305.4 seconds	LC-MS/MSMale dogs plasma After Day 1 Repeated DosedogIV, Multiple dosesSamples Were Collected At 2,5,10,20,40 Minutes After Dosing On Days 1 Or 14	Comparable	Reference
16	Half-life (PK) Excretion / Persistence	Peptide ATLPC0009237 Specific molecular form	56.7 hours 204,120 seconds	Not specified	Comparable	Reference
17	Half-life (PK) Excretion / Persistence	Peptide ATLPC0031403 Specific molecular form	762 seconds	Radioimmunoassay and HPLC analysisIntravenous administration to human plasmahuman0, 2, 5, 7,10,15, 20, 25, 30, 45, 60, 90, 120, 150, and 180 min.75 μg	Comparable	Reference
18	Half-life (PK) Excretion / Persistence	Peptide ATLPC0009237 Specific molecular form	1.9 Hours 6,840 seconds	Not specified	Comparable	Reference
19	Half-life (PK) Excretion / Persistence	Peptide ATLPC0005195 Specific molecular form	124 Hours 446,400 seconds	LC-MSHuman plasma with Normal hepatic functionhumanSCPlasma concentrations of tirzepatide measured pre-dose, and at 8, 12, 24, 48, 72, 96, 168, and 336 hours post-dose5 mg	Comparable	Reference
20	Half-life (PK) Excretion / Persistence	Peptide ATLPC0029888 Specific molecular form	197 minutes 11,820 seconds	RP-HPLCSCLC cell line NCI-H3450-1080 minutes50μM	Comparable	Reference

1–20 / 2,539

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