Browse ADMET evidence entries by endpoint, reported value, assay context, interpretation role, and reference link. These counts indicate evidence availability, not safety, efficacy, or confidence by themselves.
Endpoints
17
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Context signals
3,678
Measurements
39,523
Interpretation: Record counts indicate evidence availability, not safety, efficacy, or confidence by themselves. Use the ADMET-domain index and role filters to narrow the evidence-entry table before comparing values.
Mild (CLcr 60-89 mL/min) or moderate (CLcr 30-59 mL/min) renal impairment has no effect on clearance of lanreotide in patients with GEP-NET based on population PK analysis which included 106 patients with mild and 59 patients with moderate renal impairment treated with SOMATULINE DEPOT.
Age has no effect on clearance of lanreotide based on population PK analysis in patients with GEP-NET which included 122 patients aged 65 to 85 years with neuroendocrine tumors.
In an elderly population, dose adjustments may be necessary due to a significant increase in the half-life (46%) and a significant decrease in the clearance (26%) of the drug.
In an elderly population, dose adjustments may be necessary due to a significant increase in the half-life (46%) and a significant decrease in the clearance (26%) of the drug.
The population pharmacokinetic analysis showed that median clearance differed slightly between the elderly group (patients ≥65, median CL=1.07 L/h) and the non-elderly group (patients <65, median CL=1.22 L/h) and the range of clearance was similar.
Total plasma clearance (CL T ), elimination half-life (t 1/2 ), and volume of distribution at steady-state (V ss ) in patients with cSSSI were similar to those in patients with S. aureus bacteremia.
the mean CL T was 9%, 22%, and 46% lower among subjects and patients with mild (CL CR 50–80 mL/min), moderate (CL CR 30–<50 mL/min), and severe (CL CR <30 mL/min) renal impairment, respectively, than in those with normal renal function (CL CR >80 mL/min).
the mean total clearance of daptomycin was approximately 35% lower and the mean AUC 0–∞ was approximately 58% higher in elderly subjects than in healthy young adult subjects.
the total plasma clearance of daptomycin normalized to total body weight was approximately 15% lower in moderately obese subjects and 23% lower in extremely obese subjects than in nonobese controls.
In a study performed in 4 subjects with end-stage renal disease (creatinine clearance < 5 mL/min), an intravenous infusion of 3.5 mg/kg of cyclosporine over 4 hours administered at the end of a hemodialysis session resulted in a mean volume of distribution (Vdss) of 3.49 L/kg and systemic clearance (CL) of 0.369 L/hr/kg.
This systemic CL (0.369 L/hr/kg) was approximately two thirds of the mean systemic CL (0.56 L/hr/kg) of cyclosporine in historical control subjects with normal renal function.
