ADMETatlas — Peptide ADMET Evidence Atlas

Evidence entries

27records·47peptides

Showing reference-linked Plasma protein binding evidence with reported value, assay context, interpretation role, and reference access kept separate.

Assay context

Evidence role

All27 Curated comparable98 Reported27

#	Endpoint	Peptide		Assay context	Evidence role	Reference
1	Plasma protein binding Distribution / Barrier	ATLPC0004440	Observation plasma protein binding not determined due to hydrolysis of vosoritide in human plasma	FDA Integrated Review Table 5 manual extractionplasmahuman	Reported	Open
2	Plasma protein binding Distribution / Barrier	ATLPC0024280	> 98 %	PepTherDia curated product PK fieldplasma proteinSC	Reported	Open
3	Plasma protein binding Distribution / Barrier	ATLPC0023266	Observation Pramlintide does not extensively bind to blood cells or albumin (approximately 40% of the drug is unbound in plasma).	PepTherDia curated product PK fieldplasma proteinSC	Reported	Open
4	Plasma protein binding Distribution / Barrier	ATLPC0009237	Observation Not determined	PepTherDia curated product PK fieldplasma proteinSC	Reported	Open
5	Plasma protein binding Distribution / Barrier	ATLPC0019952	Observation Plecanatide exhibits little to no binding to human serum albumin or human α-1-acid glycoprotein.	PepTherDia curated product PK fieldplasma proteinORAL	Reported	Open
6	Plasma protein binding Distribution / Barrier	ATLPC0013872	> 90 %	PepTherDia curated product PK fieldplasma proteinIV	Reported	Open
7	Plasma protein binding Distribution / Barrier	ATLPC0002714	Observation No binding	PepTherDia curated product PK fieldplasma proteinIV, IM, SC, NASAL	Reported	Open
8	Plasma protein binding Distribution / Barrier	ATLPC0020556	Observation About 50% of the administered dose is taken up by erythrocytes while about 34% is bound to lipoproteins. Prescribing information for Sandimmune states that 90% is mainly bound to lipoproteins.	PepTherDia curated product PK fieldplasma proteinTOPICAL, OPHTALMIC, IV, ORAL	Reported	Open
9	Plasma protein binding Distribution / Barrier	ATLPC0002483	> 80 %	Plasma protein binding in ratplasmarat	Reported	Open
10	Plasma protein binding Distribution / Barrier	ATLPC0020556	> 99.6 %	Plasma protein binding in human after 30 min by ultrafiltrationplasmahuman	Reported	Open
11	Plasma protein binding Distribution / Barrier	ATLPC0020556	> 99 %	Percentage bound in human plasma at 1 uM after 5 hrs by dialysis chamber methodplasmahuman	Reported	Open
12	Plasma protein binding Distribution / Barrier	ATLPC0015133	Observation human plasma protein binding statement: dulaglutide shown not to bind to human plasma proteins; no numeric percent reported	Manual extraction from open-access GLP-1RA potency/PK article; human plasma protein-binding statementplasmahuman	Reported	Open
13	Plasma protein binding Distribution / Barrier	ATLPC0019952	Observation Plecanatide exhibited little to no binding to human serum albumin or human α-1-acid glycoprotein.	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open
14	Plasma protein binding Distribution / Barrier	ATLPC0024280	> 98 %	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open
15	Plasma protein binding Distribution / Barrier	ATLPC0024280	> 98 %	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open
16	Plasma protein binding Distribution / Barrier	ATLPC0011948	> 99 %	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open
17	Plasma protein binding Distribution / Barrier	ATLPC0011948	> 99 %	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open
18	Plasma protein binding Distribution / Barrier	ATLPC0011948	> 99 %	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open
19	Plasma protein binding Distribution / Barrier	ATLPC0018357	Observation Distribution Vasopressin does not appear to bind plasma protein.	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open
20	Plasma protein binding Distribution / Barrier	ATLPC0029896	> 99 %	DailyMed SPL 12.3 Pharmacokinetics label extractionplasmahuman	Reported	Open

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Measurements

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Evidence entries