ADMETatlas — Peptide ADMET Evidence Atlas

All evidence

37,547records·25,806peptides

Showing reference-linked evidence across every ADMET endpoint. Pick a domain or endpoint in the index to narrow it.

Assay context

Evidence role

All37,547 Curated comparable37,547 Reported1,976

#	Endpoint	Peptide	Reported value	Assay context	Evidence role	Reference
1	AUC Exposure / Absorption	ATLPC0011879	2.762 ng*h/mL	Canadian Product Monograph Table 6 pharmacokinetics manual extractionplasmahumanintravenous100 mcg IV carbetocin; N=19; AUC0-inf	Comparable	Open
2	AUC Exposure / Absorption	ATLPC0011879	2.147 ng*h/mL	Canadian Product Monograph Table 6 pharmacokinetics manual extractionplasmahumanintramuscular100 mcg IM carbetocin; N=20; AUC0-inf	Comparable	Open
3	AUC Exposure / Absorption	ATLPC0021413	4.1 ng*h/mL	Canadian Product Monograph Table single-dose pharmacokinetics manual extractionserumhumanintranasalsingle dose400 mcg intranasal nafarelin; AUC0-inf	Comparable	Open
4	AUC Exposure / Absorption	ATLPC0021413	59.8 ng*h/mL	Canadian Product Monograph Table single-dose pharmacokinetics manual extractionserumhumansubcutaneoussingle dose400 mcg subcutaneous nafarelin; AUC0-inf	Comparable	Open
5	AUC Exposure / Absorption	ATLPC0021413	7.9 ng*h/mL	Canadian Product Monograph Table single-dose pharmacokinetics manual extractionserumhumanintravenoussingle dose25 mcg intravenous nafarelin; AUC0-inf	Comparable	Open
6	AUC Exposure / Absorption	ATLPC0015930	444.87 ng*h/L	FDA Clinical Pharmacology Review PMR Study TDR14311 Table 7 manual extractionplasmahumansubcutaneousday 4220 mcg repeated dosing; pediatric patients with type 2 diabetes; ADA-negative PopPK analysis; N=18	Comparable	Open
7	AUC Exposure / Absorption	ATLPC0009237	291.88 ng*h/mL	AUC in cannulated Sprague-Dawley rat at 10 nmol, sc after 4 hrs by EIAratsc	Comparable	Open
8	AUC Exposure / Absorption	ATLPC0009237	3,153.07 ng*h/mL	AUC (0 to infinity) in Sprague-Dawley rat at 15 nmol/kg, sc by LC-MS/MS analysisratsc	Comparable	Open
9	AUC Exposure / Absorption	ATLPC0024280	18,073.59 ng*h/mL	AUC (0 to infinity) in Sprague-Dawley rat at 15 nmol/kg, sc by LC-MS/MS analysisratsc	Comparable	Open
10	AUC Exposure / Absorption	ATLPC0006962	26,900 ng*h/mL	AUC (0 to t) in rat at 4 mg/kg, iv administered as single doserativ	Comparable	Open
11	AUC Exposure / Absorption	ATLPC0018293	138 ng*h/mL	AUC in overnight fasted C57BL/6N mouse at 1 mg/kg, ipmouseip	Comparable	Open
12	AUC Exposure / Absorption	ATLPC0029647	7.65 ng*h/mL	Area under the curve administered intravenously in rats.rativ	Comparable	Open
13	AUC Exposure / Absorption	ATLPC0029647	0.867 ng*h/mL	Area under the curve administered intraintestinal in rats.rat	Comparable	Open
14	AUC Exposure / Absorption	ATLPC0008117	238 ng*h/mL	AUC last in human patient with relapsed solid tumor at 20 mg/m'2, iv administered on days 1, 2, 8, 9, 15 and 16 of 28-day cycle over 2 to 10 mins measured on day 1 of cycle 1 by LC-MS/MS analysishumaniv	Comparable	Open
15	AUC Exposure / Absorption	ATLPC0008117	301 ng*h/mL	AUC last in human patient with relapsed solid tumor at 20 mg/m'2, iv administered on days 1, 2, 8, 9, 15 and 16 of 28-day cycle over 2 to 10 mins measured on day 16 of cycle 1 by LC-MS/MS analysishumaniv	Comparable	Open
16	AUC Exposure / Absorption	ATLPC0008117	238 ng*h/mL	AUC infinity in human patient with relapsed solid tumor at 20 mg/m'2, iv administered over 2 to 10 mins on days 1, 2, 8, 9, 15 and 16 of 28-day cycle measured on day 1 of cycle 1 by LC-MS/MS analysishumaniv	Comparable	Open
17	AUC Exposure / Absorption	ATLPC0008117	301 ng*h/mL	AUC infinity in human patient with relapsed solid tumor at 20 mg/m'2, iv administered on days 1, 2, 8, 9, 15 and 16 of 28-day cycle over 2 to 10 mins measured on day 16 of cycle 1 by LC-MS/MS analysishumaniv	Comparable	Open
18	AUC Exposure / Absorption	ATLPC0008117	357.08 ng*h/mL	AUC (0 to infinity) in ICR mouse at 5 mg/kg, iv by LC-MS/MS analysismouseiv	Comparable	Open
19	AUC Exposure / Absorption	ATLPC0008117	355.18 ng*h/mL	AUC (0 to t) in ICR mouse at 5 mg/kg, iv by LC-MS/MS analysismouseiv	Comparable	Open
20	AUC Exposure / Absorption	ATLPC0008117	343 ng*h/mL	AUC(0 to t) in Sprague-Dawley rat at 4 mg/kg, iv measured up to 48 hrs by LC-MS/MS analysisrativ	Comparable	Open

1–20 / 37,547

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