Evidence — ADMETatlas

Evidence entries

45records·52linked peptides

Showing reference-linked Plasma protein binding evidence with reported value, assay context, interpretation role, and reference access kept separate.

Assay context

Evidence role

All45 Curated comparable111 Reported45

#	Endpoint	Measured entity		Assay context	Evidence role	Reference
1	Plasma protein binding Distribution / Barrier	Peptide ATLPC0004440 Peptide backbone	Observation plasma protein binding not determined due to hydrolysis of vosoritide in human plasma	FDA Integrated Review Table 5 manual extractionplasmahuman	Reported	Reference
2	Plasma protein binding Distribution / Barrier	Peptide ATLPC0024280 Peptide backbone	numeric	plasma proteinSC	Reported	Source record
3	Plasma protein binding Distribution / Barrier	Peptide ATLPC0023266 Peptide backbone	Observation Pramlintide does not extensively bind to blood cells or albumin (approximately 40% of the drug is unbound in plasma).	plasma proteinSC	Reported	Source record
4	Plasma protein binding Distribution / Barrier	Peptide ATLPC0009237 Peptide backbone	Observation Not determined	plasma proteinSC	Reported	Source record
5	Plasma protein binding Distribution / Barrier	Peptide ATLPC0019952 Peptide backbone	Observation Plecanatide exhibits little to no binding to human serum albumin or human α-1-acid glycoprotein.	plasma proteinORAL	Reported	Source record
6	Plasma protein binding Distribution / Barrier	Peptide ATLPC0013872 Peptide backbone	numeric	plasma proteinIV	Reported	Source record
7	Plasma protein binding Distribution / Barrier	Product ATLPD0000051 Whole product	Observation No binding	plasma proteinIV, IM, SC, NASAL	Reported	Source record
8	Plasma protein binding Distribution / Barrier	Peptide ATLPC0020556 Peptide backbone	Observation About 50% of the administered dose is taken up by erythrocytes while about 34% is bound to lipoproteins. Prescribing information for Sandimmune states that 90% is mainly bound to lipoproteins.	plasma proteinTOPICAL, OPHTALMIC, IV, ORAL	Reported	Source record
9	Plasma protein binding Distribution / Barrier	Peptide ATLPC0002483 Peptide backbone	numeric	Plasma protein binding in ratplasmarat	Reported	Reference
10	Plasma protein binding Distribution / Barrier	Peptide ATLPC0020556 Peptide backbone	numeric	Plasma protein binding in human after 30 min by ultrafiltrationplasmahuman	Reported	Reference
11	Plasma protein binding Distribution / Barrier	Peptide ATLPC0020556 Peptide backbone	numeric	Percentage bound in human plasma at 1 uM after 5 hrs by dialysis chamber methodplasmahuman	Reported	Reference
12	Plasma protein binding Distribution / Barrier	Product ATLPD0000022 Whole product	~= 50 %	Manual extraction from open-access clinical review; review-supported human plasma protein-binding statementplasmahuman	Reported	Reference
13	Plasma protein binding Distribution / Barrier	Peptide ATLPC0015133 Peptide backbone	Observation human plasma protein binding statement: dulaglutide shown not to bind to human plasma proteins; no numeric percent reported	Manual extraction from open-access GLP-1RA potency/PK article; human plasma protein-binding statementplasmahuman	Reported	Reference
14	Plasma protein binding Distribution / Barrier	Peptide ATLPC0019952 Specific molecular form	Observation Plecanatide exhibited little to no binding to human serum albumin or human α-1-acid glycoprotein.	plasmahuman	Reported	Reference
15	Plasma protein binding Distribution / Barrier	Peptide ATLPC0024280 Specific molecular form	numeric	plasmahuman	Reported	Reference
16	Plasma protein binding Distribution / Barrier	Peptide ATLPC0024280 Specific molecular form	numeric	plasmahuman	Reported	Reference
17	Plasma protein binding Distribution / Barrier	Peptide ATLPC0011948 Specific molecular form	numeric	plasmahuman	Reported	Reference
18	Plasma protein binding Distribution / Barrier	Peptide ATLPC0011948 Specific molecular form	numeric	plasmahuman	Reported	Reference
19	Plasma protein binding Distribution / Barrier	Peptide ATLPC0011948 Specific molecular form	numeric	plasmahuman	Reported	Reference
20	Plasma protein binding Distribution / Barrier	Peptide ATLPC0018357 Peptide backbone	Observation Distribution Vasopressin does not appear to bind plasma protein.	plasmahuman	Reported	Reference

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